A5079178548- Bacterial Infections and Vaccines
- Salmonella and Campylobacter epidemiology
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Infective Endocarditis Diagnosis and Management
- Herpesvirus Infections and Treatments
- Streptococcal Infections and Treatments
- Sepsis Diagnosis and Treatment
- Clostridium difficile and Clostridium perfringens research
- Infectious Encephalopathies and Encephalitis
- Infectious Diseases and Tuberculosis
- European and International Law Studies
- Vector-borne infectious diseases
- Reproductive tract infections research
- Education, Healthcare and Sociology Research
- Antimicrobial Resistance in Staphylococcus
- Listeria monocytogenes in Food Safety
- Bacteriophages and microbial interactions
- Urinary Tract Infections Management
Aalborg University Hospital
2016-2025
Aalborg University
2016-2025
European Society of Clinical Microbiology and Infectious Diseases
2020-2024
North Denmark Region
2024
Aarhus University Hospital
2010-2023
Zealand University Hospital
2023
Odense University Hospital
2006-2023
Nordsjællands Hospital
2021-2023
Rigshospitalet
2003-2023
Hvidovre Hospital
2006-2023
BackgroundSevere coronavirus disease 2019 (Covid-19) is associated with dysregulated inflammation. The effects of combination treatment baricitinib, a Janus kinase inhibitor, plus remdesivir are not known.MethodsWe conducted double-blind, randomized, placebo-controlled trial evaluating baricitinib in hospitalized adults Covid-19. All the patients received (≤10 days) and either (≤14 or placebo (control). primary outcome was time to recovery. key secondary clinical status at day 15.ResultsA...
A daily dose with 6 mg of dexamethasone is recommended for up to 10 days in patients severe and critical COVID-19, but a higher may benefit those more disease.To assess the effects 12 mg/d vs COVID-19 hypoxemia.A multicenter, randomized clinical trial was conducted between August 2020 May 2021 at 26 hospitals Europe India included 1000 adults confirmed requiring least L/min oxygen or mechanical ventilation. End 90-day follow-up on 19, 2021.Patients were 1:1 intravenous (n = 503) 497)...
Study Design. A randomized, prospective clinical study was conducted that included 119 patients with chronic neck pain of greater than 3 months' duration. Objectives. To compare the relative effectiveness intensive training cervical musculature, a physiotherapy treatment regimen, and chiropractic on this patient group. Summary Background Data. There are only few studies involving representative those seeking care in primary health centers. Mobilization techniques have been shown to be...
Community-acquired bacterial meningitis (CABM) is a life-threatening disease and timing of antibiotic therapy remains crucial. We aimed to analyse the impact on outcome CABM in contemporary cohort.We conducted population-based cohort study based chart reviews all adult cases (>16 years age) North Denmark from 1998 2014 excluding patients given pre-hospital parenteral antibiotics. used modified Poisson regression analyses compute adjusted risk ratio (adj. RR) with 95 % confidence intervals...
Schistosomiasis remains one of the most prevalent parasitic diseases worldwide and infection is frequently found in travelers migrants. The European Network for Tropical Medicine Travel Health conducted a sentinel surveillance study on imported schistosomiasis between 1997 2010. This report summarizes epidemiological clinical data from 1,465 cases schistosomiasis. Direct pathogen detection serology were main diagnostic tools applied. Of these, 486 (33%) identified among travelers, 231 (16%)...
There are limited data on outcomes of moderate to severe coronavirus disease 2019 (COVID-19) among patients treated with remdesivir and dexamethasone in a real-world setting. We sought compare the effectiveness standard care (SOC) alone versus SOC plus dexamethasone.Two population-based nationwide cohorts individuals hospitalized COVID-19 during February through December 2020 were studied. Death within 30 days need mechanical ventilation (MV) compared by inverse probability treatment...
BackgroundThe administration of broadly neutralising anti-HIV-1 antibodies before latency reversal could facilitate elimination HIV-1-infected CD4 T cells. We tested this concept by combining the antibody 3BNC117 in combination with latency-reversing agent romidepsin people HIV-1 who were taking suppressive antiretroviral therapy (ART).MethodsWe did a randomised, open-label, phase 2A trial at three university hospital centres Denmark, Germany, and USA. Eligible participants virologically...
Abstract Inducing antiretroviral therapy (ART)-free virological control is a critical step toward human immunodeficiency virus type 1 (HIV-1) cure. In this phase 2a, placebo-controlled, double-blinded trial, 43 people (85% males) with HIV-1 on ART were randomized to (1) placebo/placebo, (2) lefitolimod (TLR9 agonist)/placebo, (3) placebo/broadly neutralizing anti-HIV-1 antibodies (bNAbs) or (4) lefitolimod/bNAb. interruption (ATI) started at week 3. Lefitolimod was administered once weekly...
Clinical features applicable to the entire spectrum of viral meningitis are limited, and prognostic factors for adverse outcomes undetermined. This nationwide population-based prospective cohort study included all adults with presumed microbiologically confirmed in Denmark from 2015 until 2020. Prognostic an unfavourable outcome (Glasgow Outcome Scale score 1-4) 30 days after discharge were examined by modified Poisson regression. In total, 1066 episodes included, yielding a mean annual...
Soluble CD163 (sCD163) is a new macrophage-specific serum marker. This study investigated sCD163 and other markers of macrophage activation (neopterin, ferritin, transcobalamin, soluble urokinase plasminogen activator receptor [suPAR]) as prognostic factors in patients with pneumococcal bacteremia.Observational cohort study.Five university hospitals Denmark.A total 133 Streptococcus pneumoniae bacteremia (positive blood culture) age- gender-matched controls.Samples were collected for...
Malaria remains one of the most serious infections for travellers to tropical countries. Due lack harmonized guidelines a large variety treatment regimens is used in Europe treat severe malaria. The European Network Tropical Medicine and Travel Health (TropNet) conducted an 8-year, multicentre, observational study analyse epidemiology, practices outcomes malaria its member sites across Europe. Physicians at participating TropNet centres were asked report pseudonymized retrospective data from...
Knowledge of the epidemiology and clinical characteristics varicella zoster virus (VZV) encephalitis remains limited.Nationwide prospective cohort study adults treated for microbiologically confirmed VZV at Danish departments infectious diseases from 2015 to 2019. Modified Poisson regression analysis was used compute adjusted relative risks (RRs) unfavorable outcome.We identified 92 (49% female) with encephalitis, yielding an incidence 5.3/1 000 per year (95% CI, 4.2-6.6). Median age 75...
We aimed to determine the long-term risks of mortality and new-onset epilepsy after brain abscess.Using nationwide population-based medical registries, we examined all patients with first-time abscess in Denmark, 1982-2016. Comparison cohorts individually matched on age, sex, residence were identified, as siblings study participants. Next, computed cumulative incidences hazard rate ratios (HRRs) 95% confidence intervals among populations.We identified 1384 (37% females) a median follow-up...
Abstract Background Knowledge on risk factors for brain abscess is limited and relies single-center cohort studies. Methods We accessed nationwide medical registries to conduct a population-based, nested case-control study of abscess. applied risk-set sampling the selection population controls (1:10), who were individually matched by age, sex, area residence. Conditional logistic regression was used compute adjusted odds ratios (aOR) with 95% confidence intervals (CIs)....
Abstract Background Venous thromboembolism (VTE) is a potentially fatal complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and thromboprophylaxis should be balanced against risk bleeding. This study examined risks VTE major bleeding in hospitalized community-managed SARS-CoV-2 patients compared with control populations. Methods Using nationwide population-based registries, 30-day positive were those test-negative an external cohort influenza patients....
Studies on brain abscess are hampered by single-centre design with limited sample size and incomplete follow-up. Thus, robust analyses clinical prognostic factors remain scarce. This Danish nationwide, population-based cohort study included details of all adults (≥18 years) diagnosed in the National Patient Registry from 2007 through 2014 prospective database Study Group Infections Brain covering departments infectious diseases 2015 2020. All patients were followed for 6 months after...
Invasive pneumococcal disease is a serious infection that primarily affects very young children and elderly or immunocompromised individuals but also previously healthy people. Variant mannose-binding lectin (MBL) alleles are associated with recurrent infections may be risk factor for infections. To assess the influence of MBL genotypes on course outcome invasive disease, clinical data 141 adult patients were collected prospectively their determined. All included had positive blood cultures...
AbstractYKL-40 is secreted by activated macrophages and neutrophils. Elevated serum concentrations of YKL-40 are found in patients with diseases characterized inflammation or ongoing fibrosis. The aim this study was to evaluate levels Streptococcus pneumoniae bacteremia correlate these clinical findings outcomes. determined ELISA 89 were included the study. Serum significantly higher S. (median 342 μg/l; range 20-20,400 μg/l) than age-matched healthy subjects (44 20-184; p < 0.001). related...
Coinfection with hepatitis C virus (HCV) in human immunodeficiency (HIV) type 1-infected patients may decrease the effectiveness of highly active antiretroviral therapy. We determined impact HCV infection on response to therapy and outcome among Danish HIV-1 infection.This prospective cohort study included all adult HIV-1-infected who started from 1 January 1995 2004. Patients were classified as positive (positive serological test and/or PCR results [443 [16%]]), negative (consistent [2183...