A5082181496- Cystic Fibrosis Research Advances
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- Nutrition and Health in Aging
- Tracheal and airway disorders
- Long-Term Effects of COVID-19
- Adolescent and Pediatric Healthcare
- Antifungal resistance and susceptibility
- COVID-19 and Mental Health
- Diabetes Management and Research
- Bone health and osteoporosis research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sinusitis and nasal conditions
- Immunodeficiency and Autoimmune Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Breastfeeding Practices and Influences
- Folate and B Vitamins Research
- Prenatal Screening and Diagnostics
- Respiratory viral infections research
- Antibiotic Resistance in Bacteria
- Asthma and respiratory diseases
- Delphi Technique in Research
- Pregnancy and Medication Impact
- Nematode management and characterization studies
Cardiff and Vale University Health Board
2015-2025
University Hospital Llandough
2015-2025
Cystic Fibrosis Trust
2023-2024
University Hospital of Wales
2021-2023
Public Health Wales
2023
National Health Service Wales
2021-2022
Barts Health NHS Trust
2021
University of Limerick
2020
Nottingham University Hospitals NHS Trust
2020
Bambino Gesù Children's Hospital
2019
Background Many people recovering from coronavirus disease 2019 (COVID-19) experience prolonged symptoms, particularly breathlessness. We urgently need to identify safe and effective COVID-19 rehabilitative strategies. The aim of the current study was investigate potential role inspiratory muscle training (IMT). Methods 281 adults (age 46.6±12.2 years; 88% female) self-reported (9.0±4.2 months post-acute infection) were randomised 4:1 an 8-week IMT or a “usual care” waitlist control arm....
Bronchiectasis is a chronic inflammatory lung disease, which has similarities to obstructive pulmonary disease (COPD). Comorbidities of COPD include increased risk cardiovascular (CV) loss bone mineral density (BMD) and skeletal muscle mass function, all linked systemic inflammation. The potential for such comorbidities not been explored in bronchiectasis. We hypothesised that patients with bronchiectasis would have similar comorbidities. A total 20 noncystic fibrosis were compared controls...
Understanding of strategies to support individuals recovering from coronavirus disease 2019 (COVID-19) is limited. 'Long COVID' a multisystem characterised by range respiratory, gastrointestinal, cardiovascular, neurological, and musculoskeletal symptoms extending beyond 12 weeks. The aim this study was explore individuals' experiences COVID-19 provide better understanding the acute long-term impact on physical activity (PA). Individualised semi-structured interviews were conducted with 48...
Background Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterized by dysfunction of motile cilia. Symptoms include recurrent and chronic airway infections which can lead to deteriorating lung function inflammatory destructive disease in the form persistent atelectasis bronchiectasis. Routine blood testing may be used as tool for monitoring management. However, currently there are no consensus-based guidelines within field PCD. BEAT-PCD together with ERN-LUNG PCD-Clinical...
Background A person’s beliefs about treatment influence their engagement and adherence to that treatment. The Necessity-Concerns Framework suggests is influenced by a judgement of own need for (necessity beliefs) concerns the potential adverse consequences taking This study was conducted explore elexacaftor-tezacaftor-ivacaftor (ETI) therapy (Kaftrio) in adults with cystic fibrosis (CF). Methods total 64 CF were maintained on ETI as part routine care, completed Beliefs Medicines...
Deeper understanding of mold-induced cytokine signatures could promote advances in the diagnosis and treatment invasive mycoses mold-associated hypersensitivity syndromes. Currently, most T-cellular immunoassays medical mycology require isolation mononuclear cells have limited robustness practicability, hampering their broader applicability clinical practice. Therefore, we developed a simple, cost-efficient whole blood (WB) assay with dual α-CD28 α-CD49d co-stimulation to quantify secretion...
To compare pregnancy rates and outcomes for women with cystic fibrosis in the UK those of general population assess effect introduction disease-modifying treatment.A population-based longitudinal study, 2003-17.United Kingdom.Women aged 15-44 years (CF) Registry compared England Wales.We calculated live-birth CF Wales. For we before after ivacaftor was introduced 2013. We further used registry data to mothers CF, relationship between maternal pre-pregnancy lung function nutritional status...
Cystic fibrosis (CF) limits survival and negatively affects health-related quality of life (HRQOL). Cost-effectiveness analysis (CEA) may be used to make reimbursement decisions for new CF treatments; nevertheless, generic utility measures in CEA, such as EQ-5D, are insensitive meaningful changes lung function HRQOL CF. Here we develop a new, disease-specific, preference-based measure based on the adolescent/adult version Fibrosis Questionnaire-Revised (CFQ-R), widely used, CF-specific,...
Background: therapeutic drug monitoring is a crucial aspect of the management hospitalized patients. The correct dosage antibiotics imperative to ensure their adequate exposure specially in critically ill aim this study establish and validate robust fast liquid chromatography-tandem mass spectrometry (LC/MS) method for simultaneous quantification two important patients, cefiderocol meropenem human plasma. Methods: sample clean-up was performed by protein precipitation using acetonitrile....
In cystic fibrosis (CF) patients, Gram-negative Burkholderia cepacia complex (Bcc) infections are associated with recurrent pulmonary exacerbations. Bcc organisms innately resistant to many antibiotics, and infection B. cenocepacia is a contraindication lung transplantation. We report CF patient severe disease, colonized Bcc, history of around nine exacerbations per year for over 10 years, whom antibiotic regimens (including targeted broad-spectrum antibiotics) had not cleared or extended...
Abstract Background Current guidelines for the management of bronchiectasis (BE) highlight lack evidence to recommend mucoactive agents, such as hypertonic saline (HTS) and carbocisteine, aid sputum removal part standard care. We hypothesise that agents (HTS or a combination) are effective in reducing exacerbations over 52-week period, compared usual Methods This is 52-week, 2 × factorial, randomized, open-label trial determine clinical effectiveness cost HTS 6% carbocisteine airway...
There are complex medical, psychological, social and economic aspects to becoming a parent with Cystic Fibrosis (CF). A shared decision-making (SDM) approach could help women CF make informed decisions about their reproductive goals that sensitive individual values preferences. This study investigated capability, opportunity, motivation participate in SDM from the perspective of CF.
Abstract Aims To examine HbA 1c as a predictor of risk for future development cystic fibrosis‐related diabetes and to assess the association with retinopathy in people diabetes. Methods A 7‐year retrospective longitudinal study was conducted 50 adults fibrosis, comparing oral glucose tolerance test results values predicting Retinal screening data were also compared measurements microvascular outcome. Results An value ≥37 mmol/mol (5.5%; hazard ratio 3.49, CI 1.5–8.1) significantly associated...
Cystic fibrosis (CF) is a common autosomal recessive disorder in Caucasian populations with respiratory, gastrointestinal and endocrine manifestations. Thanks to recent advances medical therapies infection control, life expectancy of patient CF has significantly increased from less than 5 years the mid-1900s almost 50 nowadays. However, as patients are living longer, multimorbidity Hyperpharmacotherapy becoming more common. This case illustrates cascade problems that ensued medication...