A5084572892- Salmonella and Campylobacter epidemiology
- Viral gastroenteritis research and epidemiology
- Clostridium difficile and Clostridium perfringens research
- Veterinary medicine and infectious diseases
- Listeria monocytogenes in Food Safety
- Bacteriophages and microbial interactions
- Escherichia coli research studies
- Microscopic Colitis
- Gut microbiota and health
- Bacterial Identification and Susceptibility Testing
- Parasitic Infections and Diagnostics
- Amoebic Infections and Treatments
- Aquaculture disease management and microbiota
- Peripheral Neuropathies and Disorders
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Food Safety and Hygiene
- Nosocomial Infections in ICU
- Probiotics and Fermented Foods
- Helicobacter pylori-related gastroenterology studies
- Vibrio bacteria research studies
- Inflammatory Bowel Disease
- Urinary Tract Infections Management
- Mycobacterium research and diagnosis
- Fecal contamination and water quality
Zealand University Hospital
2021-2024
Zealand University Hospital Køge
2022-2024
Slagelse Hospital
2013-2023
Statens Serum Institut
2001-2023
University of Copenhagen
2018-2023
Odense University Hospital
2023
Gentofte Hospital
2023
Public Health Agency of Sweden
2018
Larsen & Toubro (India)
2018
Ontario Institute for Cancer Research
2017
The incidence of human Campylobacter jejuni and C. coli infections has increased markedly in many parts the world last decade as number quinolone-resistant and, to a lesser extent, macrolide-resistant strains causing infections. We review macrolide quinolone resistance track trends clinical isolates relation use these agents food animals. Susceptibility data suggest that erythromycin other macrolides should remain drugs choice most regions, with systematic surveillance control measures...
Food-borne salmonella infections have become a major problem in industrialized countries. The strain of Salmonella enterica serotype typhimurium known as definitive phage type 104 (DT104) is usually resistant to five drugs: ampicillin, chloramphenicol, streptomycin, sulfonamides, and tetracycline. An increasing proportion DT104 isolates also reduced susceptibility fluoroquinolones.The Danish surveillance program determines the types all strains from food chain, case suspected outbreaks,...
ABSTRACT The aims of this study were to investigate the prevalence campylobacteria including Campylobacter jejuni subsp. ( C. ) and coli in human clinical samples from healthy individuals reevaluate efficacies conventional selective methods for isolation spp. Two charcoal-based media, modified charcoal cefoperazone deoxycholate agar (mCCDA) cefoperazone-amphotericin-teicoplanin (CAT) agar, compared with Skirrow's blood-based medium a filter method (filter) applied yeast-enriched blood agar....
A case control study comprising 282 cases and 319 matched controls was conducted in Denmark during 1996-7. Two estimates of the odds ratio (OR) were determined for each risk factor with without 'protective factors' fitted into final model. Consumption undercooked poultry (OR 4.5; 8.2), consumption red meat at a barbecue 2.3; 4.1), grapes 1.6; 2.8) drinking unpasteurized milk 11.8) identified as factors both models. Frequent pork chops 4.4) daily contact domestic animals pets one two models...
We present an analysis of strain and patient factors associated with the development bloody diarrhea hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark a 6-year period. Of 343 STEC patients, developed 36.4% HUS 6.1%. In multivariate logistic regression model, risk for were eae stx2 genes, O groups O157 O103, increasing age. Risk presence (odds ratio [OR] 18.9) (OR undefined) being child, having diarrhea. group O157, although...
Abstract We report the findings of a case-control study risk factors for sporadic cases human campylobacteriosis in Denmark. In 3 different analytical models, main domestic factor identified was eating fresh, unfrozen chicken. Specifically, 28 74 domestically acquired case-patients were exposed to fresh chicken compared with 21 114 controls (multivariate matched odds ratio 5.8; 95% confidence interval 2.1–15.9). contrast, from other poultry, including previously frozen chicken, only...
The number of human cases enteritis caused by Campylobacter jejuni and C. coli is increasing in Denmark other European countries. No systemic typing has earlier been performed on isolates Danish origin. primary purpose this study was to provide a serotype distribution from patients the major food production animals. In addition, occurrence intestinal carriers thermophilic campylobacters among these animals examined. nationwide survey, individual isolation rate 36% for broiler chickens, 47%...
The MICs of 16 antimicrobial agents were determined for 202 Campylobacter jejuni isolates, 123 coli and 6 lari isolates from humans food animals in Denmark. C. originated (75), broilers (95), cattle (29), pigs (3); the (7), (17), (99); (5) (1). All susceptible to apramycin, neomycin, gentamicin. Only a few resistant one or more agents. Resistance tetracycline was common among (11%) than (0 2%). More resistance streptomycin found (10%) those (4%) (1%). A greater proportion other tested....
Abstract We integrated data on quinolone and macrolide susceptibility patterns with epidemiologic typing from Campylobacter jejuni C. coli infections in two Danish counties. The mean duration of illness was longer for 86 patients quinolone-resistant (median 13.2 days) than 381 quinolone-sensitive 10.3 days, p = 0.001). Foreign travel, eating fresh poultry other chicken turkey, swimming were associated increased risk infection. Eating (of presumably origin) a decreased risk. Typing showed an...
ABSTRACT Six methods for subtyping of Campylobacter jejuni were compared and evaluated with a collection 90 isolates from poultry, cattle, sporadic human clinical cases as well waterborne outbreak. The applied Penner heat-stable serotyping; automated ribotyping (RiboPrinting); random amplified polymorphic DNA typing (RAPD); pulsed-field gel electrophoresis (PFGE); restriction fragment length polymorphisms the flagellin gene, flaA ( fla -RFLP); denaturing gradient -DGGE). on basis their...
We describe here an examination of the validity molecular types Campylobacter jejuni as defined by separation SmaI-digested DNA using pulsed-field gel electrophoresis (PFGE), recently suggested part a subtyping scheme. Thirty-four Danish strains from humans, water, poultry and cattle were assigned to one six SmaI 'profile groups' (PGs), with two additional included genotypically distinct controls. The interstrain relationships reexamined PFGE SalI, KpnI BamHI-digested DNA, also serotyping...
Cases of cryptosporidiosis in humans have been reported with strong indication transmission from rodents. Here, we report seven new human cases involving rodent-adapted species (
ABSTRACT The incidence of human infection with Campylobacter jejuni is increasing in most developed countries and the reason for this largely unknown. Although poultry meat considered to be a major source, it evident that other reservoirs exist, possibly common humans poultry. Environmental sources are believed important broiler chicken flocks. We investigated potential importance wildlife as source commercial flocks by comparing serotype distributions, fla types, macrorestriction profiles...
Campylobacter concisus infections of the gastrointestinal tract can be accompanied by diarrhea and inflammation, whereas colonization human oral cavity might have a commensal nature. We focus on pathophysiology C. effects different clinical fecal strains HT-29/B6 colon cells. Six eight were isolated. Mucus-producing epithelial monolayers infected with strains. Transepithelial electrical resistance (R(t)) tracer fluxes molecule size measured in Ussing chambers. Tight junction (TJ) protein...
Inflammatory Bowel disease (IBD) is traditionally divided into Crohn´s (CD) and ulcerative colitis (UC). UC a relapsing non-transmural inflammatory that restricted to the colon characterized by flare-ups of bloody diarrhea. CD chronic, segmental localized granulomatous can affect any part entire gastrointestinal tract. Ileo-anal pouch procedure restoring functionality rectum after colectomy. IBD multifactorial flares are probably triggered changes in intestinal microbiota followed an...
Summary Background A defined bacterial mixture could be a safer alternative to faecal microbiota transplantation (FMT). Aims To compare the efficacy of 12‐strain termed rectal bacteriotherapy with either FMT or vancomycin for recurrent Clostridioides difficile infection (CDI) in an open‐label 3‐arm randomised controlled trial. Methods We screened all individuals positive C from May 2017 March 2019. Persons laboratory‐confirmed CDI were included. Before and bacteriotherapy, we pre‐treated...
Abstract Purpose To analyze the nationwide incidence of Salmonella infections in Denmark from 2013 to 2022. Methods Confirmed cases enterica subsp. were examined using National Register Enteric Pathogens during 2013–2022. Proportions, rates (IR), relative risk (RR), and 95% confidence intervals (CI) calculated assess differences serotypes, invasiveness, age, sex, travel exposure. Results We identified 9,944 Danish cases, with an average annual rate 16.9 per 100,000 inhabitants, declining...
Between November and December 2021, the first ever recorded outbreak of enteroinvasive Escherichia coli in Denmark occurred at national scale. We describe investigation this outbreak, which was initially recognised early 2021. A total 88 cases (58 female; 30 male) with a median age 52 years (range: 0-91) were detected by PCR-based diagnostic methods. Case ascertainment complicated current culture-free procedures, only 34 confirmed culture, serotyping whole genome sequencing. Isolates from...