A5035345936- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Climate Change and Health Impacts
- Urinary Tract Infections Management
- Kawasaki Disease and Coronary Complications
- Respiratory viral infections research
- COVID-19 and Mental Health
- Salmonella and Campylobacter epidemiology
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Health disparities and outcomes
- COVID-19 Pandemic Impacts
- Data-Driven Disease Surveillance
- Listeria monocytogenes in Food Safety
- Influenza Virus Research Studies
- COVID-19 Impact on Reproduction
- Viral Infections and Vectors
- Viral Infections and Immunology Research
- Zoonotic diseases and public health
- Reproductive Health and Contraception
- Inflammasome and immune disorders
- Pericarditis and Cardiac Tamponade
- Pneumocystis jirovecii pneumonia detection and treatment
Statens Serum Institut
2015-2024
Norwegian Institute of Public Health
2018-2019
European Centre for Disease Prevention and Control
2019
University of Copenhagen
2012
By 9 December 2021, 785 SARS-CoV-2 Omicron variant cases have been identified in Denmark. Most were fully (76%) or booster-vaccinated (7.1%); 34 (4.3%) had a previous infection. The majority of with available information reported symptoms (509/666; 76%) and most infected Denmark (588/644; 91%). One five cannot be linked to cases, indicating widespread community transmission. Nine hospitalised, one required intensive care no deaths registered.
Multisystem inflammatory syndrome in children (MIS
Abstract The newly found Omicron SARS-CoV-2 variant of concern has rapidly spread worldwide. carries numerous mutations in key regions and is associated with increased transmissibility immune escape. recently been divided into four subvariants substantial genomic differences, particular between BA.1 BA.2. With the surge BA.2, a large number reinfections from earlier cases observed, raising question whether BA.2 specifically can escape natural immunity acquired shortly after infection. To...
Since December 2016, excess all-cause mortality was observed in many European countries, especially among people aged ≥ 65 years. We estimated and influenza-attributable 19 countries/regions. Excess primarily explained by circulation of influenza virus A(H3N2). Cold weather snaps contributed some countries. The pattern similar to the last major A(H3N2) season 2014/15 Europe, although starting earlier line with early start.
Introduction of the Omicron variant caused a steep rise in SARS-CoV-2 infections despite high vaccination coverage Danish population. We used blood donor serosurveillance to estimate percentage recently infected residents similarly aged background population with no known comorbidity.To detect antibodies induced due recent infection, and not vaccination, we assessed anti-nucleocapsid (anti-N) immunoglobulin G (IgG) samples. Individual level data on RT-PCR results status were available....
Since December 2014 and up to February 2015, the weekly number of excess deaths from all-causes among individuals?≥?65 years age in 14 European countries have been significantly higher than four previous winter seasons. The rise unspecified mortality coincides with increased proportion influenza detection surveillance schemes a main predominance A(H3N2) viruses seen throughout Europe current season, though cold snaps other respiratory infections may also had an effect.
Abstract Seroprevalence studies have proven an important tool to monitor the progression of coronavirus disease 2019 (COVID-19) pandemic. We present results consecutive population-based seroprevalence surveys performed in Denmark 2020. In spring, late summer and autumn/winter 2020, invitation letters including a questionnaire covering symptoms were sent representative samples population above 12 years parents children below 18 sample. Blood analysed for total Ig estimates per segment...
Since 2010, Denmark has included the 13-valent pneumococcal conjugated vaccine (PCV-13) in childhood immunization programme. However, serotype 3 remains as an important cause of invasive disease (IPD) Denmark. IPD surveillance data (1999–2016) was used to calculate incidence and age-distribution IPD, effect PCV-13 on examined. The age group below 65 years 0.51/100,000 pre PCV-13, 0.45/100,000 post PCV-13. In 0–4 years, 0.28/100,000 0.16/100,000 Serotype elderly showed a mean 4.27/100,000...
Burden of disease studies measure the public health impact a in society. The aim this study was to quantify direct burden COVID-19 first 12 months epidemic Denmark.We collected national surveillance data on positive individuals for SARS-CoV-2 with RT-PCR, hospitalization data, and mortality reported period between 26th February, 2020 25th 2021. We calculated disability adjusted life years (DALYs) based European Disease Network consensus model, which considers mild, severe, critical states,...
In April 2019, a cross-border outbreak of Yersinia entercolitica O3 was identified in Sweden and Denmark confirmed using whole genome sequencing. Close collaboration with representatives from human food authorities helped direct resources investigations. Combined epidemiological trace-back investigations pointed to imported fresh spinach as the vehicle highlight that other vehicles Y. enterocolitica outbreaks than pork should be considered.
Objectives To investigate the relationship between different indicators of socioeconomic position and risk spontaneous abortion. Design Cohort study. Setting 1996–2002, Denmark. Participants All first time participants, a total 89 829 pregnant women, enrolled in Danish National Birth were included present Overall, 4062 pregnancies ended Information on education, income labour market attachment year before pregnancy was drawn from national registers. Main outcome measure Spontaneous abortion,...
Whole-genome sequencing (WGS) has revolutionized surveillance of infectious diseases. Disease outbreaks can now be detected with high precision, and correct attribution infection sources been improved. Listeriosis, caused by the bacterium Listeria monocytogenes, is a foodborne disease case fatality rate large proportion outbreak-related cases. Timely recognition listeriosis precise allocation food are important to prevent further infections promote public health. We report WGS-based...
Our aim was to evaluate the results of automated surveillance Lyme neuroborreliosis (LNB) in Denmark using national microbiology database (MiBa), and describe epidemiology laboratory-confirmed LNB at a level. MiBa-based includes electronic transfer laboratory results, contrast statutory based on manually processed notifications. Antibody index (AI) testing is recommend test support diagnosis Denmark. In period from 2010 2012, 217 clinical cases were notified system, while 533 reported AI...
Abstract Identification of societal activities associated with SARS-CoV-2 infection may provide an evidence base for implementing preventive measures. Here, we investigated potential determinants in Denmark a situation where society was only partially open. We conducted national matched case-control study. Cases were recent RT-PCR test-positives, while controls, individually on age, sex and residence, had not previously tested positive SARS-CoV-2. Questions concerned person contact community...
Measures to restrict physical inter-personal contact in the community have been widely implemented during COVID-19 pandemic. We studied determinants for infection with SARS-CoV-2 aim of informing future public health measures. conducted a national matched case-control study among unvaccinated not previously infected adults aged 18–49 years. Cases were selected those testing positive by RT-PCR over five-day period June 2021. Controls from population register and individually on age, sex...
Myopericarditis is a severe adverse event to COVID-19 vaccines.1 The highest risk has been reported in males aged 12-29 years.2-4 According the US Vaccine Adverse Event Reporting System (VAERS), children 5-11 years low with 11 cases following 8.7 million doses of Pfizer-BioNTech vaccine.5 However, these numbers may be underestimated due underreporting.6.
Background Seroprevalence studies have proven an important tool to monitor the progression of coronavirus disease 2019 (COVID-19) epidemic. We present results consecutive population-based seroprevalence surveys performed in Denmark 2020. Methods Invitation letters including a questionnaire covering symptoms were sent representatively drawn samples population spring, late summer and autumn/winter Blood from participants taken at public test-centers analyzed for total Ig estimates per segment...
Abstract In Denmark, outbreaks of salmonella with more than 20 cases have become rare. November 2018, an outbreak monophasic Salmonella Typhimurium was detected and investigation initiated the aim identifying source controlling outbreak. Outbreak were defined based on core genome multilocus sequence types. We conducted hypothesis-generating interviews, a matched case-control study, food sampling trace-back investigations. identified 49 distributed across Denmark. univariable analyses...
Abstract Background Extensive measures to control spread of SARS-CoV-2 have led limited access education for millions children and adolescents during the COVID-19 pandemic. Education schools is vital adolescents’ learning, health, wellbeing. Based on high vaccine uptake low incidence levels, Nordic countries (Denmark, Finland, Iceland, Norway Sweden) decided start academic year 2021/22 with open in-person teaching moderate mitigation measures. We describe trends in infections vaccination...
Abstract Background We aimed to estimate the prevalence of faecal carriage extended-spectrum cephalosporin (ESC) resistant E. coli and K. pneumoniae (ESCr-EK) vancomycin enterococci (VRE) in patients upon hospital admission identify factors associated with better target interventions guide empirical antibiotic treatment. Methods Between October 2014 December 2016, we recruited admitted a Norwegian university hospital. A rectal swab questionnaire covering possible risk for colonisation were...
In September 2017, a cluster of monophasic Salmonella Typhimurium isolates was identified at the National Reference Laboratory for Enteropathogenic Bacteria in Norway. We investigated to identify source and implement control measures. defined case as person with laboratory-confirmed salmonellosis outbreak strain multiple locus variable-number tandem repeat analysis type. conducted descriptive epidemiological environmental investigations performed whole genome sequencing (WGS) core accessory...
AimThe aim of this study was, for the first time, to describe in detail epidemiology and impact norovirus outbreaks healthcare institituions (HCIs) Norway identify areas which may improve outbreak response.MethodsAn analysis all reported hospitals long-term-care facilities (LTCFs) was carried out from week 34, 2005 33, 2018. Seasonality, symptoms number cases among personnel patients were described.FindingsA total 20,544 cases, including 7044 965 outbreaks; 740 LTCFs 225 hospitals. Median...