A5085166967- Transplantation: Methods and Outcomes
- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory and Cough-Related Research
- Pharmacological Effects and Assays
- Polyomavirus and related diseases
- Inorganic and Organometallic Chemistry
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Organ and Tissue Transplantation Research
- Tuberous Sclerosis Complex Research
- Ultrasound in Clinical Applications
- Respiratory Support and Mechanisms
- Long-Term Effects of COVID-19
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Sarcoidosis and Beryllium Toxicity Research
- Inhalation and Respiratory Drug Delivery
- Pulmonary Hypertension Research and Treatments
- Pediatric health and respiratory diseases
- Occupational Health and Safety Research
- Mesenchymal stem cell research
Rigshospitalet
1990-2025
Copenhagen University Hospital
2008-2025
University of Copenhagen
2023-2025
Odense University Hospital
2024
University of Southern Denmark
2024
Gentofte Hospital
2023
University of Pennsylvania
2022
Danish National Research Foundation
2018
Bispebjerg Hospital
2007-2014
Danish National Centre for Social Research
2009
Patients who have undergone double lung transplantation (DLTx) are at increased risk of pulmonary thromboembolism (PTE). Although the presence clinically overt PTE can adversely affect short-term mortality, prognostic impact asymptomatic (silent) detected by routine imaging after DLTx is unclear. This study aimed to determine whether identified ventilation-perfusion single-photon emission computed tomography (V̇-Q̇ SPECT) 12 weeks post-DLTx associated with subsequent all-cause and...
Background: The aim of this study was to describe differences between allergic rhinitis (AR) and nonallergic (NAR) in a large community‐based sample Danish adolescents adults. Methods: A total 1186 subjects, 14–44 years age, who screening questionnaire had reported history airway symptoms suggestive asthma and/or allergy, or were taking any medication for these conditions clinically examined. All participants interviewed about respiratory furthermore skin test reactivity, lung function...
Asthma may be defined as eosinophilic or non-eosinophilic based on the presence of eosinophils in sputum. Recently a further classification into four inflammatory subtypes has been suggested. The aim present study was to describe association between these and markers airway inflammation hyperresponsiveness. In 62 adult non-smoking asthmatics, (18-65 yr) not taking inhaled steroids, sputum induction, bronchial challenge with mannitol measurement exhaled NO (eNO) were performed. Based...
Most cystic fibrosis (CF) patients referred for lung transplantation are chronically infected with Gram-negative opportunistic pathogens. It is well known that chronic infections in CF have a significant impact on lung-function decline and survival before transplantation. The rate timing of re-colonization after been described, but the stratification bacteria not elucidated. We did single-center retrospective analysis 99 consecutive who underwent since beginning Copenhagen Lung Transplant...
Abstract Objectives Improved survival after hematopoietic cell transplantation (HCT) and an increasingly comorbid transplant population may give rise to new trends in the causes of death. Methods This study includes all adult allogeneic HCT recipients transplanted at Rigshospitalet between January 1, 2010 December 31, 2019. Underlying death were determined using Classification Death Causes Transplantation (CLASS) method. Results Among 802 recipients, 289 died during period. The main relapse...
Monitoring specific underlying causes of death in solid organ transplant (SOT) recipients is important order to identify emerging trends and health challenges. This retrospective cohort study includes all SOT transplanted at Rigshospitalet between January 1st, 2010 December 31st, 2019. The cause was determined using the newly developed Classification Death Causes after Transplantation (CLASS) method. Cox regression analyses assessed risk factors for all-cause cause-specific mortality. Of...
Primary graft dysfunction (PGD) is common in lung transplantation affecting 15-30% of recipients. It represents a multifactorial injury to the transplanted within first 72 hours after transplantation.We aimed investigate clinical safety and efficacy allogeneic adipose tissue-derived stromal cells (ASCs), as an add-on therapy patients undergoing double transplantation. Single center, double-blinded, investigator-initiated randomized phase I/II study with intravenous infusion either ASCs or...
Objective. To investigate the change in diffusing capacity from rest to submaximal exercise patients with mild severe COPD compared a healthy, age- and sex matched control group, if can be altered by high-intensity interval training (HIIT). Methods. 35 15 healthy controls were included. Pulmonary was measured using combined single-breath method carbon monoxide nitric oxide (D L,CO,NO ), which at during 60% of peak workload (W Lpeak ) estimate alveolar-capillary reserve (change exercise). A...
The objective was to determine the prevalence of asthma‐like symptoms and asthma use medication in Danish elite athletes. A cross‐sectional questionnaire survey athletes conducted 2006. All ( N =418) financially supported by national organization comprised study group; 329 (79%) completed concerning their sport, symptoms, medication. Asthma‐like at rest were reported 41% respondents; 55% or exercise. Physician‐diagnosed present 16% 14% had current asthma. Asthma taken 7% athletes, whom 79%...
Multiple myeloma (MM) is a clonal plasma cell proliferative malignancy characterized by debilitating bone disease. Osteolytic destruction, hallmark of MM, driven increased osteoclast number and exacerbated resorption, primarily fueled the excessive production RANKL, master regulator formation, within tumor niche. We previously reported that osteocytes, most abundant cells in niche, promote progression support MM disease overproducing RANKL. However, molecular mechanisms underlying RANKL...
Background: Asthma is frequent in elite athletes and clinical studies have found increased airway inflammation. Objective: To investigate asthma-like symptoms, inflammation, reactivity (AR) to mannitol use of asthma medication Danish athletes. Methods: The study group consisted 54 (19 with doctor-diagnosed asthma), 22 non-athletes (steroid naive for 4 weeks before the examination) 35 without asthma; all aged 18–35 years. Examinations (1 day): questionnaires, exhaled nitric oxide (eNO) parts...
Data on blood and urinary concentrations of salbutamol after inhalation oral administration in healthy subjects are scarce. Accordingly, we examined the pharmacokinetics inhaled asthmatic subjects.We enrolled 10 men aged 18-45 yr an open-label study which 0.8 mg or 8 systemic was administered a crossover design. All had doctor-diagnosed asthma, used beta2 agonist when needed, abstained from any medicine, inclusive, for 14 d before visit. Urine collected all (0-4, 4-8, 8-12 h), samples were...
Self-reported noise exposure is on the rise in Denmark. Little known, however, about social consequences, including sickness absence, of exposure. The aim this paper was to investigate association between self-reported and long-term absence. investigated using Cox proportional hazards model analyze outcomes Danish register data basis survey (5357 employees aged 18-69 2000). analyses showed that significantly associated with absence for both men women when adjusting demographic factors health...
Abstract Many patients exhibit persistently reduced pulmonary diffusing capacity after coronavirus disease 2019 (COVID‐19). In this study, dual test gas for carbon monoxide and nitric oxide ( D L,CO,NO ) metrics their relationship to severity physical performance were examined in who previously had COVID‐19. An initial cohort of 148 diagnosed with COVID‐19 all severities between March 2020 2021 a measurement performed using the single‐breath method at 5.7 months follow‐up. All least one...
Correct classification of death causes is an important component transplant trials. We aimed to develop and validate a system classify in hematopoietic stem cell (HSCT) solid organ (SOT) recipients. Case record forms (CRF) fatal cases were completed, including investigator-designated cause death. Deaths occurring 2010 2013 used for derivation; validated by deaths 2015. Underlying (referred as recorded underlying cause) was determined through central adjudication process involving 2 external...