Tomas Ø. Jensen
A5041413555- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- Mosquito-borne diseases and control
- SARS-CoV-2 detection and testing
- Viral Infections and Vectors
- COVID-19 and healthcare impacts
- Global Maternal and Child Health
- Malaria Research and Control
- COVID-19 and Mental Health
- Respiratory Support and Mechanisms
- COVID-19 Impact on Reproduction
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS drug development and treatment
- Antibiotic Use and Resistance
- Burkholderia infections and melioidosis
- Viral Infections and Outbreaks Research
- HIV/AIDS Research and Interventions
- Parasite Biology and Host Interactions
- Parasites and Host Interactions
- Hemodynamic Monitoring and Therapy
- Migration, Aging, and Tourism Studies
- Cardiovascular and exercise physiology
- Heparin-Induced Thrombocytopenia and Thrombosis
University of Copenhagen
2005-2025
Centre of Excellence for Health, Immunity and Infections
2022-2025
Rigshospitalet
2021-2025
Copenhagen University Hospital
2021-2024
Médecins Sans Frontières
2018-2024
Zealand University Hospital
2021-2023
Aarhus University Hospital
2023
Aarhus University
1997-2023
Nordsjællands Hospital
2020-2022
Oslo University Hospital
2021
There are limited data on outcomes of moderate to severe coronavirus disease 2019 (COVID-19) among patients treated with remdesivir and dexamethasone in a real-world setting. We sought compare the effectiveness standard care (SOC) alone versus SOC plus dexamethasone.Two population-based nationwide cohorts individuals hospitalized COVID-19 during February through December 2020 were studied. Death within 30 days need mechanical ventilation (MV) compared by inverse probability treatment...
To identify individual characteristics associated with serological COVID-19 vaccine responsiveness and the durability of vaccine-induced antibodies.Adults without history SARS-CoV-2 infection from Danish population scheduled for vaccination were enrolled in this parallel group, phase 4 study. Spike IgG Spike-ACE2-receptor-blocking antibodies measured at days 0, 21, 90, 180. Vaccine was categorized according to levels day 90 after first vaccination. Nondurable response defined as day-90...
Older age and chronic disease are important risk factors for developing severe COVID-19. At population level, vaccine-induced immunity substantially reduces the of COVID-19 hospitalization. However, relative impact humoral cellular on protection from breakthrough infection is not fully understood.In a study cohort 655 primarily older participants (median 63 years (IQR: 51-72)), we determined serum levels Spike IgG antibodies using Multiantigen Serological Assay quantified frequency...
Recently, reports of severe thromboses, thrombocytopenia, and hemorrhage in persons vaccinated with the chimpanzee adenovirus-vectored vaccine (ChAdOx1 nCoV-19, AZD1222, Vaxzevria; Oxford/AstraZeneca) against acute respiratory syndrome coronavirus 2 have emerged. We describe an otherwise healthy 30-year-old woman who developed ecchymosis, portal vein thrombosis, cerebral venous sinus thrombosis second week after she received ChAdOx1 nCoV-19 vaccine. Extensive diagnostic workup for...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease 2019 (COVID-19), is a worldwide emergency. Demographic, comorbidity laboratory determinants of death ICU admission were explored in all Danish hospitalised patients.National health registries used to identify hospitalized patients with COVID-19 diagnosis. We obtained demographics, Charlson Comorbidity Index (CCI), results on prognostic factors for using multivariate Cox proportional hazard regression...
Ensovibep (MP0420) is a designed ankyrin repeat protein, novel class of engineered proteins, under investigation as treatment SARS-CoV-2 infection.To investigate if ensovibep, in addition to remdesivir and other standard care, improves clinical outcomes among patients hospitalized with COVID-19 compared care alone.Double-blind, randomized, placebo-controlled, trial. (ClinicalTrials.gov: NCT04501978).Multinational, multicenter trial.Adults COVID-19.Intravenous 600 mg, or placebo.Ensovibep was...
SARS-CoV-2 Omicron quickly spread globally, also in regions with high vaccination coverage, emphasizing the importance of exploring immunological requirements for protection against breakthrough infection. The test-negative matched case-control study (N = 964) characterized infections triple-vaccinated individuals from ENFORCE cohort. Within 60 days before a PCR test spike-specific IgG levels were significantly lower cases compared to controls (GMR [95% CI] BA.2: 0.83 [0.73-0.95], p 0.006)....
Within a year of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, vaccines inducing robust humoral and cellular immune response were implemented worldwide. However, emergence novel variants waning vaccine-induced immunity led to implementation additional vaccine boosters.
Deferring ART until a CD4 count below cells/mm3 or other clinical indication in people with HIV (PWH) carries an increased risk of severe bacterial infections and tuberculosis (TB). It is not known if this reversed after initiation. We analyzed 4,684 adult PWH cell counts above 500 who were randomized to immediate deferred the Strategic Timing AntiRetrovial Treatment (START) trial. In May 2015, group was offered follow-up continued December 2021. Cox proportional hazards models used compare...
A rapid diagnosis is considered important in HIV care. In 138,911 testing episodes with the Abbott Architect Ag/Ab Combo assay (3,705 reactive samples), a signal-to-cutoff ratio of >151.17 had positive predictive value 100% and sensitivity 67.4% for detection subsequently confirmed infection. We suggest that results higher than this threshold may be reported to clinicians before completion confirmatory testing.
Neurocysticercosis is thought to be the most common helminthic infection of central nervous system and its epidemiology changing due increasing travel migration. Evidence guide management intraventricular form limited. We aimed review clinical presentation, diagnosis treatment neurocysticercosis with reference two recent cases seen at our institution. The variant less than parenchymal disease usually presents acutely raised intracranial pressure untreated it progresses rapidly high...
We describe an outbreak of respiratory syncytial virus (RSV) infection on a hematology ward without allogeneic stem cell transplant patients. Twelve patients and one staff member infected with RSV were identified from the laboratory database. Five had lower tract infection, seven upper was asymptomatic, there two (15.4%) deaths. Most overlapping periods potential infectiousness ward. Sequencing possible eight specimens five these identical sequences. Results consistent transmission occurring...
Patients admitted to the emergency care setting with COVID-19-infection can suffer from sudden clinical deterioration, but extent of deviating vital signs in this group is still unclear. Wireless technology monitors patient continuously and might detect deviations earlier than intermittent measurements. The aim study was determine frequency duration sign using continuous monitoring compared manual A secondary analysis compare patients ICU or having fatal outcome vs. those that were not.Two...
Using U.S. county-level migration data from the 2000 Census, we examine patterns of older people. This study makes three contributions to literature. First focus attention on differences in people by separately modeling four age classifications. Second, using Geographically Weighted Regression (GWR), look for and find significant spatial variation determinants Third, because many migrants relocate purely quality life, role amenities, both natural built, explaining patterns.
OBJECTIVE To evaluate the impact of early infectious diseases (ID) antimicrobial stewardship (AMS) intervention on inpatient sepsis antibiotic management. DESIGN Interventional, nonrandomized, controlled study. SETTING Tertiary-care referral hospital, Sydney, Australia. PATIENTS Consecutive, adult, non–intensive care unit (non-ICU) inpatients triggering an institutional clinical pathway from May to August 2015. INTERVENTION All patients reviewed by ID Fellow within 24 hours trigger underwent...
Severe-febrile-illness (SFI) is a common cause of morbidity and mortality across sub-Saharan Africa (SSA). The burden SFI in SSA currently unknown its estimation fraught with challenges. This due to lack diagnostic capacity for SSA, thus dearth baseline data on the underlying etiology cases scant SFI-specific causative-agent prevalence data. To highlight public health significance we developed Bayesian model quantify incidence hospital admissions SSA. Our estimates indicate mean...
The combined effectiveness of remdesivir and dexamethasone in subgroups hospitalised patients with COVID-19 is poorly investigated.In this nationwide retrospective cohort study, we included 3826 between February 2020 April 2021. primary outcomes were use invasive mechanical ventilation 30-day mortality, comparing a treated previous without dexamethasone. We used inverse probability treatment weighting logistic regression to assess associations progression mortality the two cohorts. analyses...