Erik Sørensen
A5018114131- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Blood donation and transfusion practices
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Genetic Associations and Epidemiology
- Restless Legs Syndrome Research
- Migraine and Headache Studies
- Parkinson's Disease Mechanisms and Treatments
- Forensic and Genetic Research
- Sleep and Wakefulness Research
- Immunotherapy and Immune Responses
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- Cancer-related gene regulation
- Parasites and Host Interactions
- Blood groups and transfusion
- Parasite Biology and Host Interactions
- Diabetes and associated disorders
- Ethics in Clinical Research
- Pregnancy and preeclampsia studies
- Epigenetics and DNA Methylation
- Metabolism and Genetic Disorders
- Helminth infection and control
- Molecular Biology Techniques and Applications
Copenhagen University Hospital
2016-2025
Rigshospitalet
2016-2025
University of Copenhagen
2003-2024
Aarhus University
2023-2024
Aarhus University Hospital
2012-2024
Statens Serum Institut
2012-2021
QIMR Berghofer Medical Research Institute
1998
Bangkok Hospital
1992
Health-care workers are thought to be highly exposed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed investigate the prevalence of antibodies against SARS-CoV-2 in health-care and proportion seroconverted with previous symptoms COVID-19.In this observational cohort study, screening was offered Capital Region Denmark, including medical, nursing, other students who were associated hospitals region. Screening included point-of-care tests for IgM IgG SARS-CoV-2....
Detailed knowledge of how diversity in the sequence human genome affects phenotypic depends on a comprehensive and reliable characterization both sequences variation. Over past decade, insights into this relationship have been obtained from whole-exome sequencing or whole-genome large cohorts with rich data1,2. Here we describe analysis 150,119 individuals UK Biobank3. This constitutes set high-quality variants, including 585,040,410 single-nucleotide polymorphisms, representing 7.0% all...
Abstract SARS-CoV-2 vaccines are crucial in controlling COVID-19, but knowledge of which factors determine waning immunity is limited. We examined antibody levels and T-cell gamma-interferon release after two doses BNT162b2 vaccine or a combination ChAdOx1-nCoV19 for up to 230 days the first dose. Generalized mixed models with without natural cubic splines were used over time. Antibody responses influenced by infection, sex, age. IgA only became significant naturally infected. A one-year IgG...
Common infectious pathogens have been associated with psychiatric disorders, self-violence and risk-taking behavior. This case-control study reviews register data on 81,912 individuals from the Danish Blood Donor Study to identify who a diagnosis (N = 2591), attempted or committed suicide 655), had traffic accidents 2724). For all cases, controls were frequency matched by age sex, resulting in 11,546 participants. Plasma samples analyzed for immunoglobulin G (IgG) antibodies against...
The pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has tremendous consequences for our societies. Knowledge of the seroprevalence SARS-CoV-2 is needed accurately monitor spread epidemic and calculate infection fatality rate (IFR). These measures may help authorities make informed decisions adjust current societal interventions. objective was perform nationwide real-time surveying among blood donors as a tool estimate previous infections population-based...
Abstract We report a multi-ancestry genome-wide association study on liver cirrhosis and its associated endophenotypes, alanine aminotransferase (ALT) γ-glutamyl transferase. Using data from 12 cohorts, including 18,265 cases with cirrhosis, 1,782,047 controls, up to 1 million individuals function tests validation cohort of 21,689 617,729 we identify validate 14 risk associations for cirrhosis. Many variants are located near genes involved in hepatic lipid metabolism. One these, PNPLA3...
Dietary studies show a relationship between the intake of iron enhancers and inhibitors stores in general population. However, impact dietary factors on blood donors, whose status is affected by donations, incompletely understood.In Danish Blood Donor Study, we assessed effect donation frequency, physiologic factors, lifestyle supplemental ferritin levels. We used multiple linear logistic regression analyses stratified sex menopausal status.Among high-frequency donors (more than nine...
It is well known that obesity complicates the course of several diseases. However, it unknown whether affects risk infection among healthy individuals.We included 37,808 participants from Danish Blood Donor Study, who completed a questionnaire on health-related items. Obesity was defined as body mass index ≥ 30 kg/m(2). Infections were identified by relevant ICD-10 codes in National Patient Register and Anatomical Therapeutic Chemical (ATC) Prescription Register. Multivariable Cox...
To establish a cohort that enables identification of genomic factors influence human health and empower increased blood donor safe transfusions. Human is complex involves several factors, major one being the aspect. The era has resulted in many consortia encompassing large samples sizes, which proven successful for identifying genetic associated with specific traits. However, it remains big challenge to cohorts facilitate studies interaction between environmental life-style as these change...
To explore whether variability in dietary cholesterol and phytosterol absorption impacts the risk of coronary artery disease (CAD) using as instruments sequence variants ABCG5/8 genes, key regulators intestinal sterols.We examined effects on non-high-density lipoprotein (non-HDL) (N up to 610 532) levels = 3039) CAD Iceland, Denmark, UK Biobank (105 490 cases 844 025 controls). We used genetic scores for non-HDL determine confer greater than predicted by their effect cholesterol. identified...
Introduction of the Omicron variant caused a steep rise in SARS-CoV-2 infections despite high vaccination coverage Danish population. We used blood donor serosurveillance to estimate percentage recently infected residents similarly aged background population with no known comorbidity.To detect antibodies induced due recent infection, and not vaccination, we assessed anti-nucleocapsid (anti-N) immunoglobulin G (IgG) samples. Individual level data on RT-PCR results status were available....
Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) ~1 million controls from Northwestern Europe. searched outside the HLA-locus through effect on coding, mRNA expression in several tissues levels plasma proteins (SomaScan) did network analysis (Qiagen). Results found 25 sequence variants overall, 33 2 RA, altogether...
Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report genome-wide association study of back using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 controls) intervertebral disc (IDD) (58,854 922,958 controls). We identify 41 variants at 33 loci. The most significant (OR
The heterogeneity of the SARS-CoV-2 immune responses has become considerably more complex over time and diverse imprinting is observed in vaccinated individuals. Despite vaccination, following emergence Omicron variant, some individuals appear susceptible to primary infections reinfections than others, underscoring need elucidate how are influenced by previous vaccination. IgG, IgA, neutralizing antibodies T-cell 1,325 (955 which were infection-naive) investigated before after three doses...
Abstract Migraine is a complex neurovascular disease with range of severity and symptoms, yet mostly studied as one phenotype in genome-wide association studies (GWAS). Here we combine large GWAS datasets from six European populations to study the main migraine subtypes, aura (MA) without (MO). We identified four new MA-associated variants (in PRRT2 , PALMD ABO LRRK2 ) classified 13 MO-associated variants. Rare effects highlight three genes. A rare frameshift variant brain-expressed confers...
Abstract Background The emerging use of biomarkers in research and tailored care introduces a need for information about the association between basic demographics lifestyle factors revealing expectable concentrations healthy individuals while considering general demographic differences. Methods A selection 47 biomarkers, including markers inflammation vascular stress, were measured plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined sex, age,...
Abstract Genome-wide association studies (GWASs) may help inform treatments for infertility, whose causes remain unknown in many cases. Here we present GWAS meta-analyses across six cohorts male and female infertility up to 41,200 cases 687,005 controls. We identified 21 genetic risk loci ( P ≤5E-08), of which 12 have not been reported any reproductive condition. found positive correlations between endometriosis all-cause r g =0.585, =8.98E-14), polycystic ovary syndrome anovulatory =0.403,...
Abstract Diverticular disease is characterized by pouches (that is, diverticulae) due to weakness in the bowel wall, which can become infected and inflamed causing diverticulitis, with potentially severe complications. Here, we test 32.4 million sequence variants identified through whole-genome sequencing (WGS) of 15,220 Icelanders for association diverticular (5,426 cases) its more form diverticulitis (2,764 cases). Subsequently, 16 are followed up a sample from Denmark (5,970 cases, 3,020...
Blood transfusion is an essential component of a modern healthcare system. Because knowledge about blood donor demography may inform the design strategies for recruitment and retention, we used nationwide registers to characterize entire population donors in Denmark 2010.The study comprised all Danes age range eligible donation (N = 3,236,753) at end 2010. From Scandinavian Donations Transfusions (SCANDAT) register, identified 174,523 persons who donated Danish banks least once The...