A5015920372- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Mycology
- Cystic Fibrosis Research Advances
- Tracheal and airway disorders
- Pediatric health and respiratory diseases
- Quinazolinone synthesis and applications
- Microwave-Assisted Synthesis and Applications
- Gut microbiota and health
- Neonatal Respiratory Health Research
- Helicobacter pylori-related gastroenterology studies
- Dysphagia Assessment and Management
- Actinomycetales infections and treatment
- Respiratory and Cough-Related Research
- Burn Injury Management and Outcomes
- Streptococcal Infections and Treatments
- Respiratory viral infections research
- Agriculture, Soil, Plant Science
- Enterobacteriaceae and Cronobacter Research
- Cytomegalovirus and herpesvirus research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Posttraumatic Stress Disorder Research
- Aluminum Alloy Microstructure Properties
- Fungal Infections and Studies
- Infective Endocarditis Diagnosis and Management
Greenslopes Private Hospital
2016-2025
Prince Charles Hospital
2009-2025
The University of Queensland
2016-2025
Queensland Health
2014-2025
Gallipoli Medical Research Foundation
2015-2024
Brighton and Sussex Medical School
2024
Newcastle upon Tyne Hospital
2023
Lung Foundation Australia
2022
Princess Alexandra Hospital
2018-2021
Metro South Health
2019-2021
A significant knowledge gap exists concerning the geographical distribution of nontuberculous mycobacteria (NTM) isolation worldwide. To provide a snapshot NTM species distribution, global partners in NTM-Network European Trials Group (NET) framework ( www.ntm-net.org ), branch Tuberculosis Network (TB-NET), provided identification results total number patients 2008 whom were isolated from pulmonary samples. From these data, we visualised relative different found per continent and country....
Global spread of aggressive mycobacteria Many mycobacteria, in addition to those causing leprosy and tuberculosis, are capable infecting humans. Some can be particularly dangerous patients suffering from immunosuppression or chronic disease, such as cystic fibrosis (CF). Bryant et al. observed clusters near-identical isolates drug-resistant Mycobacterium abscessus reporting CF clinics. The similarity the suggests transmission between patients, rather than environmental acquisition. Although...
Nontuberculous mycobacteria (NTM) disease is a notifiable condition in Queensland, Australia. Mycobacterial isolates that require species identification are forwarded to the Queensland Reference Laboratory, providing central opportunity capture statewide data on epidemiology of NTM disease. We compared obtained 1999 and 2005 used from notification scheme report clinical relevance these isolates. The incidence notified cases clinically significant pulmonary rose 2.2 (1999) 3.2 (2005) per...
Rationale: Improved therapeutic options are needed for patients with treatment-refractory nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex (MAC). Objectives: To evaluate the efficacy and safety of daily amikacin liposome inhalation suspension (ALIS) added to standard guideline-based therapy (GBT) in refractory MAC disease. Methods: Adults amikacin-susceptible MAC-positive sputum cultures despite at least 6 months stable GBT were randomly assigned (2:1) receive...
It has been postulated that susceptible individuals may acquire infection with nontuberculous mycobacteria (NTM) from water and aerosol exposure. This study examined household shower aerosols of patients NTM pulmonary disease. The isolated clinical samples 20 included M. avium (5 patients), intracellulare (12 abscessus (7 gordonae (1 patient), lentiflavum fortuitum peregrinum chelonae triplex kansasii patient). One-liter swabs were collected all taps, swimming pools or rainwater tanks....
Nontuberculous mycobacteria (NTM) are normal inhabitants of a variety environmental reservoirs including natural and municipal water. The aim this study was to document the species NTM in potable water Brisbane, QLD, with specific interest main pathogens responsible for disease region explore factors associated isolation NTM. One-litre samples were collected from 189 routine collection sites summer 195 winter. Samples split, half decontaminated CPC 0.005%, then concentrated by filtration...
Mycobacterium abscessus is a rapidly growing mycobacterium responsible for progressive pulmonary disease, soft tissue and wound infections. The incidence of disease due to M. has been increasing in Queensland. In study Brisbane drinking water, was isolated from ten different locations.The aim this compare genotypically the isolates obtained water those human clinical specimens.Between 2007 2009, eleven confirmed as were recovered potable one strain rainwater tank another swimming pool two...
Abstract Mycobacterium abscessus , a multidrug-resistant nontuberculous mycobacterium, has emerged as major pathogen affecting people with cystic fibrosis (CF). Although originally thought to be acquired independently from the environment, most individuals are infected one of several dominant circulating clones (DCCs), indicating presence global transmission networks M. . How and when these spread globally is unclear. Here, we use evolutionary analyses isolates both without CF reconstruct...
To determine whether the prevalence of physical comorbidities in Australian Vietnam War veterans with post-traumatic stress disorder (PTSD) is higher than trauma-exposed without PTSD.Cross-sectional analysis health status (based on self-reported and objective clinical assessments) 298 enrolled by Gallipoli Medical Research Institute (Brisbane) during February 2014 - July 2015, whom 108 were confirmed as having had PTSD 106 served control participants.Main outcomes measures: Diagnostic...
In November 2002, the first of three outbreaks Salmonella Montevideo infection in Australia and New Zealand was identified South Wales, Australia. Affected persons were interviewed, epidemiologically linked retail outlets inspected. Imported tahini rapidly as source infection. The contaminated recalled international alerts posted. A second outbreak June–July 2003 another August 2003. a total 68 S. infections, 66 cases contacted. Fifty-four (82%) reported consumption sesame seed-based foods....
The epidemiology of infections with nontuberculous mycobacteria (NTM) has been changing and the incidence increasing in some settings. main route transmission to humans is considered be from environment. We aimed describe spatial clusters cases NTM identify associated climatic, environmental socio-economic variables. data were obtained Queensland Mycobacterial Reference Laboratory for period 2001–2011. A Bayesian conditional autoregressive model was constructed at postcode level, covariates...
Recent demonstrations that long-term macrolide therapy can prevent exacerbations in chronic airways diseases have led to a dramatic increase their use. However, little is known about the wider, potentially adverse impacts of these treatments. Substantial disruption upper airway commensal microbiota might reduce its contribution host defense and local immune regulation, while increases resistance carriage would represent serious public health concern. Using samples from randomized controlled...
Rationale: Patients with refractory Mycobacterium avium complex (MAC) lung disease have limited treatment options. In the CONVERT study, amikacin liposome inhalation suspension (ALIS) added to guideline-based therapy (GBT) increased culture conversion rates versus GBT alone by Month 6. Limited data are available regarding >6-month in a population.Objectives: Evaluate 12-month safety, tolerability, and efficacy of ALIS+GBT.Methods: Adults MAC not achieving 6 could enroll this open-label...
BackgroundIn the CONVERT study, treatment with amikacin liposome inhalation suspension (ALIS) added to guideline-based therapy (GBT) met primary end point of increased culture conversion by month 6 in patients treatment-refractory Mycobacterium avium complex lung disease (ALIS plus GBT, 29% [65/224] vs GBT alone, 8.9% [10/112]; P < .0001).Research QuestionIn who achieved was sustained (negative sputum results for 12 months treatment) and durable 3 after were there any additional safety...