A5087676335- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Cystic Fibrosis Research Advances
- HIV-related health complications and treatments
- Immunodeficiency and Autoimmune Disorders
- HIV, Drug Use, Sexual Risk
- Mycobacterium research and diagnosis
- Syphilis Diagnosis and Treatment
- Immune Cell Function and Interaction
- Adolescent Sexual and Reproductive Health
- Pneumocystis jirovecii pneumonia detection and treatment
- Reproductive tract infections research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Tracheal and airway disorders
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Mycology
- Neonatal Respiratory Health Research
- Cytomegalovirus and herpesvirus research
- Cervical Cancer and HPV Research
- Viral-associated cancers and disorders
- Long-Term Effects of COVID-19
- Child Nutrition and Feeding Issues
- Hepatitis Viruses Studies and Epidemiology
Rigshospitalet
2016-2025
Copenhagen University Hospital
2016-2025
University of Copenhagen
2006-2023
Aarhus University
2021
Capital Region of Denmark
2019
Institute of Clinical Research
2018
Odense University Hospital
1997-2016
Aalborg University Hospital
2016
Aarhus University Hospital
2016
Charles University
2015
Global spread of aggressive mycobacteria Many mycobacteria, in addition to those causing leprosy and tuberculosis, are capable infecting humans. Some can be particularly dangerous patients suffering from immunosuppression or chronic disease, such as cystic fibrosis (CF). Bryant et al. observed clusters near-identical isolates drug-resistant Mycobacterium abscessus reporting CF clinics. The similarity the suggests transmission between patients, rather than environmental acquisition. Although...
The inattentive and/or hyperactive—impulsive behaviors that typify attention-deficit/hyperactivity disorder (ADHD) have been associated with increased stress in parents of children who are so diagnosed and known to adversely affect the quality parent—child interactions. Far less is known, however, about effects ADHD on interactions between students their teachers levels teacher stress. Using Index Teaching Stress, an instrument assessing a teacher's subjective level frustration response...
Objective: Recently, it has been shown that a homozygous 32 base-pair deletion in the gene encoding CKR-5, major coreceptor for HIV-1, leads to resistance infection with HIV-1. We have investigated whether HIV-seropositive individuals who were heterozygous CKR-5 had different course of disease. Design: Thirty-five high-risk HIV-seronegative and 99 Danish homosexual men followed from 1985 1996 37 blood donors analysed their genotype by polymerase chain reaction. Results: Two (6%) 35 subjects...
To better understand the relative effects of infection with nontuberculous mycobacteria and Gram negative bacteria on lung function decline in cystic fibrosis, we assessed impact each a Danish setting.Longitudinal registry study 432 patients fibrosis contributing 53,771 measures between 1974 2014. We used mixed model longitudinally structured correlation, while adjusting for clinically important covariates.Infections significant rate %FEV1 were Mycobacterium abscessus complex -2.22% points...
Nontuberculous mycobacteria (NTM) are an emerging threat to cystic fibrosis (CF) patients but their epidemiology is not well described.In this retrospective observational study we identified all Scandinavian CF with a positive NTM culture from airway secretions 2000 the end of 2012 and used national databases describe microbiological clinical characteristics.During 13-year period 157 (11%) were for at least once. Mycobacterium abscessus complex (MABSC) (45%) avium (MAC) (32%) predominant...
Prolonged neuropsychiatric and cognitive symptoms are increasingly reported in patients after COVID-19, but studies with well-matched controls lacking.To investigate impairment, diagnoses, survivors of COVID-19 compared hospitalized for non-COVID-19 illness.This prospective case-control study from a tertiary referral hospital Copenhagen, Denmark, conducted between July 2020 2021, followed up control illness, matched age, sex, intensive care unit (ICU) status 6 months symptom...
There is considerable debate about which empirical research methods best advance clinical outcomes in psychotherapy. The prevailing tendency has been to test treatment packages using randomized, controlled trials. Recently, focus shifted considering how studying the process of change naturalistic treatments can be a useful complement Clinicians self-identifying as psychodynamic treated 17 panic disorder patients psychotherapy for an average 21 sessions. Patients achieved statistically...
Objective The study investigated markers of inflammation and endothelial activation in HIV infected patients after 12 years successful combination antiretroviral treatment (cART). Methods Inflammation were assessed by measuring levels immunoglobulins, β2-microglobulin, interleukin (IL) 8, tumor necrosis factor α (TNFα), vascular cell adhesion molecule-1 (sVCAM-1), intercellular (sICAM-1), sE-Selectin, sP-Selectin. Results had higher IL-8, TNFα, sICAM-1 than uninfected controls, lacked...
Cystic fibrosis (CF) is a life shortening disease, however prognosis has improved and the adult population growing. Most adults with cystic live independent lives balance demands of work family significant treatment burden. The aim this study was to examine relationships among adherence, symptoms depression health-related quality (HRQoL) in young CF.We administered three standardized questionnaires 67 patients CF aged 18-30 years; Morisky Medication Adherence Scale, Major Depression...
Cystic fibrosis (CF) care in Denmark has been characterized by close monitoring and pre-emptive treatment of lung disease other CF-related complications. Continuous evaluation through data collection commitment to clinical research incrementally improved outcomes. This approach line with best practices set forth European Standards Care but also gone beyond Society standards particularly pertaining early high-dose combination antimicrobial therapy. Despite a high prevalence severe CF...
Objective: To investigate the longitudinal changes in serum HIV RNA, and to clarify whether viral load early infection has a predictive value for clinical outcome; also, correlate phenotype at seroconversion CD4 cell counts with burden. Design: Twenty seroconverters isolates available had RNA quantified by polymerase chain reaction (PCR) thereafter every 6 months. Mean follow-up time was 65 Patients were classified according seroconversion, AIDS progression, within first year (less or more...
In this study, we identified all adults living in Denmark diagnosed with common variable immunodeficiency (CVID) and characterized them according to clinical presentation EUROclass classification. Using a retrospective, cross-sectional design, possible CVID patients were the Danish National Patient Register Centers treating primary immunodeficiencies. The diagnosis was verified by review of medical records. One-hundred-seventy-nine identified. This corresponds prevalence 1:26,000. median age...
Objective: It has been suggested that the plasma HIV RNA level is a better predictor of AIDS and death than CD4 lymphocyte count. We assessed whether prognostic value virus levels was different according to Design: Prospective cohort study HIV-infected patients followed for median 2.91 years (range, 0.02–4.54). Setting: Department Infectious Diseases at Rigshospitalet, Copenhagen, Denmark. Participants: A group 255 individuals with an initial measurement count RNA. Main outcome measure:...
Objectives: To compare the efficacy and safety of indinavir 800mg three times a day, ritonavir 600mg twice combination 400mg day saquinavir when administered with two nucleoside analogues. Design: A randomized, open-labelled, controlled trial. Two hundred eighty-four patients started randomized treatment. The primary end-point was proportion HIV RNA 200 copies/ml or less (Roche Amplicor) 20 ultradirect assay) at 6 months. Analysis performed as intent-to-treat, missing values were accounted...
Background: Highly active antiretroviral therapy containing three nucleoside reverse transcriptase inhibitors has been somewhat successful, but the clinical efficacy is unclear. Methods: Randomized, controlled, open-label trial of 180 drug-naive HIV-infected patients allocated to a regimen abacavir, stavudine and didanosine (A/S/D, n = 60), ritonavir saquinavir (R/S 400/400 mg twice daily; 60) or nelfinavir nevirapine (N/N 1250/200 60); latter two in combination with lamivudine zidovudine....
Background: A subgroup of HIV-1-infected individuals, elite controllers, have spontaneous viral control and offer an exceptional opportunity to study virological immunolocigal factors possible involvement in HIV-1 infection. Methods: The frequencies Tregs TH17 cells was evaluated correlated markers disease progression peripheral blood mononuclear from 3 different groups individuals infected with HIV-1: treatment-naive viremic on successful highly active antiretroviral therapy, controllers....
We have designed a therapeutic HIV-1 vaccine concept based on peptides together with the adjuvant CAF01. Peptides represented 15 HLA-supertype-restricted subdominant and conserved CD8 T cell epitopes three CD4 T-helper epitopes. In this phase I clinical trial, safety immunogenicity were assessed in untreated HIV-1-infected individuals Guinea-Bissau, West Africa. Twenty-three randomized to receive placebo (n=5) or (n=18). Safety was appraised by follow-up combined monitoring of biochemistry,...
HIV infection is associated with increased risk of coronary heart disease beyond that explained by traditional factors, and altered gut microbiota has been proposed as a potential trigger. Trimethylamine-N-oxide (TMAO) proatherogenic substance formed in the liver from trimethylamine, exclusively generated dietary phosphatidylcholine. We aimed to investigate whether TMAO subclinical clinical infection.Two previously described cohorts were examined follows: (1) cross-sectional cohort...
Objective: To investigate physical, psychosocial and sexual health outcomes in ≥50 years-old people with without HIV. Design: Cross-sectional study Denmark comparing by HIV status. Methods: Data were drawn from the SHARE study, a nationwide survey conducted between 2021 2022, examining psychosocial, reproductive (PWH), compared to data (PWOH) nationally representative Project SEXUS cohort study. Health assessed using validated patient-reported outcome measures, sex-stratified logistic...
Background. Immunological and virological consequences of low-level viremia in human immunodeficiency virus (HIV) type 1-infected patients receiving highly active antiretroviral therapy (HAART) remain to be determined.
Studies have suggested that HIV-1 may develop thymidine analogue mutations (TAMs) by one of two distinct pathways - the TAM1 pathway (including 41L, 210W and 215Y) or TAM2 67N, 70R 219E/Q) under pressure a not fully suppressive thymidine-analogue-containing regimen.Frozen plasma samples stored in EuroSIDA repository were selected sent to central laboratories for genotypic analysis. We considered 733 patients with at least test showing > =1 TAMs (the first these tests chronological order was...