A5000203733- Salmonella and Campylobacter epidemiology
- Psychedelics and Drug Studies
- Neurotransmitter Receptor Influence on Behavior
- Viral gastroenteritis research and epidemiology
- Antimicrobial Resistance in Staphylococcus
- Functional Brain Connectivity Studies
- Animal Nutrition and Physiology
- Chemical synthesis and alkaloids
- Tryptophan and brain disorders
- Microbial infections and disease research
- Circadian rhythm and melatonin
- Mental Health Research Topics
- Paranormal Experiences and Beliefs
- Veterinary medicine and infectious diseases
- Food Safety and Hygiene
- Forensic Toxicology and Drug Analysis
- Bacterial Identification and Susceptibility Testing
- Neural and Behavioral Psychology Studies
- Clostridium difficile and Clostridium perfringens research
- Bacteriophages and microbial interactions
- Optical Imaging and Spectroscopy Techniques
- Photoreceptor and optogenetics research
- Insect Utilization and Effects
- Vibrio bacteria research studies
- Complementary and Alternative Medicine Studies
Rigshospitalet
2015-2025
Svendborg Sygehus
2022-2025
Copenhagen University Hospital
2013-2024
Odense University Hospital
2024
University of Copenhagen
2016-2022
Aarhus University
2000-2019
Institute of Neurobiology
2015
Technical University of Denmark
1997-2013
Danish Ministry of Food, Agriculture and Fisheries
1998-2005
Danish Technological Institute
2002-2003
Abstract Objective To evaluate the feasibility and prophylactic effect of psilocybin as well its effects on hypothalamic functional connectivity (FC) in patients with chronic cluster headache (CCH). Background CCH is an excruciating difficult‐to‐treat disorder incompletely understood pathophysiology, although dysfunction has been implicated. Psilocybin may have beneficial effects, but clinical evidence limited. Methods In this small open‐label trial, 10 were included maintained diaries for...
Journal Article Prevalence and antimicrobial susceptibility of thermophilic Campylobacter in organic conventional broiler flocks Get access O.E. Heuer, Heuer Danish Veterinary Laboratory, Department Poultry, Fish Fur Animals, ÅrhusDepartment Microbiology, Royal Agricultural University, Frederiksberg, Denmark Dr Hangøvej 2, DK‐8200 Århus N, (e‐mail: oeh@svs.dk). Search for other works by this author on: Oxford Academic Google Scholar K. Pedersen, Pedersen J.S. Andersen, Andersen Zoonosis...
The MICs of 16 antimicrobial agents were determined for 202 Campylobacter jejuni isolates, 123 coli and 6 lari isolates from humans food animals in Denmark. C. originated (75), broilers (95), cattle (29), pigs (3); the (7), (17), (99); (5) (1). All susceptible to apramycin, neomycin, gentamicin. Only a few resistant one or more agents. Resistance tetracycline was common among (11%) than (0 2%). More resistance streptomycin found (10%) those (4%) (1%). A greater proportion other tested....
This study describes the establishment and first results of a continuous surveillance system antimicrobial resistance among bacteria isolated from pigs, cattle broilers in Denmark. The three categories tested were: 1) indicator ( Escherichia coli, Enterococcus faecalis, faecium ), 2) zoonotic Campylobacter coli/jejuni, Salmonella enterica, Yersinia enterocolitica 3) animal pathogens E. Staphylococcus aureus , coagulase‐negative staphylococci (CNS), hyicus, Actinobacillus pleuropneumoniae )....
The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of cerebral serotonergic targets by psilocin (active metabolite). serotonin 2A receptor critically mediates these altering distributed neural processes that manifest as increased entropy, reduced functional connectivity (FC) within discrete brain networks (i.e., integrity) and FC between segregation). Reduced integrity the default mode network (DMN) is proposed to play a particularly prominent role in...
The MICs of vancomycin and avoparcin were determined for isolates Enterococcus faecium faecalis recovered from the feces humans animals in Denmark. Two hundred twenty-one 376 (59%) E. 2 133 (1.5%) resistant to (MICs, 128 > or = 256 micrograms/ml), all vancomycin-resistant 64 micrograms/ml). All examined carried vanA, vanX, vanR genes, suggesting that a gene cluster similar transposon Tn1546 was responsible resistance.
The use of the glycopeptide growth promoter avoparcin was discontinued in Denmark 1995 following concerns that vancomycin-resistant Enterococcus faecium occurring as a result its could be transferred to humans via food. present study is an analysis results obtained by continuous surveillance antimicrobial resistance (DANMAP) with aim determining effect ban on occurrence among E. isolated from broilers and pigs. Among isolates broilers, proportion were resistant glycopeptides has shown...
Aims: To study the prevalence of seven virulence and toxin genes, cytolethal distending (CDT) production Campylobacter jejuni C. coli isolates from Danish pigs cattle. Methods Results: The presence cadF, ceuE, virB11, flaA, cdtA, cdtB, cdtC cdt gene cluster among 40 was detected by polymerase chain reaction. CDT determined on Vero, colon 205 chicken embryo cells. ceuE cdtB genes were 100% isolates. cdtA found in 95·0 90·0% isolates, respectively. 82·5% Only 7·5% positive for virB11....
We describe here an examination of the validity molecular types Campylobacter jejuni as defined by separation SmaI-digested DNA using pulsed-field gel electrophoresis (PFGE), recently suggested part a subtyping scheme. Thirty-four Danish strains from humans, water, poultry and cattle were assigned to one six SmaI 'profile groups' (PGs), with two additional included genotypically distinct controls. The interstrain relationships reexamined PFGE SalI, KpnI BamHI-digested DNA, also serotyping...
Cross-sectional neuroimaging studies in non-depressed individuals have demonstrated an inverse relationship between daylight minutes and cerebral serotonin transporter; this is modified by serotonin-transporter-linked polymorphic region short allele carrier status. We here present data from the first longitudinal investigation of seasonal transporter fluctuations both patients with affective disorder healthy individuals. Eighty 11 C-DASB positron emission tomography scans were conducted to...
Psilocybin is a serotonergic psychedelic with psychoactive effects mediated by serotonin 2A receptor (5-HT2AR) activation. It produces an acute altered state of consciousness unique phenomenology that can be temporally characterized three intensity phases: onset effect, peak plateau and return to normal consciousness.We evaluated whether pre-drug brain 5-HT2AR binding predicted the phases psilocybin subjective drug (SDI) retrospective self-report mystical type experiences in healthy...
Psilocin, the neuroactive metabolite of psilocybin, is a serotonergic psychedelic that induces an acute altered state consciousness, evokes lasting changes in mood and personality healthy individuals, has potential as antidepressant treatment. Examining effects psilocin on resting-state time-varying functional connectivity implicates network-level motifs may underlie behavioral clinical effects. Evaluate association between (tvFC) characteristics plasma level (PPL) subjective drug intensity...
In order to elucidate the rate of thermophilic Campylobacter spp. carriage in Danish broiler production and identify risk factors for occurrence campylobacter flocks, a total 88 randomly selected flocks were tested infection, subsequent study based on questionnaire was conducted. The sample material comprised cloacal swabs from live birds before slaughter, neck skin samples carcasses at end processing line. A 52% found spp.-positive slaughter. At processing, 24% positive. species...
Living in a household with dog or cat has previously been identified as significant risk factor for acquiring campylobacteriosis, particular, reference to Campylobacter upsaliensis infection. In cross-sectional study carried out Denmark between August and December 1996, 72 healthy puppies 42 kittens, aged 11 17 weeks, were sampled fecal campylobacter shedding by culture of rectal swab specimens on blood-free agar base cefoperazone at 32 mg/liter amphotericin 10 8 mg/liter, teicoplanin 4...
We evaluated the role of beetles infesting broiler chicken rearing facilities as potential reservoirs for Salmonella enterica infections between successive flocks. In addition, their thermophilic Campylobacter spp. was also investigated. Fourteen houses located at 11 different farms were included in study. The nonrandomly selected on basis salmonella status; nine persistently contaminated with whereas five negative.For each house, two consecutive flocks (i.e., 28 all) well collected during...
Communication between the amygdala and other brain regions critically regulates sensitivity to threat, which has been associated with risk for mood affective disorders. The extent these neural pathways are genetically determined or correlate risk-related personality measures is not fully understood. Using functional magnetic resonance imaging, we evaluated independent interactive effects of 5-HTTLPR genotype neuroticism on connectivity during an emotional faces paradigm in 76 healthy...
Background Psilocybin-induced mystical-type experiences are associated with lasting positive psychological outcomes. Recent studies indicate that trait mindfulness is increased 3 months after psilocybin intake, preceded by decreases in neocortical serotonin 2A receptor (5-HT R) binding. However, the association between psilocybin-induced and subsequent changes remains unexplored, as does pre-drug 5-HT R binding healthy brain. Aim We evaluated whether induced increases volunteers, experience...
Psilocin, the active metabolite of psilocybin, is a psychedelic and agonist at serotonin 2A receptor (5-HT2AR) that has shown positive therapeutic effects for brain disorders such as depression. To elucidate we directly compared acute 5-HT2AR (psilocybin) antagonist (ketanserin) on cerebral blood flow (CBF) using pseudo-continuous arterial spin labeling magnetic resonance imaging (MRI) in single-blind, cross-over study 28 healthy participants. We evaluated associations between plasma...