A5021391022- Bone health and treatments
- Biomarkers in Disease Mechanisms
- Cancer Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
- Bone Metabolism and Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- MicroRNA in disease regulation
- Medical Imaging Techniques and Applications
- Cytokine Signaling Pathways and Interactions
- Body Composition Measurement Techniques
- Mesenchymal stem cell research
- Consumer Retail Behavior Studies
- COVID-19 Pandemic Impacts
- Consumer Behavior in Brand Consumption and Identification
- Multiple Myeloma Research and Treatments
- Nutrition and Health in Aging
- Healthcare Systems and Reforms
- Sports injuries and prevention
- Organizational Leadership and Management Strategies
- Organizational and Employee Performance
- Bone health and osteoporosis research
- Single-cell and spatial transcriptomics
- Circular RNAs in diseases
- COVID-19 epidemiological studies
- Innovation and Socioeconomic Development
University of Arkansas for Medical Sciences
2024-2025
Winthrop Rockefeller Foundation
2024
Mayo Clinic in Arizona
2020-2023
Mayo Clinic in Florida
2023
Regional Cancer Center, Thiruvananthapuram
2023
Mayo Clinic
2020-2023
WinnMed
2020-2023
Johns Hopkins University
2020-2022
Panjab University
2014-2021
University of Oklahoma
2018-2020
Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles SnCs in mediating tissue dysfunction remain unclear. Thus, we developed a mouse model (p16-LOX-ATTAC) that allowed for inducible SnC elimination (senolysis) cell-specific manner and compared effects senolysis during aging using as prototype tissue. Specific removal Sn osteocytes prevented loss at spine, but not femur, by improving formation without...
Senescence drives organismal aging, yet the deep characterization of senescent cells in vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully validated antibodies to analyze at single-cell resolution. We use multiple criteria identify mesenchymal that are growth-arrested and resistant apoptosis. These p16 + Ki67-BCL-2+ highly enriched for senescence-associated secretory phenotype DNA damage markers, strongly associated with age, their percentages increased...
Aging | doi:10.18632/aging.204701. Parinya Samakkarnthai, Dominik Saul, Lei Zhang, Zaira Aversa, Madison L. Doolittle, Jad G. Sfeir, Japneet Kaur, Elizabeth J. Atkinson, James R. Edwards, Graham Russell, Robert Pignolo, Kirkland, Tamar Tchkonia, Laura Niedernhofer, David Monroe, Nathan K. Lebrasseur, Joshua N. Farr, Paul D. Robbins, Sundeep Khosla
Breast cancer bone metastases increase fracture risk and are a major cause of morbidity mortality among women. Upon colonization by tumor cells, the microenvironment undergoes profound reprogramming to support progression, which disrupts balance between osteoclasts osteoblasts leads lesions. A deeper understanding processes mediating this could help develop interventions for treating patients with metastases. Here, we demonstrated that osteocytes (Ot) in established breast metastasis...
Multiple myeloma (MM) remains incurable due to disease relapse and drug resistance. Notch signals from the tumor microenvironment (TME) confer chemoresistance, but cellular molecular mechanisms are not entirely understood. Using clinical transcriptomic datasets, we found that NOTCH3 is upregulated in CD138+ cells newly diagnosed MM (NDMM) patients compared healthy individuals increased progression/relapsed (PRMM) patients. Further, NDMM with high expression exhibited worse responses...
Internal marketing has been an area of interest for the past few decades, and rapid growth on internal literature evolved concept further. However, this theoretical advancement not able to empirically strengthen concept, there exists disagreement key components marketing. Thus, article endeavours identify dimensions by probing in extant literature. In addition, aim was develop a robust valid instrument measuring Data were collected from qualitative study 154 employees financial service...
Abstract Multiple myeloma (MM) remains incurable due to disease relapses, thought stem from the activation of dormant MM cells. Preventing awakening or eliminating cells is crucial avoiding relapse. In this study, we sought identify targetable vulnerabilities eliminate control First, used a scRNAseq dataset and found that exhibit upregulation Notch pathway genes compared proliferating Based on this, hypothesized inhibiting signals in tumor niche should decrease To test notion, injected...
Multiple myeloma (MM) is a clonal plasma cell proliferative malignancy characterized by debilitating bone disease. Osteolytic destruction, hallmark of MM, driven increased osteoclast number and exacerbated resorption, primarily fueled the excessive production RANKL, master regulator formation, within tumor niche. We previously reported that osteocytes, most abundant cells in niche, promote progression support MM disease overproducing RANKL. However, molecular mechanisms underlying RANKL...
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