A5015895924- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Psychedelics and Drug Studies
- Treatment of Major Depression
- Receptor Mechanisms and Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Radiopharmaceutical Chemistry and Applications
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Schizophrenia research and treatment
- Diet and metabolism studies
- Nicotinic Acetylcholine Receptors Study
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Chemical synthesis and alkaloids
- Drug Transport and Resistance Mechanisms
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurological disorders and treatments
University of Copenhagen
2016-2025
Rigshospitalet
2016-2025
Copenhagen University Hospital
2016-2025
National Institutes of Health
2024
Frederiksberg Hospital
1990-2024
Institute of Neurobiology
2007-2024
AbbVie (United States)
2024
PureTech (United States)
2024
Sage (United Kingdom)
2024
Biogen (United States)
2024
Brain-derived neurotrophic factor (BDNF) is involved in synaptic plasticity, neuronal differentiation and survival of neurons. Observations decreased serum BDNF levels patients with neuropsychiatric disorders have highlighted the potential as a biomarker, but so far there been no studies directly comparing blood to brain different species. We examined blood, serum, plasma brain-tissue three mammalian species: rat, pig, mouse, using an ELISA method. As control, we included analysis tissue...
Abstract Neurotransmitter receptors support the propagation of signals in human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, there exists no comprehensive atlas receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative 19 transporters across nine different neurotransmitter systems. We found that profiles...
The serotonin (5-hydroxytryptamine, 5-HT) system modulates many important brain functions and is critically involved in neuropsychiatric disorders. Here, we present a high-resolution, multidimensional, vivo atlas of four the human brain's 5-HT receptors (5-HT 1A , 1B 2A 4 ) transporter (5-HTT). created from molecular structural high-resolution neuroimaging data consisting positron emission tomography (PET) magnetic resonance imaging (MRI) scans acquired total 210 healthy individuals....
Species differences occur in the brain concentrations of drugs, but reasons for these are not yet apparent. This study was designed to compare uptake three radiolabeled P-glycoprotein (P-gp) substrates across species using positron emission tomography. Brain and brain-to-plasma ratios were compared; [<sup>11</sup>C]verapamil rats, guinea pigs, monkeys; [<sup>11</sup>C](<i>S</i>)-(2-methoxy-5-(5-trifluoromethyltetrazol-1-yl)-phenylmethylamino)-2(<i>S</i>)-phenylpiperidine (GR205171) monkeys,...
Significance In a technical tour de force, we have created framework demonstrating the underlying fundamental principles of bidirectional coupling neuronal and neurotransmitter dynamical systems. Specifically, in present study, combined multimodal neuroimaging data to causally explain functional effects specific serotoninergic receptor (5-HT 2A R) stimulation with psilocybin healthy humans. Longer term, this could provide better understanding why is showing considerable promise as...
A single dose of psilocybin, a psychedelic and serotonin 2A receptor (5-HT2AR) agonist, may be associated with antidepressant effects. The mechanism behind its antidepressive action is unknown but could linked to increased synaptogenesis down-regulation cerebral 5-HT2AR. Here, we investigate if psilocybin changes synaptic vesicle protein (SV2A) 5-HT2AR density in the pig brain. Twenty-four awake pigs received either 0.08 mg/kg or saline intravenously. Twelve (n = 6/intervention) were...
BackgroundAlcohol use disorder (AUD) is a chronic, relapsing brain that accounts for 5% of deaths annually, and there an urgent need to develop new targets therapeutic intervention. The glucagon-like peptide-1 (GLP-1) receptor agonist exenatide reduces alcohol consumption in rodents nonhuman primates, but its efficacy patients with AUD unknown.MethodsIn randomized, double-blinded, placebo-controlled clinical trial, treatment-seeking were assigned receive (2 mg subcutaneously) or placebo once...
Introduction Alcohol use disorder (AUD) is a massive burden for the individual, relatives and society. Despite this, treatment gap wide compared with other mental health disorders. Treatment options are sparse, only three Food Drug Administration (FDA)-approved pharmacotherapies. Glucagon-like peptide-1 (GLP-1) receptor agonists have shown promising effects in reducing alcohol consumption preclinical experiments, clinical trials high demand to investigate these potentially beneficial...
Background and Purpose —Under normal circumstances, autoregulation maintains cerebral blood flow (CBF) constant within a wide range of mean arterial pressure (MAP). It remains unknown whether patients resuscitated from cardiac arrest have preserved CBF autoregulation. In this study, was investigated the first 24 hours after resuscitation arrest. Methods —Eighteen 6 healthy volunteers had relative changes in determined by transcranial Doppler velocity (V ) middle artery during stepwise rise...
This study validates transcranial Doppler sonography (TCD) for determination of the lower limit cerebral blood flow (CBF) autoregulation and establishes a relation between global CBF mean velocity (Vmean) in middle artery. Relative changes Vmean were compared 12 normal volunteers (2 women 10 men; median age, 30 years [range, 21 to 61 years]). Catheters was placed left radial artery bulb right internal jugular vein, respectively. Baseline measured by single-photon emission computed tomography...
Arterial blood pressure and cardiac output are often reduced in patients with chronic heart failure (CHF). Counterregulatory mechanisms increased neurohormonal activation changes the distribution of assumed to secure vital organ perfusion. However, clinical examination CHF frequently reveals neurological symptoms dizziness memory problems, suggesting altered brain In this study we determined whether cerebral flow (CBF) is New York Heart Association (NYHA) functional class III IV (n=12)...