A5013826629- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Emergency and Acute Care Studies
- COVID-19 and healthcare impacts
- Biomarkers in Disease Mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Use and Resistance
- COVID-19 Impact on Reproduction
- Nosocomial Infections in ICU
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Chronic Disease Management Strategies
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Bacterial Identification and Susceptibility Testing
- Diabetes Treatment and Management
- Urinary Tract Infections Management
- Biosensors and Analytical Detection
- Clostridium difficile and Clostridium perfringens research
- Antibiotics Pharmacokinetics and Efficacy
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Inflammasome and immune disorders
Copenhagen University Hospital
2013-2025
Hvidovre Hospital
2019-2025
University of Copenhagen
2013-2022
Amager Hospital
2020-2022
Rigshospitalet
2013-2015
There are limited data on outcomes of moderate to severe coronavirus disease 2019 (COVID-19) among patients treated with remdesivir and dexamethasone in a real-world setting. We sought compare the effectiveness standard care (SOC) alone versus SOC plus dexamethasone.Two population-based nationwide cohorts individuals hospitalized COVID-19 during February through December 2020 were studied. Death within 30 days need mechanical ventilation (MV) compared by inverse probability treatment...
Incretin-based therapies, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase-4 inhibitors (DPP-4i), have been hypothesized to exert beneficial effects on COVID-19 outcomes due anti-inflammatory properties. In this population-based cohort study, we retrieved data from nationwide registries all individuals diagnosed with severe acute respiratory syndrome coronavirus 2 infection up 1 November 2020. For diabetes, examined the impact of use GLP-1 RAs (n = 370) DPP-4i...
The long pentraxin-3 (PTX3) is a key component of the humoral arm innate immune system. PTX3 produced locally in response to pro-inflammatory stimuli. To investigate levels and its use as biomarker patients with systemic inflammation, we developed solid-phase enzyme-linked immunosorbent assay based on novel anti-PTX3 monoclonal antibodies detecting high sensitivity. was applied 261 consecutive admitted an intensive care unit prospectively monitored inflammatory syndrome (SIRS). 100 blood...
Abstract Background Venous thromboembolism (VTE) is a potentially fatal complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and thromboprophylaxis should be balanced against risk bleeding. This study examined risks VTE major bleeding in hospitalized community-managed SARS-CoV-2 patients compared with control populations. Methods Using nationwide population-based registries, 30-day positive were those test-negative an external cohort influenza patients....
Importance Gram-negative bacteremia is a global health concern, and optimizing the transition from intravenous (IV) to oral antibiotics critical step in improving patient treatment resource utilization. Objective To assess association of switching within 4 days after initial blood culture with 90-day all-cause mortality compared prolonged IV antibiotic for patients uncomplicated gram-negative bacteremia. Design, Setting, Participants This cohort study conducted using target trial emulation...
It has recently been hypothesized that vitamin K could play a role in COVID-19. We aimed to test the hypotheses low status is common characteristic of patients hospitalized with COVID-19 compared population controls and predicts mortality patients. In cohort 138 controls, we measured plasma dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP), which reflects functional peripheral tissue. Forty-three died within 90 days from admission. patients, levels dp-ucMGP differed significantly...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease 2019 (COVID-19), is a worldwide emergency. Demographic, comorbidity laboratory determinants of death ICU admission were explored in all Danish hospitalised patients.National health registries used to identify hospitalized patients with COVID-19 diagnosis. We obtained demographics, Charlson Comorbidity Index (CCI), results on prognostic factors for using multivariate Cox proportional hazard regression...
The course of COVID-19 is unpredictable, ranging from asymptomatic to respiratory failure and death. Prognostic biomarkers are urgently needed. We hypothesized that long pentraxin PTX3 could be a valuable plasma biomarker due its essential role in inflammatory processes. In prospective hospitalized derivation cohort (<i>n</i> = 126) during the spring 2020, we measured within 4 days admission. predictive value mechanical ventilation (MV) 30-day mortality compared with clinical...
Background Immunosuppression may worsen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We conducted a nationwide cohort study of the effect exposure to immunosuppressants on prognosis SARS-CoV-2 infection in Denmark. Methods identified all test-positive patients from February 2020 October and linked healthcare data registers, including prescriptions for (immunosuppressant drugs). estimated relative risks hospital admission, intensive care unit (ICU) admission death...
Background. Chronic low-grade inflammation associated with a dysregulated adipose tissue might contribute to amplifying the inflammatory response in severe COVID-19. The aim of this study was examine association between levels circulating leptin and adiponectin severity mortality Methods. Serum were determined at admission 123 individuals confirmed COVID-19 their 90-day respiratory failure analyzed by logistic regression analysis expressed as odds ratios (ORs) 95% confidence intervals (CIs)....
Immune dysregulation with an excessive release of cytokines has been identified as a key driver in the development severe COVID-19. The aim this study was to evaluate initial cytokine profile associated 90-day mortality and respiratory failure cohort patients hospitalized COVID 19 that did not receive immunomodulatory therapy.
The pattern recognition molecule pentraxin-3 (PTX3) is a novel potential marker of prognosis, as elevated levels are associated with both disease severity and mortality in patients wide range conditions. However, the usefulness PTX3 prognostic biomarker general hospital setting unknown.The study cohort consisted 1326 unselected, consecutive (age >40 years) admitted to community Copenhagen, Denmark. Patients were followed until death or for median 11.5 years after admission. main outcome...
To explore whether short-course antibiotic therapy is efficient and safe in routine clinical settings among patients hospitalized with community-acquired pneumonia (CAP) who achieve an early response.During 2017-2019, we conducted a cohort study of admitted CAP to four hospitals Denmark. Data were prospectively gathered from medical records enriched data nationwide registries. In the present study, included response divided them into treatment groups based on duration, as decided by...
Abstract Passive immunotherapy with convalescent plasma may be the only available agent during early phases of a pandemic. Here, we report safety and efficacy high-titer for COVID-19 pneumonia. Double-blinded randomized multicenter placebo-controlled trial adult patients hospitalized The intervention was placebo saline allocated 2:1. primary outcome clinical status 14 days after evaluated on ordinal scale. registered at ClinicalTrials.Gov, NCT04345289, 14/04/2020. CCAP-2 terminated...
Markus Fallya* , Simone Israelsenb, Jacob Anhøjc, Thomas Benfieldb, Britta Tarpd, Lilian Koltee & Pernille Ravnfa Department of Internal Medicine, Section for Pulmonary Diseases, Herlev Gentofte Hospital, Hellerup, Denmark; b Infectious Amager Hvidovre Hvidovre, c Centre Diagnostic Investigation, Rigshospitalet, Copenhagen, d Centre, Silkeborg Regional Silkeborg, e Respiratory Medicine and Nordsjællands Hillerød, f Supervisor Denmark
The combined effectiveness of remdesivir and dexamethasone in subgroups hospitalised patients with COVID-19 is poorly investigated.In this nationwide retrospective cohort study, we included 3826 between February 2020 April 2021. primary outcomes were use invasive mechanical ventilation 30-day mortality, comparing a treated previous without dexamethasone. We used inverse probability treatment weighting logistic regression to assess associations progression mortality the two cohorts. analyses...
Age-related macular degeneration (AMD) has been associated with both systemic and ocular alterations of the immune system. In particular dysfunction complement factor H (CFH), a soluble regulator alternative pathway system, implicated in AMD pathogenesis. One ligands for CFH is long pentraxin 3 (PTX3), which produced locally retinal pigment epithelium (RPE). To test hypothesis that PTX3 relevant to immunohomeostasis may be pathogenesis, we measured plasma protein concentration analyzed...
Background Community-acquired pneumonia (CAP) is one of the leading causes healthcare utilisation and death worldwide. Treatment according to evidence-based clinical guidelines can reduce mortality, antibiotic exposure length hospital stay related CAP. Local problem Several studies, including a pilot study from our sites, indicate that physicians show low grade guideline adherence when managing patients with Methods To improve guideline-based treatment CAP admitted hospital, we designed...
Abstract Background Despite the availability of antimicrobial therapies, gram-negative bacteremia remains a significant cause morbidity and mortality on global level. Recent randomized controlled trials support shorter antibiotic treatment duration for individuals with uncomplicated bacteremia. The target trial framework using cloning approach utilizes real-world data but eliminates issue immortal time bias seen in observational studies by emulating analysis full adherence. Method A...
Abstract Introduction Coronavirus disease 2019 (COVID‐19) is caused by Severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). Fast, accurate, and simple blood‐based assays for quantification of anti‐SARS‐CoV‐2 antibodies are urgently needed to identify infected individuals keep track the spread disease. Methods The study included 33 plasma samples from 20 with confirmed COVID‐19 real‐time reverse‐transcriptase polymerase chain reaction 40 non‐COVID‐19 samples. Anti‐SARS‐CoV‐2...