A5075092345- Cystic Fibrosis Research Advances
- Asthma and respiratory diseases
- Respiratory viral infections research
- Antimicrobial Resistance in Staphylococcus
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Advanced biosensing and bioanalysis techniques
- Pneumonia and Respiratory Infections
- Advanced Breast Cancer Therapies
- Pneumocystis jirovecii pneumonia detection and treatment
- Inhalation and Respiratory Drug Delivery
- Family and Patient Care in Intensive Care Units
- Vasculitis and related conditions
- Antifungal resistance and susceptibility
- Immune Response and Inflammation
- Nutrition and Health in Aging
- Immune Cell Function and Interaction
- Bacteriophages and microbial interactions
- Transplantation: Methods and Outcomes
- Healthcare Policy and Management
- Bacterial biofilms and quorum sensing
- Sarcoidosis and Beryllium Toxicity Research
Dell Children's Medical Center of Central Texas
2021-2025
Cystic Fibrosis Foundation
2025
Seton Medical Center Austin
2025
Seton Healthcare Family
2019-2020
Baylor College of Medicine
2005
Pulmonary Associates
2005
The University of Texas Health Science Center at Houston
2002
Background: Among people with cystic fibrosis (PwCF), methicillin-resistant Staphylococcus aureus (MRSA)-associated acute pulmonary exacerbations (APEs) have been increasing in prevalence and can cause rapid declines lung function increased mortality. Fortunately, since 2019, incidence has started to decline. Objective: The purpose of this study was evaluate if doxycycline comparable efficacy vancomycin for the treatment APEs PwCF. Given potential toxicities intolerances associated...
Bronchiolitis obliterans (BO) in children is a rare, inflammatory/fibrosing process involving the small airways that often results progressive, irreversible obstructive pulmonary disease. Because treatment has focused mainly on supportive care and generally unsuccessful immunosuppression, with BO experience significant morbidity mortality. We report case of biopsy-proven after bone marrow transplantation child who, failed corticosteroid therapy, was treated infliximab, monoclonal antibody...
Cystic fibrosis (CF) programs and people with CF (PwCF) employed various monitoring methods for virtual care during the COVID-19 pandemic. This paper characterizes experiences remote across U.S. community.The Foundation (CFF) sponsored distribution of home spirometers (April 2020 to May 2021), surveys PwCF (July September 2020), a second program survey 2021). We used mixed explore access, use, perspectives regarding use in future care.By October 2020, 13,345 had been distributed, 19,271 by...
Viral respiratory infections play an important role in the development and progression of pulmonary disease cystic fibrosis (CF). The CF mouse model provides a tool to examine relationship between transmembrane conductance regulator (CFTR) defect lung disease. This work investigates cellular response common viral pathogen, syncytial virus (RSV) mice. RSV was administered by intranasal inoculation CFTRtm1Unc-Tg(FABPCFTR)1Jaw/J (CFTR−/−) control At day 5 post infection, titers, bronchoalveolar...
Cysteinyl leukotrienes (CysLTs) contribute to the development of airway obstruction and inflammation in asthma; however little information is available on role these molecules pathophysiology respiratory syncytial virus (RSV) bronchiolitis. This study was designed evaluate effects RSV infection CysLTs production a well-established mouse model. Furthermore, we assessed effect anti-inflammatory agents (a leukotriene receptor antagonist, MK-571, dexamethasone) functional immune changes induced...
Abstract Exposure to endotoxin has been associated with an exacerbation of asthmatic responses in humans and animal models. However, recent evidence suggests that microbial exposure early life may protect from the development asthma atopy. In this study, we sought evaluate effects lipopolysaccaride (LPS) on airway function developing mice. addition, evaluated influence LPS subsequent allergen sensitization challenge. Under light anesthesia, 2–3‐week‐old Balb/c mice received a single...
Abstract Drugs and drug delivery systems have to traverse multiple biological barriers achieve therapeutic efficacy. In diseases of mucosal-associated tissues such as cystic fibrosis (CF), successful gene therapies remains a significant challenge due an abnormally concentrated viscoelastic mucus, which prevents ~99% all drugs particles from penetrating the mucus barrier underlying epithelia for effective therapy, resulting in decreased survival. We used combinatorial peptide-presenting phage...
Background: Among patients with cystic fibrosis (CF), methicillin-resistant Staphylococcus aureus (MRSA)-associated acute pulmonary exacerbations (APEs) are increasing in prevalence and can cause rapid declines lung function mortality. Limited data exist on the preferred treatment of MRSA-associated APEs, vancomycin often considered first-line. Given potential toxicities intolerances associated vancomycin, evaluating alternative therapies such as doxycycline is warranted. Methods: This...