A5059403151- Traumatic Brain Injury and Neurovascular Disturbances
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Cardiovascular and exercise physiology
- Heart Rate Variability and Autonomic Control
- Intensive Care Unit Cognitive Disorders
- Optical Imaging and Spectroscopy Techniques
- Transplantation: Methods and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Immune Response and Inflammation
- COVID-19 Clinical Research Studies
- Neuroscience of respiration and sleep
- Venous Thromboembolism Diagnosis and Management
- Innovative Teaching Methods
- Pulmonary Hypertension Research and Treatments
- High Altitude and Hypoxia
- Acute Ischemic Stroke Management
- Exercise and Physiological Responses
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Thermal Regulation in Medicine
- Neonatal Respiratory Health Research
- Innovations in Medical Education
University of Copenhagen
2014-2025
University of South Wales
2009-2025
Copenhagen University Hospital
2009-2025
Rigshospitalet
2016-2025
Bispebjerg Hospital
2016-2025
Naturalis Biodiversity Center
2024
UNSW Sydney
2023-2024
Capital Region of Denmark
2013-2024
University of Reading
2019
University College Cork
2019
According to animal studies, intake of probiotic bacteria may improve glucose homeostasis. We hypothesised that insulin sensitivity by attenuating systemic inflammation. Therefore, the effects oral supplementation with bacterium Lactobacillus acidophilus NCFM on and inflammatory response were investigated in subjects normal or impaired sensitivity. In a double-blinded, randomised fashion, forty-five males type 2 diabetes, tolerance enrolled allocated 4-week treatment course either L....
Background Many people recovering from coronavirus disease 2019 (COVID-19) experience prolonged symptoms, particularly breathlessness. We urgently need to identify safe and effective COVID-19 rehabilitative strategies. The aim of the current study was investigate potential role inspiratory muscle training (IMT). Methods 281 adults (age 46.6±12.2 years; 88% female) self-reported (9.0±4.2 months post-acute infection) were randomised 4:1 an 8-week IMT or a “usual care” waitlist control arm....
BackgroundSevere immunopathology may drive the deleterious manifestations that are observed in advanced stages of coronavirus disease 2019 (COVID-19) but poorly understood.ObjectiveOur aim was to phenotype leukocyte subpopulations and cytokine milieu lungs blood critically ill patients with COVID-19 acute respiratory distress syndrome (ARDS).MethodsWe consecutively included less than 72 hours after intubation following informed consent from their next kin. Bronchoalveolar lavage fluid...
Abstract Background Cardiopulmonary exercise testing (CPET) is usually considered the gold standard for assessing maximal oxygen consumption (V̇O 2max ), a health and performance marker in patients with chronic obstructive pulmonary disease (COPD). Despite widespread application of CPET, absolute relative test‐retest reliability CPET‐derived metrics remains unexamined. Objective To examine compare CPET derived individuals COPD healthy matched controls. Methods 12 age‐ sex‐matched controls...
Patients who have undergone double lung transplantation (DLTx) are at increased risk of pulmonary thromboembolism (PTE). Although the presence clinically overt PTE can adversely affect short-term mortality, prognostic impact asymptomatic (silent) detected by routine imaging after DLTx is unclear. This study aimed to determine whether identified ventilation-perfusion single-photon emission computed tomography (V̇-Q̇ SPECT) 12 weeks post-DLTx associated with subsequent all-cause and...
This study examined whether hypoxia causes free radical-mediated disruption of the blood-brain barrier (BBB) and impaired cerebral oxidative metabolism this has any bearing on neurological symptoms ascribed to acute mountain sickness (AMS). Ten men provided internal jugular vein radial artery blood samples during normoxia 9-h passive exposure (12.9% O(2)). Cerebral flow was determined by Kety-Schmidt technique with net exchange calculated Fick principle. AMS headache were clinically...
Systemic inflammation is often associated with impaired glucose metabolism. We therefore studied the activation of inflammatory pathway intermediates that interfere uptake during systemic by applying a standardised stimulus in vivo. After ethical approval, informed consent and thorough physical examination, 10 patients type 2 diabetes participants normal tolerance (NGT) were given an intravenous bolus E. coli lipopolysaccharide (LPS) 0.3 ng/kg. Skeletal muscle biopsies plasma obtained at...
Abstract To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure of dipalmitoylphosphatidylcholine (DPPC). A total eleven patients with moderate-to-severe ARDS (CARDS) 15 healthy controls were included. CARDS had lower DPPC controls. Moreover, a principal component analysis was able separate patient groups into distinguishable subgroups. Our...
Abstract We examined the extent to which apnoea‐induced extremes of oxygen demand/carbon dioxide production impact redox regulation cerebral bioenergetic function. Ten ultra‐elite apnoeists (six men and four women) performed two maximal dry apnoeas preceded by normoxic normoventilation, resulting in severe end‐apnoea hypoxaemic hypercapnia, hyperoxic hyperventilation designed ablate hypoxaemia, hyperoxaemic hypercapnia. Transcerebral exchange ascorbate radicals (by electron paramagnetic...
Abstract Background Plasma follistatin is elevated in patients with low‐grade inflammation and insulin resistance as observed polycystic ovary syndrome. In the present study, we evaluated plasma type 2 diabetes characterised by assessed acute effects of hyperglycemia, hyperinsulinemia LPS on follistatin. Methods Baseline inflammatory biomarkers were measured a cross‐sectional study that involved 95 103 matched controls. To determine effect hyperglycemia follistatin, hyperglycemic...
Abstract The mean flow index—usually referred to as Mx—has been used for assessing dynamic cerebral autoregulation (dCA) almost 30 years. However, concerns have arisen regarding methodological consistency, construct and criterion validity, test–retest reliability. Methodological nuances, such choice of input (cerebral perfusion pressure, invasive or non‐invasive arterial pressure), pre‐processing approach artefact handling, significantly influence index values, previous studies correlating...
Systemic low-grade inflammation is recognized in an increasing number of chronic diseases. With the aim establishing experimental human vivo model systemic inflammation, we measured circulating inflammatory mediators after intravenous administration Escherichia coli endotoxin (0.3 ng/kg body weight) either as a bolus injection or 4-h continuous infusion, well saline administration, 10 healthy male subjects on three separate study days. Only caused increase heart rate, whereas slight rectal...
Abstract CD163 is the macrophage receptor for uptake of hemoglobin-haptoglobin complexes. The human can be shed from surface owing to a cleavage site inflammation-inducible TACE/ADAM17 enzyme. Accordingly, plasma ‘soluble CD163’ (sCD163) has become biomarker activity and inflammation. present study disclosed that 10% sCD163 in healthy persons actually extracellular vesicle (EV)-associated not being cleaved shed. Endotoxin injection volunteers caused selective increase ectodomain CD163, while...
Understanding of strategies to support individuals recovering from coronavirus disease 2019 (COVID-19) is limited. 'Long COVID' a multisystem characterised by range respiratory, gastrointestinal, cardiovascular, neurological, and musculoskeletal symptoms extending beyond 12 weeks. The aim this study was explore individuals' experiences COVID-19 provide better understanding the acute long-term impact on physical activity (PA). Individualised semi-structured interviews were conducted with 48...
Abstract Doppler ultrasound may be used to assess leg blood flow (), but the reliability of this method remains unexplored in patients with chronic obstructive pulmonary disease (COPD), where between‐subject variability larger than healthy due peripheral vascular changes. This study aimed investigate quantifying during single‐leg knee‐extensor exercise (KEE) COPD compared those obtained from matched controls. In case–control study, 16 participants were based on sex and age All underwent...
Sepsis is frequently complicated by brain dysfunction, which may be associated with disturbances in cerebral autoregulation, rendering the susceptible to hypoperfusion and hyperperfusion. The purpose of present study was assess static dynamic autoregulation 1) a human experimental model systemic inflammatory response during early sepsis 2) patients advanced sepsis. Cerebral tested using transcranial Doppler ultrasound healthy volunteers (n = 9) before after LPS infusion 16). Static...
Aim The aim of this study was to examine if erythropoietin (EPO) has the potential act as a biological antioxidant and determine underlying mechanisms. Methods rate at which its recombinant form (rHuEPO) reacts with hydroxyl (HO˙), 2,2-diphenyl-1-picrylhydrazyl (DPPH˙) peroxyl (ROO˙) radicals evaluated in-vitro. relationship between erythopoietic oxidative–nitrosative stress response poikilocapneic hypoxia determined separately in-vivo by sampling arterial blood from eleven males in normoxia...