A5034490180- Gut microbiota and health
- Inflammatory Bowel Disease
- Microscopic Colitis
- Escherichia coli research studies
- Clostridium difficile and Clostridium perfringens research
- Helicobacter pylori-related gastroenterology studies
- Pediatric health and respiratory diseases
- Autoimmune and Inflammatory Disorders
- Infant Health and Development
- Diet and metabolism studies
- Music Therapy and Health
- Gastrointestinal motility and disorders
- Bacteriophages and microbial interactions
- Inflammation biomarkers and pathways
- Intensive Care Unit Cognitive Disorders
- Empathy and Medical Education
- Antibiotic Resistance in Bacteria
- Respiratory and Cough-Related Research
- IL-33, ST2, and ILC Pathways
- Vibrio bacteria research studies
- Nutritional Studies and Diet
- Probiotics and Fermented Foods
Statens Serum Institut
2015-2024
Roskilde University
2024
University of Copenhagen
2015-2016
Intestinal dysbiosis in inflammatory bowel disease (IBD) patients depend on activity. We aimed to characterize the microbiota after 7 years of follow-up an unselected cohort IBD according activity and severity. Fifty eight Crohn's (CD) 82 ulcerative colitis (UC) were included. Disease was assessed by Harvey-Bradshaw Index for CD Simple Clinical Colitis Activity UC. Microbiota diversity 16S rDNA MiSeq sequencing. In UC with active aggressive richness (number OTUs, p = 0.018 0.013,...
Most microbiome research related to airway diseases has focused on the gut microbiome. This is despite advances in culture independent microbial identification techniques revealing that even healthy lungs possess a unique dynamic conceptual change raises question; if lung could be causally linked local dysbiosis of microbiota. Here, we manipulate murine and microbiome, order show microbiota can changed experimentally. We have used four different approaches: inflammation by exposure carbon...
The potential of Escherichia coli (E. coli) isolated from inflammatory bowel disease (IBD) patients to damage the integrity intestinal epithelium was investigated.E. strains with ulcerative colitis (UC) and healthy controls were tested for virulence capacity by molecular techniques cytotoxic assays transepithelial electric resistance (TER). E. isolate p19A selected, deletion mutants created alpha-hemolysin (α-hemolysin) (hly) clusters necrotizing factor type 1 (cnf1). Probiotic Nissle...
Inflammatory Bowel disease (IBD) is traditionally divided into Crohn´s (CD) and ulcerative colitis (UC). UC a relapsing non-transmural inflammatory that restricted to the colon characterized by flare-ups of bloody diarrhea. CD chronic, segmental localized granulomatous can affect any part entire gastrointestinal tract. Ileo-anal pouch procedure restoring functionality rectum after colectomy. IBD multifactorial flares are probably triggered changes in intestinal microbiota followed an...
Abstract E. coli of the phylogenetic group B2 harbouring Extra intestinal Pathogenic Escherichia (ExPEC) genes are frequently seen as colonizers intestine in patients with active ulcerative colitis (UC). In this study, we describe influence Nissle (EcN) add-on treatment to conventional therapies UC. For study one hundred UC were randomized ciprofloxacin or placebo for 1 week followed by EcN 7 weeks. Stool samples collected at weeks 0, 1, 8, 12, where characterized and fecal calprotectin was...
Probiotics have been described to influence host health and prevent the risk of obesity by gut microbiome (GM) modulation. In a randomized double-blinded placebo-controlled feasibility study, we investigated whether Vivomixx® multi-strain probiotics administered 50 women with during pregnancy altered GM composition perinatal outcomes their infants up 9 months after birth. The mothers were followed four visits birth: at 3 d, 3, 6, delivery. monitored anthropometric measurements, fecal sample...
Abstract Aim Diarrhoea is very common in children attending day care centres. The aim of this study was to examine certain predisposing risk factors for an association with diarrhoea, including foreign travel, treatment antibiotics, having household pets, infant colic, bottle feeding, using a pacifier and low birthweight. Methods A dynamic one‐year follow‐up cohort comprising 179 from 36 centres conducted September 2009 July 2013 Copenhagen, Denmark. Questionnaires were sent the children's...
Objective: Fecal calprotectin is a noninvasive marker of intestinal inflammation used to distinguish between functional and organic bowel diseases evaluate disease activity among patients with Inflammatory Bowel Disease (IBD). The goal this study was compare three different ELISA tests measuring in their accuracy detect IBD active or inactive disease. Material methods: This includes total 148 fecal samples, 96 from previously confirmed diagnosis 52 healthy controls, aged 25 86 18 67 years,...
Enteroaggregative Escherichia coli (EAEC) is frequently isolated from sporadic cases of diarrhea and in outbreaks gastroenteritis several regions the world. The pathophysiology EAEC continues to be enigmatic efficacy antibiotic treatment EAEC-associated has been discussed. Since level resistance increasing, it essential restrict use antibiotics prevent further development. We aimed investigate strains adult Danish patients suffering healthy controls. examined strains, clinical response...