Adriana Durán
A5081489843- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- HIV/AIDS oral health manifestations
- HIV-related health complications and treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 detection and testing
- Sex work and related issues
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Health and Lifestyle Studies
- Biochemical Analysis and Sensing Techniques
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Muscle metabolism and nutrition
- Pleural and Pulmonary Diseases
- Pericarditis and Cardiac Tamponade
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Pediatric health and respiratory diseases
- Sports and Physical Education Studies
- Ethics and bioethics in healthcare
- Medication Adherence and Compliance
- Adolescent Sexual and Reproductive Health
Ministerio de Salud
2013-2023
Universidade Federal do ABC
2021-2022
Faculdade de Medicina do ABC
2021
University of Zulia
2017
Hospital Ramos Mejía
1998-2014
Medica (United States)
2014
This trial assessed the rate of virological failure at 48 weeks in adult human immunodeficiency virus (HIV) type 1-infected patients assigned indinavir/ritonavir (Idv/Rtv; 800/100 mg 2 times daily) or saquinavir/ritonavir (Sqv/Rtv; 1000/100 an open-label, randomized (1:1), multicenter, phase 4 design. Three hundred six began treatment. At weeks, was seen 43 (27%) 158 and 37 (25%) 148 Idv/Rtv Sqv/Rtv arms, respectively. The time to did not differ between study arms (P=.76). When switching...
To assess the rate of protocol-defined treatment failure and safety lopinavir/ritonavir (LPV/r) saquinavir/ritonavir (SAQ/r).Open-label, prospective, randomized (1:1), international multi-centre trial.Adult HIV-1-infected patients were assigned LPV/r 400/100 mg twice daily or SAQ/r 1000/100 with two more nucleoside reverse transcriptase inhibitors (NRTIs)/non-NRTIs. All patients, whether on off treatment, followed for 48 weeks.Of 339 324 initiated (intention-to-treat/exposed [ITT/e]...
Studies have suggested that HIV-1 may develop thymidine analogue mutations (TAMs) by one of two distinct pathways - the TAM1 pathway (including 41L, 210W and 215Y) or TAM2 67N, 70R 219E/Q) under pressure a not fully suppressive thymidine-analogue-containing regimen.Frozen plasma samples stored in EuroSIDA repository were selected sent to central laboratories for genotypic analysis. We considered 733 patients with at least test showing > =1 TAMs (the first these tests chronological order was...
To compare virological outcome and genotypic resistance profiles in HIV-1-infected patients starting non-nucleoside reverse transcriptase inhibitor (NNRTI)-containing regimens.NNRTI-naive were included who started treatment with nevirapine (NVP) or efavirenz (EFV) test results available at time of initiation (baseline). Virological failure was defined as two consecutive values > 500 copies/ml after the regimen. Cox models used to investigate (the first values).A total 759 (13%...
Objective: To quantify primary resistance mutations (PRMs) among HIV-1-infected women receiving antiretroviral therapy (ART) for prevention of mother-to-child transmission (MTCT). Methods: Peripheral blood mononuclear cell samples from enrolled in a prospective cohort study Argentina, the Bahamas, Brazil, and Mexico (NISDI Perinatal Study) were assayed PRMs. Eligible those by March 2005 diagnosed with HIV-1 infection during current pregnancy, who received ART MTCT prophylaxis followed 6–12...
Access to highly active antiretroviral therapy (HAART) is expanding in Latin America. Many patients require second and third line due toxicity, tolerability, failure, or a combination of factors. The need for HAART, essential program planning, not known.Antiretroviral-naïve ≥18 years who started first HAART after January 1, 2000 Caribbean, Central South America Network (CCASAnet) sites Argentina, Brazil, Honduras, Mexico, Peru were included. Clinical trials participants excluded. Third was...
Background Liver damage associated with hepatitis C (HCV) may influence the likelihood of experiencing discontinuation due to toxicities or patient/physician choice (TOXPC) in patients taking combination antiretroviral therapy (cART). Little information address this concern is available from clinical trials as HCV are often excluded. Aims To compare incidence rates TOXPC specific antiretrovial drugs without HCV. Patients/methods A total 4929 EuroSIDA under follow-up January 1999 on a...
Worldwide, the distribution of HIV-1 subtypes and intersubtype recombinants is not homogeneous. In Latin America Caribbean, subtype B predominates. However, in south Brazil countries Southern cone (Argentina, Chile, Paraguay, Uruguay) there a different viral recombinants. The aim this work was to analyze diversity cohort pregnant women (with primarily heterosexual acquisition infection) who were diagnosed with infection during their current pregnancy received ARVs for perinatal transmission...
Objective To assess whether differences in safety profiles between nevirapine (NVP) and efavirenz (EFV), as observed the 2NN study, translated into ‘health related quality of life’ (HRQoL). Design A sub-study with antiretro-viral-naive patients randomly allocated to NVP (once or twice daily), EFV NVP+EFV, addition stavudine lamivudine. Methods Comparing changes HRQoL over 48 weeks measured Medical Outcomes Study HIV Health Survey (MOS-HIV) questionnaire, using analysis variance. Results The...
Resistance-associated mutations (RAMs) in plasma samples from HIV-1-infected women who received antiretroviral (ARV) prophylaxis during pregnancy was assessed and correlated with the detection of RAMs peripheral blood mononuclear cells (PMBCs). The study population composed enrolled a prospective cohort Latin America Caribbean (NISDI Perinatal Study) as March 1, 2005, were diagnosed HIV-1 infection current pregnancy, ARVs for prevention mother-to-child transmission HIV-1, followed through at...
This study was aimed to determine the profiles of serum cytokines (IL-1β, TNF-α, IL-4, IL-5) and chemokines (MCP-1: monocyte chemoattract protein-1 RANTES: regulated on activation normal T cell expressed secreted) in individuals with an asthmatic versus a non-asthmatic background bacterial, viral or mixed acute respiratory infection. Asthmatic (n = 14) 29) patients viral, bacterial (bacterial viruses) infection were studied. Patients also analysed as pneumonia bronchitis. Healthy similar age...
Our objective was to estimate primary resistance in an urban setting a developing country characterized by high antiretroviral (ARV) coverage over the diagnosed population and also important proportion of undiagnosed individuals, order determine whether any change occurred past five years. We carried out multi-site surveillance study according WHO HIV guidelines, using weighted sampling technique based on annual case reports per site. Blood samples were collected from 197 drug-naive...
A case definition of HIV lipodystrophy has recently been developed from a combination clinical, metabolic and imaging/body composition variables using logistic regression methods. We aimed to evaluate whether artificial neural networks could improve the diagnostic accuracy.The database case-control Lipodystrophy Case Definition Study was split into 504 subjects (265 with 239 without lipodystrophy) used for training 284 independent (152 132 validation. Back-propagation one or two middle...
Objectives To investigate the ability of several HIV-1 drug-resistance interpretation systems, as well number pre-specified combinations abacavir-related mutations, to predict virological response abacavir-containing regimens in antiretroviral therapy-experienced, abacavir-naive patients starting an regimen EuroSIDA cohort. Patients and methods A total 100 HIV-infected with viral load (VL) >500 copies/ml who had a plasma sample available at time abacavir (baseline) were included....
AbstractBackground: Few published studies have considered both the short- and long-term virologic or immunologic response to combination antiretroviral therapy (cART) impact of different cART strategies. Purpose: To compare time initial (<500 copies/mL) (>200/mm3 cell increase) in antiretroviral-naïve patients starting either a single protease inhibitor (PI; n = 183), ritonavir-boosted PI regimen (&n 197), nonnucleoside reverse transcriptase (NNRTI)–based (n 447) after January 1, 2000, odds...
Abstract SARS-CoV-2, the novel Coronavirus, was first detected in Wuhan, China, December 2019, and has since spread rapidly, causing millions of deaths worldwide. As most countries world, Brazil, consequences COVID-19 pandemic have been catastrophic. The increasing decrease available beds hospitals, especially 2021, disturbed health authorities. Several studies reported fecal shedding SARS-CoV-2 RNA titers from infected symptomatic asymptomatic individuals. Therefore, quantification...
SARS-COV-2 VIRAL LOAD IN GOIÂNIA WASTEWATER: WASTEWATER-BASED EPIDEMIOLOGY FOR A COVID-19 EARLY WARNING SYSTEM. is currently the most critical disease in world. Thus, several tools have been used last two years to contain spread of SARS-CoV-2. In this perspective, Wastewater-Based Epidemiology (WBE) provides valuable data by including symptomatic, pre-symptomatic, and asymptomatic individuals anticipating clinical cases. For 37 weeks, SARS-CoV-2 viral load was monitored sanitary sewage...