A5085119530- Platelet Disorders and Treatments
- Glycosylation and Glycoproteins Research
- Blood groups and transfusion
- Hematopoietic Stem Cell Transplantation
- Carbohydrate Chemistry and Synthesis
- Acute Myeloid Leukemia Research
- Complement system in diseases
- Monoclonal and Polyclonal Antibodies Research
- Blood disorders and treatments
- Alcohol Consumption and Health Effects
- Acute Lymphoblastic Leukemia research
- Child Nutrition and Water Access
- Viral Infectious Diseases and Gene Expression in Insects
- Protein purification and stability
- Fungal Infections and Studies
- Lung Cancer Treatments and Mutations
- Vitamin K Research Studies
- Breastfeeding Practices and Influences
- Blood Coagulation and Thrombosis Mechanisms
- Cutaneous lymphoproliferative disorders research
- Connective tissue disorders research
- Blood transfusion and management
- Multiple Myeloma Research and Treatments
- Intramuscular injections and effects
- Parathyroid Disorders and Treatments
Copenhagen University Hospital
2021-2024
Rigshospitalet
2021-2024
University of Copenhagen
2005-2022
Brigham and Women's Hospital
2005-2012
Harvard University
2007-2012
ProQuest (United States)
2005-2007
The MUC1 mucin represents a prime target antigen for cancer immunotherapy because it is abundantly expressed and aberrantly glycosylated in carcinomas. Attempts to generate strong humoral immunity by immunization with peptides have generally failed partly of tolerance. In this study, we developed chemoenzymatic synthesis extended TR glycopeptides cancer-associated O-glycosylation using panel recombinant human glycosyltransferases. different densities Tn STn glycoforms conjugated KLH were...
The cell membrane mucin MUC1 is over-expressed and aberrantly glycosylated in many cancers, cancer-associated glycoforms represent potential targets for immunodiagnostic therapeutic measures. We have recently shown that with GalNAcα1-O-Ser/Thr (Tn) NeuAcα2-6GalNAcα1-O-Ser/Thr (STn) O-glycosylation a cancer-specific glycoform, Tn/STn-MUC1 glycopeptide-based vaccines can override tolerance human transgenic mice induce humoral immunity high specificity (Sorensen AL, Reis CA, Tarp MA, Mandel U,...
Recently, reports of severe thromboses, thrombocytopenia, and hemorrhage in persons vaccinated with the chimpanzee adenovirus-vectored vaccine (ChAdOx1 nCoV-19, AZD1222, Vaxzevria; Oxford/AstraZeneca) against acute respiratory syndrome coronavirus 2 have emerged. We describe an otherwise healthy 30-year-old woman who developed ecchymosis, portal vein thrombosis, cerebral venous sinus thrombosis second week after she received ChAdOx1 nCoV-19 vaccine. Extensive diagnostic workup for...
Abstract Background The treatment of relapsed or refractory (R/R) acute myeloid leukaemia (AML) remains challenging and outcomes extremely poor. introduction venetoclax has transformed the AML emerging data suggest that venetoclax‐based therapy may enforce salvage treatment. Materials Methods In this nationwide Danish retrospective study, we analysed for R/R between 2019 2022. Only venetoclax‐naive patients who had previously received with intensive chemotherapy were included. Results cohort...
Transfusion therapy is a critical part of supportive care early after allogeneic hematopoietic cell transplantation (allo-HCT). Platelet and RBC transfusions elicit immunomodulatory effects in the recipient, but if this impacts risk acute graft-versus-host disease (aGVHD) has only been scarcely investigated. We investigated platelet were associated with development aGVHD following myeloablative allo-HCT cohort 664 patients who underwent between 2000 2019. Data further analyzed for impact...
Bleeding disorder of unknown cause (BDUC) is a challenging diagnosis that predominantly affects women. Previous investigations into connective tissue disorders (CTD) and vitamin C have not been conducted.
Abstract Background The present case contributes to the limited literature on central nervous system involvement of blastic plasmacytoid dendritic cell neoplasm (BPDCN). Case presentation A 63-year-old male presented department neurology with a three-day history rapidly progressing headache, fatigue, and confusion. Physical examination revealed multiple bruise-like skin lesions. Initial laboratory workup raised suspicion acute leukemia, brain computer tomography identified several hyperdense...
<h3>Background and aims</h3> Preterm birth predisposes to neurological sequelae. Necrotizing enterocolitis (NEC) may further increase the susceptibility damage, possibly via gut-derived inflammatory signals. To investigate this, we test if NEC severity intestinal permeability in formula-fed preterm pigs is associated with histopathology, microglial activation, increased proinflammatory cytokine levels hippocampus. <h3>Methods</h3> Forty-four piglets were fed increasing doses of formula...