A5016179415- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular and exercise physiology
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Heart Rate Variability and Autonomic Control
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Nutrition and Health in Aging
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Chronic Disease Management Strategies
- Body Composition Measurement Techniques
- Nosocomial Infections in ICU
- Iron Metabolism and Disorders
- Diabetes and associated disorders
- Cardiac Health and Mental Health
- Transplantation: Methods and Outcomes
- Pancreatitis Pathology and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Esophageal and GI Pathology
- Biomarkers in Disease Mechanisms
- Adrenal Hormones and Disorders
- Child Nutrition and Feeding Issues
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Diabetes Management and Research
Copenhagen University Hospital
2021-2025
Rigshospitalet
2017-2025
Zealand University Hospital
2022-2024
University of Copenhagen
2017-2024
Nordsjællands Hospital
2020-2023
Danish Business Authority
2018
Blood volume (BV) is an important clinical parameter and usually reported per kg of body mass (BM). When fat elevated, this underestimates BV/BM. One aim was to study if differences in BV/BM related sex, age, fitness would decrease normalized lean (LBM). The analysis included 263 women 319 men (age: 10-93 years, index: 14-41 kg/m
Limb muscle dysfunction in patients with COPD may be associated local and/or systemic inflammation, and therefore we investigated whether exercise training altered markers of inflammation oxidative stress. We obtained vastus lateralis biopsies venous blood samples from (n = 30) before after 8 weeks resistance ( RT ) 15) or endurance ET 15). Healthy age‐matched subjects were included as baseline controls 8). Inflammatory systemically determined by interleukins IL ), tumour necrosis factor...
Abstract Objective To investigate the effect of standard care (SoC) combined with supervised in-bed cycling (Bed-Cycle) or booklet exercises (Book-Exe) versus SoC in community-acquired pneumonia (CAP). Methods In this randomized controlled trial, 186 patients CAP were assigned to (n = 62), Bed-Cycle 61), Book-Exe 63). Primary outcome length stay (LOS) was analyzed analysis covariance. Secondary outcomes, 90-day readmission, and 180-day mortality Cox proportional hazard regression readmission...
Objective. To investigate the change in diffusing capacity from rest to submaximal exercise patients with mild severe COPD compared a healthy, age- and sex matched control group, if can be altered by high-intensity interval training (HIIT). Methods. 35 15 healthy controls were included. Pulmonary was measured using combined single-breath method carbon monoxide nitric oxide (D L,CO,NO ), which at during 60% of peak workload (W Lpeak ) estimate alveolar-capillary reserve (change exercise). A...
Hypoxia increases heart rate (HR) in humans by sympathetic activation and vagal withdrawal. However, anaesthetized dogs hypoxia activity reduces HR if pulmonary ventilation does not increase we evaluated whether that observation applies to awake humans. Ten healthy males were exposed 15 min of normoxia (10.5% O2), while respiratory tidal volume volitionally controlled at values identified during spontaneous breathing hypoxia. End-tidal CO2 tension was clamped 40 mmHg supplementation....
High-intensity interval training (HIIT) has shown to improve exercise capacity, symptom burden, and quality of life in COPD patients, but it remains be investigated if HIIT can counteract limb muscle dysfunction. Therefore, we examined the impact a 12-week supervised protocol on oxygen conductance. Eight patients with mild moderate eight age-, sex- BMI-matched controls underwent intervention. Leg blood flow (Q̇ leg ) arterio-venous samples were collected at rest during active single-leg knee...
Abstract Background Different pathogens can cause community-acquired pneumonia (CAP); however, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing disease 2019 (COVID-19) has re-emphasized vital role of viruses as a CAP. The aim was to explore differences in metabolic profile, body composition, physical capacity, and inflammation between patients hospitalized with CAP caused by different etiology. Methods A prospective study Danish SARS-CoV-2, influenza, or...
Skeletal muscle blood flow is regulated to match the oxygen demand and dysregulation could contribute exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). We measured leg hemodynamics metabolites from vasoactive compounds interstitial fluid plasma at rest, during one-legged knee-extensor exercise, arterial infusions of sodium nitroprusside (SNP) acetylcholine (ACh), respectively. Ten moderate severe COPD eight age- sex-matched healthy controls were studied....
Background: Impaired functional status is a risk factor for hospitalization in patients with community-acquired pneumonia (CAP). The aim was to determine the influence of and physical activity level on severe outcomes, including length stay, admission intensive care unit (ICU), readmission, mortality CAP. Methods: A prospective cohort study among hospitalized Functional assessed Barthel index grip strength, using international questionnaire. Linear regression used assess association logistic...
Breathlessness during daily activities is the primary symptom in patients with heart failure (HF). Poor correlation between hemodynamic parameters of left ventricular performance and perceived symptoms suggests that other factors, such as skeletal muscle function, play a role determining exercise capacity. We investigated effect 6 wk high-intensity, one-legged cycling (HIC; 8 × 4 at 90% max) on 1) ability to override sympathetic vasoconstriction (arterial infusion tyramine) knee-extensor...
Ferritin, the central iron storage protein, has attracted attention as a biomarker of severe COVID-19. Few studies have investigated regulators metabolism in context The aim was to evaluate biomarkers for acute phase response community-acquired pneumonia (CAP) caused by SARS-CoV-2 compared with CAP bacteria or influenza virus hospitalized patients. A cross-sectional study 164 patients from Surviving Pneumonia Cohort recruited between January 8, 2019 and May 26, 2020. Blood samples were...
Background: Bed rest with limited physical activity is common during admission. The aim was to determine the association between daily step count and levels after admission community-acquired pneumonia (CAP) risk of readmission mortality. Methods: A prospective cohort study 166 patients admitted CAP. Step were assessed accelerometers categorised as sedentary, light, or moderate-vigorous activity. Linear regression used assess length stay. Logistic count, level, Results: Patients CAP light...
Aim: Skeletal muscle convective and diffusive oxygen (O 2 ) transport are peripheral determinants of exercise capacity in both patients with chronic obstructive pulmonary disease (COPD) heart failure (CHF). We hypothesised that differences these performance between COPD CHF revealed during small mass exercise, where the cardiorespiratory limitations to diminished. Methods: Eight moderate severe COPD, eight (NYHA II), age- sex-matched controls were studied. measured leg blood flow (Q̇ by...
Sympathetic vasoconstriction is blunted in exercising muscle (functional sympatholysis) but becomes attenuated with age. We tested the hypothesis that functional sympatholysis further impaired chronic obstructive pulmonary disease (COPD) patients. determined leg blood flow and calculated vascular conductance (LVC) during 1) femoral-arterial Tyramine infusion (evokes endogenous norepinephrine release, 1 µmol·min −1 ·kg mass ), 2) one-legged knee extensor exercise without [10 W 20% of maximal...
Introduction Diabetes is associated with dysregulated immune function and impaired cytokine release, while transient acute hyperglycaemia has been shown to enhance inflammatory release in preclinical studies. Although diabetes are common among patients community-acquired pneumonia (CAP), the impact of chronic, acute, acute-on-chronic on host response within this population remains poorly understood. This study investigated whether acute-on- chronic distinct mediators inflammatory,...
Community-acquired pneumonia (CAP) in chronic obstructive pulmonary disease (COPD) often result sudden and persistent reduction health-related quality of life (HRQoL), which may be alleviated with palliative care. Among individuals COPD, we aimed to investigate potential associations between HRQoL at admission CAP the risk re-hospitalization mortality specific domains treatment outcomes. was assessed participants were grouped into tertiles based on utility index domains. The results revealed...
Abstract Background Community-acquired pneumonia (CAP) is a leading cause of hospitalization worldwide. Bed rest with low levels physical activity common during periods and leads to functional decline as well increased risk complications. The aim this study assess the effect supervised training CAP compared standard usual care for on length hospital stay, readmission, mortality risk, capacity, muscle fat mass, strength, metabolic function, systemic inflammation, health-related quality life,...
Undernutrition is associated with increased mortality after hospitalization community-acquired pneumonia (CAP), whereas obesity decreased in most studies. We aimed to determine whether undernutrition and are risk of re-hospitalization post-discharge hospitalization. This study was nested within the Surviving Pneumonia cohort, which a prospective cohort adults hospitalized CAP. Patients were categorized as undernourished, well-nourished, overweight, or obese. based on diagnostic criteria by...