A5066765660- Vector-borne infectious diseases
- COVID-19 and Mental Health
- COVID-19 epidemiological studies
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Leptospirosis research and findings
- Parasites and Host Interactions
- Vector-Borne Animal Diseases
- Respiratory viral infections research
- Viral Infections and Outbreaks Research
- Infection Control and Ventilation
- Clostridium difficile and Clostridium perfringens research
- SARS-CoV-2 and COVID-19 Research
- Food Safety and Hygiene
- Toxin Mechanisms and Immunotoxins
- Nosocomial Infections in ICU
- Invertebrate Immune Response Mechanisms
- Studies on Chitinases and Chitosanases
- Microscopic Colitis
- Andrographolide Research and Applications
- Antibiotic Use and Resistance
- Advanced battery technologies research
- Antimicrobial Resistance in Staphylococcus
- Neuroinflammation and Neurodegeneration Mechanisms
- Bacterial Identification and Susceptibility Testing
Akershus University Hospital
2012-2024
Oslo University Hospital
2012-2024
Norwegian Institute of Public Health
2019-2023
University of Oslo
2012-2016
In response to the coronavirus disease (COVID-19) pandemic, most countries implemented school closures. Norway, schools closed on 13 March 2020. The evidence of effect transmission was limited, while negative consequences were evident. Before reopening, risk-assessment for paediatric risk groups performed, concluding that children can attend with few conditions requiring preventative homeschooling. We here present infection prevention and control guidelines primary recommendations groups.
Scrub typhus, caused by Orientia tsutsugamushi, is endemic in the Asia-Pacific region. Mortality high if untreated, and even with treatment as 10-20%, further knowledge of immune response during scrub typhus needed. The current study was aimed at comparing plasma levels a variety inflammatory mediators patients controls South India order to map broader cytokine profile their relation disease severity clinical outcome.We examined several cytokines (n = 129) compared healthy 31) infectious...
Introduction Scandinavian countries have traditionally had a low prevalence of resistant organisms, but in recent years experienced change their epidemiology. We aim to describe the epidemiology carbapenemase-producing organisms (CPOs), vancomycin-resistant enterococci (VRE) and methicillin-resistant S. aureus (MRSA) Norway, measure importance infections contracted abroad, assess morbidity mortality associated with these bacteria Norway. Methods materials used data from Norwegian...
To assess the risk of transmission SARS-CoV-2 in schools Norway mainly kept open during covid-19 pandemic academic year 2020-21.Population wide, register based cohort study.Primary and lower secondary 2020-21, with strict infection prevention control measures place, such as organisation students into smaller cohorts. Contact tracing, quarantine, isolation were also implemented, testing staff identified close contacts.All educational primary Norway, from August 2020 to June 2021.Overall...
To compare effects of school closures with targeted infection prevention and control (IPC) measures in open schools on SARS-CoV-2 rates students.We conducted interrupted time-series analyses to trends grades 1-10 7 boroughs Oslo, Norway, between February 15 April 18, 2021. All at all levels had implemented strict IPC measures. While 1-4 attended throughout the study period, were for 5-10 from March 17. We obtained individual level data nationwide registries.A total 616, 452, 446 students...
Abstract Background Extensive measures to control spread of SARS-CoV-2 have led limited access education for millions children and adolescents during the COVID-19 pandemic. Education schools is vital adolescents’ learning, health, wellbeing. Based on high vaccine uptake low incidence levels, Nordic countries (Denmark, Finland, Iceland, Norway Sweden) decided start academic year 2021/22 with open in-person teaching moderate mitigation measures. We describe trends in infections vaccination...
The pathophysiological hallmark of spotted fever group rickettsioses comprises vascular inflammation. Based on the emerging importance wingless (Wnt) pathways in inflammation and biology, we hypothesized that Dickkopf-1 (DKK-1), as a major modulator Wnt signaling, could be involved pathogenesis rickettsial infections. Our findings were: (i) While baseline concentration DKK-1 patients with R. conorii infection (n = 32) were not different from levels controls 24), rose significantly...
Schools and preschools have largely remained open in Norway throughout the pandemic, with flexible mitigation measures place. This contrasts many other high-income countries that closed schools for long periods of time. Here we describe cases outbreaks COVID-19 during academic year 2020/2021, to evaluate strategy keeping these infection prevention control place.In this descriptive study, Norwegian Institute Public Health initiated systematic surveillance October 2020. Data was compiled from...
Based on their essential role in concerting immunological and inflammatory responses we hypothesized that the homeostatic chemokines CCL19 CCL21 may play a pathogenic rickettsiae infection.Serum levels of patients with R. africae conorii infection were analyzed by enzyme immunoassays. Lungs from infected mice examined for CCL19, CCR7 expression immunohistochemistry.We found (n = 15) particular those 16) had elevated serum admission, decline during follow-up. While similar pattern was seen...
Abstract Purpose The mechanisms that control inflammation in scrub typhus are not fully elucidated. Notch pathways important regulators of and infection, but have been investigated typhus. Methods Plasma levels the canonical ligand Delta-like protein 1 (DLL1) were measured by enzyme immunoassay RNA expression receptors ( NOTCH1 , NOTCH2 NOTCH4 ) whole blood was analyzed real-time PCR patients with n = 129), similar febrile illness without O. tsutsugamushi infection 31) healthy controls 31);...
Scrub typhus, caused by Orientia tsutsugamushi involves infiltration of a mixture perivascular lymphocytes and macrophages into affected organs. We investigated if this is characterized chemokine dysregulation.
Background The mechanisms that control local and systemic inflammation in scrub typhus have only been partially elucidated. wingless (Wnt) signaling pathways are emerging as important regulators of infection, but not investigated typhus. Methodology/Principal findings Plasma levels secreted Wnt antagonists (i.e. DKK-1, sFRP-3, WIF-1 SOST) were analyzed patients with (n = 129), similar febrile illness without O . tsutsugamushi infection 31), infectious disease controls, healthy controls 31)...
Objectives To assess transmission of SARS-CoV-2 in schools mainly kept open during the COVID-19 pandemic. Design Population-wide register-based cohort study. Setting Primary and lower secondary Norway have been academic year 2020/2021 with strict infection prevention control (IPC) measures place. All identified contacts including student staff members were urged to get tested following a positive case school. Participants students educational Norwegian primary from August 2020 June 2021....
Background Schools and preschools have largely remained open in Norway throughout the pandemic, with flexible mitigation measures place. This contrasts many other high-income countries that closed schools for long periods of time. Here we describe cases outbreaks COVID-19 during academic year 2020/2021, to evaluate strategy keeping these infection prevention control Methods In this descriptive study, Norwegian Institute Public Health initiated systematic surveillance October 2020. Data was...