Kamille Fogh
A5079979177- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Infection Control and Ventilation
- Immunotherapy and Immune Responses
- Vaccine Coverage and Hesitancy
- Respiratory viral infections research
- Homelessness and Social Issues
- Animal Virus Infections Studies
- COVID-19 Impact on Reproduction
- Peripheral Neuropathies and Disorders
- HIV, Drug Use, Sexual Risk
- Retinal and Optic Conditions
- Historical Medical Research and Treatments
- Shoulder Injury and Treatment
- Cancer Immunotherapy and Biomarkers
- Biosensors and Analytical Detection
- MRI in cancer diagnosis
- Inflammasome and immune disorders
- Hepatitis B Virus Studies
- Influenza Virus Research Studies
- Head and Neck Surgical Oncology
Gentofte Hospital
2020-2024
Herlev Hospital
2004-2024
Copenhagen University Hospital
2004-2024
University of Copenhagen
2012-2023
Statens Serum Institut
2023
Aarhus University Hospital
2023
Aarhus University
2023
Zealand University Hospital
2022
Copenhagen Municipal Hospital
2013
Health-care workers are thought to be highly exposed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed investigate the prevalence of antibodies against SARS-CoV-2 in health-care and proportion seroconverted with previous symptoms COVID-19.In this observational cohort study, screening was offered Capital Region Denmark, including medical, nursing, other students who were associated hospitals region. Screening included point-of-care tests for IgM IgG SARS-CoV-2....
Observational evidence suggests that mask wearing mitigates transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is uncertain if this observed association arises through protection uninfected wearers (protective effect), via reduced from infected (source control), or both.
Abstract SARS-CoV-2 vaccines are crucial in controlling COVID-19, but knowledge of which factors determine waning immunity is limited. We examined antibody levels and T-cell gamma-interferon release after two doses BNT162b2 vaccine or a combination ChAdOx1-nCoV19 for up to 230 days the first dose. Generalized mixed models with without natural cubic splines were used over time. Antibody responses influenced by infection, sex, age. IgA only became significant naturally infected. A one-year IgG...
Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are needed to support clinical diagnosis and epidemiological investigations. Recently, large-scale detection of total antibodies (Ab), immunoglobulin G (IgG), IgM against SARS-CoV-2 antigens have been developed, but there limited data on the diagnostic accuracy these assays. This study was a Danish national collaboration evaluated 15 commercial one in-house anti-SARS-CoV-2 in 16 laboratories. Sensitivity...
SARS-CoV-2 variants of concern have continuously evolved and may erode vaccine induced immunity. In this observational cohort study, we determine the risk breakthrough infection in a fully vaccinated cohort. anti-spike IgG levels were measured before first vaccination at day 21-28, 90 180, as well after booster vaccination. Breakthrough infections captured through Danish National Microbiology database. incidence rate ratio (IRR) for time-updated was determined using Poisson regression. Among...
To identify individual characteristics associated with serological COVID-19 vaccine responsiveness and the durability of vaccine-induced antibodies.Adults without history SARS-CoV-2 infection from Danish population scheduled for vaccination were enrolled in this parallel group, phase 4 study. Spike IgG Spike-ACE2-receptor-blocking antibodies measured at days 0, 21, 90, 180. Vaccine was categorized according to levels day 90 after first vaccination. Nondurable response defined as day-90...
Previous studies have indicated inferior responses to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccination in solid organ transplant (SOT) recipients. We examined the development of anti-receptor-binding domain (RBD) immunoglobulin G (IgG) after two doses BNT162b2b SOT recipients 6 months and compared that immunocompetent controls.
Older age and chronic disease are important risk factors for developing severe COVID-19. At population level, vaccine-induced immunity substantially reduces the of COVID-19 hospitalization. However, relative impact humoral cellular on protection from breakthrough infection is not fully understood.In a study cohort 655 primarily older participants (median 63 years (IQR: 51-72)), we determined serum levels Spike IgG antibodies using Multiantigen Serological Assay quantified frequency...
We investigated long-term durability of humoral and cellular immune responses to third dose BNT162b2 in people with HIV (PWH) controls.In 378 PWH undetectable viral replication 224 matched controls vaccinated three doses BNT162b2, we measured IgG-antibodies against the receptor binding domain SARS-CoV-2 spike protein months before four eleven after. In 178 135 controls, response was assessed by interferon-γ (IFN-γ) release whole blood after dose. Differences antibody or IFN-γ concentrations...
Abstract Background People with HIV (PWH) are at increased risk of severe COVID‐19. We aimed to determine humoral responses in PWH and controls who received two doses BNT162b2. Methods In 269 538 age‐matched controls, we measured IgG neutralizing antibodies specific for the receptor‐binding domain SARS‐CoV‐2 baseline, 3 weeks 2 months after first dose Results from baseline both groups, but concentrations were lower than that ( p = 0.025 <0.001), respectively. The titres a response 77.9%...
Abstract Background People experiencing homelessness (PEH) and associated shelter workers may be at higher risk of infection with “Severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2). The aim this study was to determine the prevalence SARS-CoV-2 among PEH in Denmark. Design methods In November 2020, we conducted a nationwide cross-sectional seroprevalence 21 recruitment sites assessment included point-of-care test for antibodies against SARS-CoV-2, followed by questionnaire....
Introduction We investigated humoral and T-cell responses within 12 months after first BNT162b2 vaccine in solid organ transplant (SOT) recipients controls who had received at least three doses. Furthermore, we compared the immune response participants with without previous SARS-CoV-2 infection. Methods included adult liver, lung, kidney recipients, were selected from a parallel cohort of healthcare workers. Results At 12th-month, IgG geometric mean concentrations (GMCs) (P&lt;0.001),...
COVID-19 is thought to be more prevalent among ethnic minorities and individuals with low socioeconomic status. We aimed investigate the prevalence of SARS-CoV-2 antibodies during pandemic citizens 15 years or older in Denmark living social housing (SH) areas.
Introduction Responses to COVID-19 vaccination in patients with chronic pulmonary diseases are poorly characterised. We aimed describe humoral responses following two doses of BNT162b2 mRNA vaccine and identify risk factors for impaired responses. Methods Prospective cohort study including adults healthcare personnel as controls (1:1). Blood was sampled at inclusion, 3 weeks, 2 6 months after first vaccination. reported antibody concentrations geometric means 95% CI receptor binding domain...
Dear Editor, We report data on the antibody response against SARS-CoV-2 receptor-binding domain (RBD) in healthcare professionals from two hospitals Copenhagen at baseline and 3 weeks post first injection with BNT162b2 mRNA COVID-19 vaccine. The was assessed using assays measuring neutralizing capacity (NAbs) [1] direct binding of IgG, IgM IgA [2]. Moreover, we tested responses nucleocapsid (N) protein, which is not a part vaccine used as proxy for natural infection. For more details, see...
This cohort study included questionnaire data as well anti-nucleocapsid antibody analysis, allowing us to determine whether participants were seropositive due vaccination or natural infection. The emphasizes the importance of early confirmation COVID-19, antibodies recede with time, and it indicates an overlap between long COVID symptoms possibly another origin.
Abstract Serological SARS-CoV-2 assays are needed to support clinical diagnosis and epidemiological investigations. Recently, for the large-volume detection of total antibodies (Ab) immunoglobulin (Ig) G M against antigens have been developed, but there limited data on diagnostic accuracy these assays. This study was organized as a Danish national collaboration included fifteencommercial one in-house anti-SARS-CoV-2 in sixteen laboratories. Sensitivity evaluated using 150 serum samples from...
Abstract Background Health care workers are at a higher risk of getting infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than the general population. Knowledge about medical students’ exposure to SARS-CoV-2 is lacking. Thus, we measured prevalence antibodies in cohort Danish students. Methods We invited all students University Copenhagen (UCPH) participate. Students underwent venous blood sampling and questionnaire work-life behaviors possibly associated disease...
"Testing Denmark" is a national, large-scale, epidemiological surveillance study of SARS-CoV-2 in the Danish population. Between September and October 2020, approximately 1.3 million people (age >15 years) were randomly invited to fill an electronic questionnaire covering COVID-19 exposures symptoms. The prevalence antibodies was determined by point-of care rapid test (POCT) distributed participants' home addresses. In total, 318,552 participants (24.5% invitees) completed 2,519 (0.79%)...
SARS-CoV-2 Omicron quickly spread globally, also in regions with high vaccination coverage, emphasizing the importance of exploring immunological requirements for protection against breakthrough infection. The test-negative matched case-control study (N = 964) characterized infections triple-vaccinated individuals from ENFORCE cohort. Within 60 days before a PCR test spike-specific IgG levels were significantly lower cases compared to controls (GMR [95% CI] BA.2: 0.83 [0.73-0.95], p 0.006)....
Knowledge about the effect of vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on immunity reflected in saliva is sparse. We examined antibody response compared to that serum and 6 months after first with BNT162b2 vaccine. Four hundred fifty-nine health care professionals were included a prospective observational study measuring levels corresponding samples at vaccination. Vaccinated, previously SARS-CoV-2-infected individuals (hybrid immunity) had higher IgG...
Abstract Background People experiencing homelessness (PEH) and associated shelter workers may be at higher risk of infection with “Severe acute respiratory syndrome coronavirus 2” (SARS-CoV-2). The aim this study was to determine the prevalence SARS-CoV-2 among PEH in Denmark. Design methods In November 2020, we conducted a nationwide cross-sectional seroprevalence 21 recruitment sites assessment included point-of-care test for antibodies against SARS-CoV-2, followed by questionnaire....
Most individuals seroconvert after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but being seronegative is observed in 1 to 9%. We aimed investigate the risk factors associated following PCR-confirmed SARS-CoV-2 infection. In a prospective cohort study, we screened health care workers (HCW) Capital Region of Denmark for antibodies. performed three rounds screening from April October 2020 using an enzyme-linked immunosorbent assay (ELISA) method targeting total...