A5025155739- Virus-based gene therapy research
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Viral Infections and Outbreaks Research
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- NF-κB Signaling Pathways
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Immune responses and vaccinations
- T-cell and B-cell Immunology
- Hemoglobin structure and function
- Pediatric health and respiratory diseases
- Cancer Immunotherapy and Biomarkers
- Reproductive Physiology in Livestock
- Viral Infections and Immunology Research
- Medical Device Sterilization and Disinfection
- Single-cell and spatial transcriptomics
- Endometriosis Research and Treatment
- Lipid Membrane Structure and Behavior
- Clostridium difficile and Clostridium perfringens research
- Atherosclerosis and Cardiovascular Diseases
- Reproductive tract infections research
- Pregnancy and Medication Impact
- Erythrocyte Function and Pathophysiology
CureVac (Germany)
2017-2022
Aix-Marseille Université
2013-2017
Centre d’Immunologie de Marseille-Luminy
2013-2017
Inserm
2013-2017
Centre National de la Recherche Scientifique
2013-2017
Institut Jacques Monod
2007-2014
Université Paris Cité
2013-2014
Délégation Paris 7
2013
Abstract mRNA represents a promising new vaccine technology platform with high flexibility in regard to development and production. Here, we demonstrate that vaccines based on sequence optimized, chemically unmodified formulated optimized lipid nanoparticles (LNPs) are highly immunogenic well tolerated non-human primates (NHPs). Single intramuscular vaccination of NHPs LNP-formulated mRNAs encoding rabies or influenza antigens induced protective antibody titers, which could be boosted...
Abstract CD163 is the macrophage receptor for uptake of hemoglobin-haptoglobin complexes. The human can be shed from surface owing to a cleavage site inflammation-inducible TACE/ADAM17 enzyme. Accordingly, plasma ‘soluble CD163’ (sCD163) has become biomarker activity and inflammation. present study disclosed that 10% sCD163 in healthy persons actually extracellular vesicle (EV)-associated not being cleaved shed. Endotoxin injection volunteers caused selective increase ectodomain CD163, while...
Background Engineered arenavirus vectors have recently been developed to leverage the body’s immune system in fight against chronic viral infections and cancer. Vectors based on Pichinde virus (artPICV) lymphocytic choriomeningitis (artLCMV) encoding a non-oncogenic fusion protein of human papillomavirus (HPV)16 E6 E7 are currently being tested patients with HPV16+ cancer, showing favorable safety tolerability profile unprecedented expansion tumor-specific CD8 + T cells. Although strong...
The spleen plays an important role in protective immunity to bloodborne pathogens. Macrophages and dendritic cells (DCs) the marginal zone capture microbial antigens trigger adaptive immune responses. Marginal macrophages (MZMs) can also act as a replicative niche for intracellular pathogens, providing platform mounting response. Here, we describe RANK coordinated function of antigen-presenting triggering anti-viral immunity. Targeted deletion results selective loss CD169+ MZMs, which...
Despite much interest in the mechanisms regulating fetal-maternal interactions, information on leukocyte populations and major cytokines present uterus placenta remains fragmentary. This report presents a detailed quantitative study of at mouse interface, including comparison between pregnancies from syngeneic allogeneic crosses. Our results provide evidence for drastic differences not only composition during pregnancy, but also uterine placental tissues. Interestingly, we have observed...
Infection with human papillomavirus (HPV) is associated a variety of cancer types and limited therapy options. Therapeutic vaccines targeting the HPV16 oncoproteins E6 E7 have recently been extensively explored as promising immunotherapy approach to drive durable antitumor T cell immunity induce effective tumor control. With goal achieve potent lasting responses, we generated novel lymphocytic choriomeningitis virus (LCMV)-based vaccine, TT1-E7E6, E7. This replication-competent vector was...
Background The Ikkα kinase, a subunit of the NF-κB-activating IKK complex, has emerged as an important regulator inflammatory gene expression. However, role Ikkα-mediated phosphorylation in haematopoiesis and atherogenesis remains unexplored. In this study, we investigated effect bone marrow (BM)-specific activation-resistant mutant knock-in on atherosclerosis mice. Methods Results Apolipoprotein E (Apoe)-deficient mice were transplanted with BM carrying (IkkαAA/AAApoe−/−) or Ikkα+/+Apoe−/−...
Immunotherapy has revolutionized cancer treatment in recent years. Although currently approved checkpoint inhibitors (CPIs) yield remarkable anti-tumoral responses several types, a substantial proportion of patients do not benefit from such therapies. Local activation innate immune signaling pathways is promising approach to overcome the immunosuppressive tumor microenvironment, induce anti-tumor immunity, and improve efficacy CPI Here, we assessed mode action RNA-based stimulator CV8102 for...
The obligate intracellular bacterium Chlamydia exists as two distinct forms. Elementary bodies (EBs) are infectious and extra-cellular, whereas reticulate (RBs) replicate within a specialized compartment termed an 'inclusion'. Alternative persistent intra-cellular forms can be induced in culture by diverse stimuli such IFNγ or adenosine/EHNA. They do not grow divide but revive upon withdrawal of the stimulus implicated several widespread human diseases through ill-defined vivo mechanisms....
Abstract In order to study the role of maternal NKT cells against a Chlamydia infection during pregnancy, we have compared CD1d-deficient, C57Bl/6 (B6) mice wild type controls, in presence or absence infection. We examined expression several molecules known be important for cell function, uterus and placenta. focused our on NKG2A, NKG2C NKG2D receptors, their ligands Qa-1 Rae-1 co-receptors CD94, DAP10 DAP12. also studied perforin, granzyme B, osteopontin cytokines such as TNF alpha,...
Abstract Cytotoxic CD8+ T cells are paramount for effective cancer immunotherapy. We engineered two distantly related arenaviruses, lymphocytic choriomeningitis virus (LCMV) and Pichinde (PICV), encoding the same non-oncogenic HPV16 E7E6 fusion protein to effectively mount maintain tumor specific cell responses. The designated vectors, HB-201 HB-202 currently in an ongoing Phase I/II open labelled clinical trial of single vector therapy HB-202/HB-201 alternating two-vector patients with...
Abstract T cells play a central role in immune responses against cancer. Within the tumor, however, are exposed to plethora of inactivating factors causing various degrees dysfunction, changes metabolism and generally reduced cellular fitness, eventually leading tumor progression. To prevent or delay onset exhaustion instead augment effector functions persistence functional cells, costimulatory cytokines needed. Targeting 4-1BB (CD137), member necrosis factor receptor superfamily, has been...