A5030592903- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacterial Infections and Vaccines
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Influenza Virus Research Studies
- Respiratory Support and Mechanisms
- SARS-CoV-2 detection and testing
- COVID-19 and healthcare impacts
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- Asthma and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Antimicrobial Resistance in Staphylococcus
- COVID-19 and Mental Health
- Vaccine Coverage and Hesitancy
- Respiratory and Cough-Related Research
- Child and Adolescent Health
- Streptococcal Infections and Treatments
- Cystic Fibrosis Research Advances
- COVID-19 Impact on Reproduction
Zealand University Hospital
2015-2025
Copenhagen University Hospital
2014-2025
University of Copenhagen
2010-2025
Statens Serum Institut
2015-2025
Nordsjællands Hospital
2018-2024
Rigshospitalet
2005-2024
Roskilde University
2024
European Society of Clinical Microbiology and Infectious Diseases
2020-2023
Gentofte Hospital
2021
Taronga Conservation Society Australia
2016
Abstract Due to urgency and demand, numerous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoassays are rapidly being developed placed on the market with limited validation clinical samples. Thorough of serological tests required facilitate their use in accurate diagnosis SARS-CoV-2 infection, confirmation molecular results, contact tracing, epidemiological studies. This study evaluated sensitivity specificity nine commercially available tests. These included three...
Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim this study was to investigate the association between specific pneumococcal serotypes from invasive (IPD).In nationwide population-based cohort IPD in Denmark during 1977-2007, 30-d associated with examined by multivariate logistic regression analysis after controlling for potential confounders. A total 18,858 patients were included. Overall 18%, 3% children younger than age 5 y. Age, male sex, meningitis,...
Background. The impact of the 13-valent pneumococcal conjugate vaccine (PCV13) at population level is unclear. We explored PCV13's effect in reducing invasive disease (IPD)–related morbidity and mortality, whether serotype-specific changes were attributable to vaccination or expected as a part natural, cyclical variations.
Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host pathogen known to play role in pneumococcal disease, though what extent unknown. In genome-wide association study human we show that explains almost half susceptibility meningitis one-third severity, identifying variants CCDC33 associated with susceptibility. Pneumococcal genetic large amount potential...
There are limited data on outcomes of moderate to severe coronavirus disease 2019 (COVID-19) among patients treated with remdesivir and dexamethasone in a real-world setting. We sought compare the effectiveness standard care (SOC) alone versus SOC plus dexamethasone.Two population-based nationwide cohorts individuals hospitalized COVID-19 during February through December 2020 were studied. Death within 30 days need mechanical ventilation (MV) compared by inverse probability treatment...
Previous studies have indicated inferior responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination in solid organ transplant (SOT) recipients. We examined the development of anti-receptor-binding domain (RBD) immunoglobulin G (IgG) after two doses BNT162b2b SOT recipients 6 months and compared that immunocompetent controls.
Persons infected with human immunodeficiency virus (HIV) are often hyporesponsive to immunization, including pneumococcal vaccines. We hypothesized that adding CPG 7909, a toll-like receptor 9 (TLR9) agonist and vaccine adjuvant, 7-valent conjugate (7vPnC) would increase its immunogenicity in HIV-infected adults.We performed double-blind, placebo-controlled, phase 1b/2a trial randomizing HIV-positive patients receive double doses of 7vPnC (Prevnar) at 0 3 months 1 dose 23-valent...
The search to identify disease-susceptible genes requires access biological material from numerous well-characterized subjects. Archived residual dried blood spot (DBS) samples, also known as Guthrie cards, national newborn screening programs may provide a DNA source for entire populations. Combined with clinical information medical registries, DBS samples could rich productive research. However, the amounts of which can be extracted these precious are minute and prohibitive genotypings....
Abstract Background Venous thromboembolism (VTE) is a potentially fatal complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and thromboprophylaxis should be balanced against risk bleeding. This study examined risks VTE major bleeding in hospitalized community-managed SARS-CoV-2 patients compared with control populations. Methods Using nationwide population-based registries, 30-day positive were those test-negative an external cohort influenza patients....
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has been associated with a high risk of adverse outcomes in solid organ transplant (SOT) recipients the pre-vaccination era. In this retrospective cohort study, we examined incidence and severity COVID-19 kidney liver Denmark post-vaccination era, from December 27, 2020, to 2021. We included 1428 SOT 143 cases first-positive PCR test. The cumulative test 1 year after initiation vaccination was 10.4% (95% CI: 8.8-12.0), higher than...
The measurement of IgG anti-pertussis toxin (IgG anti-PT) antibodies by ELISA is a frequently used method for studying the antibody responses after pertussis vaccination and Bordetella infection. Such vary according to different vaccines as well immunization infection history participants. In present study, decay kinetics anti-PT response was determined 71 Danish children adults with bacteriologically confirmed B. 20 booster-vaccinated an acellular vaccine. For both groups, biphasic seen,...
Since 2010, Denmark has included the 13-valent pneumococcal conjugated vaccine (PCV-13) in childhood immunization programme. However, serotype 3 remains as an important cause of invasive disease (IPD) Denmark. IPD surveillance data (1999–2016) was used to calculate incidence and age-distribution IPD, effect PCV-13 on examined. The age group below 65 years 0.51/100,000 pre PCV-13, 0.45/100,000 post PCV-13. In 0–4 years, 0.28/100,000 0.16/100,000 Serotype elderly showed a mean 4.27/100,000...
Recently, reports of severe thromboses, thrombocytopenia, and hemorrhage in persons vaccinated with the chimpanzee adenovirus-vectored vaccine (ChAdOx1 nCoV-19, AZD1222, Vaxzevria; Oxford/AstraZeneca) against acute respiratory syndrome coronavirus 2 have emerged. We describe an otherwise healthy 30-year-old woman who developed ecchymosis, portal vein thrombosis, cerebral venous sinus thrombosis second week after she received ChAdOx1 nCoV-19 vaccine. Extensive diagnostic workup for...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated disease 2019 (COVID-19), is a worldwide emergency. Demographic, comorbidity laboratory determinants of death ICU admission were explored in all Danish hospitalised patients.National health registries used to identify hospitalized patients with COVID-19 diagnosis. We obtained demographics, Charlson Comorbidity Index (CCI), results on prognostic factors for using multivariate Cox proportional hazard regression...
Background: Estimates of the severity emerging Omicron variant (lineage B.1.1.529) are critical to assess public health impact associated with its rapid global dissemination. We estimated risk SARS-CoV-2-related hospitalizations after infection compared Delta overall and stratified by vaccination status in Denmark, a country high mRNA coverage an extensive free-of-charge PCR test capacity.Methods: Observational cohort study all RT-PCR SARS-CoV-2 positive individuals Denmark between 21...
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Background/Objectives: Influenza and Streptococcus pneumoniae infections are common vaccine-preventable diseases to which people living with HIV (PLWH) may be more susceptible. This study aims investigate the incidence of confirmed influenza pneumococcal infections, determine rate (IR) factors associated vaccine uptake in a population virologically suppressed PLWH. Methods: We included 1031 PLWH from Copenhagen Comorbidity Infection (COCOMO) study. Data on vaccinations between 2015 2020 were...