A5085314086- Pituitary Gland Disorders and Treatments
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Growth Hormone and Insulin-like Growth Factors
- Birth, Development, and Health
- Tryptophan and brain disorders
- TGF-β signaling in diseases
- Ophthalmology and Eye Disorders
- Adrenal Hormones and Disorders
- MicroRNA in disease regulation
- Vector-borne infectious diseases
- Bone Metabolism and Diseases
- Reproductive System and Pregnancy
- Bariatric Surgery and Outcomes
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Inflammasome and immune disorders
- Gut microbiota and health
- Cardiac Fibrosis and Remodeling
- Wnt/β-catenin signaling in development and cancer
- Transplantation: Methods and Outcomes
- Clostridium difficile and Clostridium perfringens research
- Mosquito-borne diseases and control
- Alkaline Phosphatase Research Studies
- Pregnancy and Medication Impact
Oslo University Hospital
2016-2025
University of Oslo
2009-2020
GTx (United States)
2020
Posten (Norway)
2017
Tufts Medical Center
2015
Children's Specialized Hospital
2013
657 Oslo
2012
Karolinska Institutet
2009
Background Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically alternative complement pathway, is activated in patients with carotid atherosclerosis related adverse outcome these patients, are scarce. Methods Results We measured, by ELISA, plasma levels of factor D, properdin, C3bBbP (C3 convertase), H advanced a Discovery (n=324) Validation (n=206) cohort relation (mean follow‐up 7.8 6.6 years, respectively). Our major...
Objective— Based on the emerging importance of wingless (Wnt) pathways in inflammation and vascular biology, we hypothesized a role for Dickkopf-1 (DKK-1), major modulator Wnt signaling, atherogenesis plaque destabilization. Methods Results— We report increased levels DKK-1 experimental (ApoE −/− mice) clinical (patients with coronary artery disease [n=80] patients carotid [n=47]) atherosclerosis, both systemically (serum) within lesion, particularly high advanced unstable disease....
Context: Reduced expression of somatostatin receptors (SSTRs) in somatotroph adenomas and their potential down-regulation after medical treatment may explain the unsatisfactory response to octreotide particular acromegalic patients. The SSTRs other than SSTR2a has not been studied large, unselected cohorts using novel rabbit monoclonal antibodies. Objective: We aimed determine 1, 2a, 3, 5 adenomas, correlate with clinical characteristics octreotide, ascertain whether preoperative affected...
Although coronavirus disease 2019 (COVID-19) is primarily a respiratory infection, mounting evidence suggests that the gastrointestinal tract involved in disease, with gut barrier dysfunction and microbiota alterations being related to severity. Whether these persist are long-term remains unknown.Plasma was collected during hospital admission after 3 months from NOR-Solidarity trial (n = 181) analyzed for markers of inflammation. At 3-month follow-up, pulmonary function assessed by measuring...
Summary: Purpose: Long‐term treatment with antiepileptic drugs (AEDs) is associated increased risk of fractures. Phenytoin (PHT) and valproate (VPA) have both been suggested to influence bone health, whereas levetiracetam (LEV) scarcely studied. The present study compares the effect these AEDs on mass, biomechanical strength, turnover in rats. Methods: Female rats received PHT (50mg/kg), VPA (300mg/kg), or LEV (50 150mg/kg) for 90 days. Dissected femurs were analyzed using dual energy x‐ray...
Appropriate cell-to-cell adhesion is fundamental for the epithelial phenotype of pituitary cells. Loss protein E-cadherin has been associated with invasiveness, metastasis, and poor prognosis in cancers origin. In somatotroph adenomas, a variable reduced expression demonstrated. addition, nuclear translocation was found to correlate tumor invasion.The objective examine adenomas relation adenoma size, somatostatin analog (SMS) efficacy.Eighty-three patients were included, 29 treated...
Heart transplant (HTx) recipients usually have reduced exercise capacity with reported VO(2peak) levels of 50-70% predicted value. Our hypothesis was that high-intensity interval training (HIIT) is an applicable and safe form in HTx it would markedly improve VO(2peak.) Secondarily, we wanted to evaluate central peripheral mechanisms behind a potential increase. Forty-eight clinically stable >18 years old 1-8 after underwent maximal testing on treadmill were randomized either group (a 1-year...
A proinflammatory imbalance in the tumor necrosis factor (TNF) system may contribute to pathogenesis of schizophrenia (SCZ) and bipolar disorders (BDs) related comorbidities. We investigated relative distribution TNF-related molecules blood dorsolateral prefrontal cortex (DLPFC) these disorders. measured plasma levels TNF, soluble TNF receptor 1 (sTNFR1), 2 (sTNFR2), a disintegrin metalloprotease-17 (ADAM17) using enzyme immunoassays calculated TNF/sTNFRs ratio (TNF/sTNFR1+sTNFR2) sample 816...
Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that part of a psychosis continuum, dysregulated innate immune responses have been suggested to be involved in their pathophysiology. However, disease-specific mechanisms SMI not known yet. Recently, dyslipidemia has linked systemic inflammasome activation, elevated atherogenic lipid ratios shown correlate with circulating levels inflammatory biomarkers SMI. It is, however, yet if increased cholesterol load leads...
Toxoplasma gondii (TOXO) infection typically results in chronic latency due to its ability form cysts the brain and other organs. Latent toxoplasmosis could promote innate immune responses impact function. A large body of evidence has linked TOXO severe mental illness (SMI). We hypothesized that immunoglobulin G (IgG) seropositivity, reflecting previous current latency, is associated with increased circulating neuron-specific enolase (NSE), a marker damage, interleukin-18 (IL-18), an marker,...
Abstract Context: Fetuses exposed to an obese intrauterine environment are more likely be born large-for-gestational age (LGA) and at increased risk of obesity in childhood cardiovascular disease and/or type 2 diabetes mellitus as adults, but which factors that influence the is less clear. Objective: To investigate association between circulating levels leptin adiponectin, measured multiple times during pregnancy, birth weight prevalence LGA or small-for-gestational-age infants. The...
Gestational diabetes mellitus (GDM) is a significant risk factor for cardiovascular disease (CVD) in later life, but the mechanism remains unclear. Adipokine imbalance presence of metabolic dysfunction may be key event promoting CVD. The aim study was to examine relationships between GDM, risk, and plasma adiponectin, leptin leptin/adiponectin (L/A) ratio pregnancy at 5 years after index pregnancy.This population-based prospective cohort included 300 women who had an oral glucose tolerance...
Preeclampsia is associated with maternal metabolic disturbances, but longitudinal studies comprehensive profiling are lacking. We aimed to determine profiles across gestation in women who developed preeclampsia compared healthy pregnancies. also explored the respective effects of body mass index (BMI) and on various measures.We measured 91 metabolites by high-throughput nuclear magnetic resonance spectroscopy at four time points (visits) during pregnancy (weeks 14-16, 22-24, 30-32 36-38)....
Scrub typhus, caused by Orientia tsutsugamushi, is endemic in the Asia-Pacific region. Mortality high if untreated, and even with treatment as 10-20%, further knowledge of immune response during scrub typhus needed. The current study was aimed at comparing plasma levels a variety inflammatory mediators patients controls South India order to map broader cytokine profile their relation disease severity clinical outcome.We examined several cytokines (n = 129) compared healthy 31) infectious...
Gestational diabetes mellitus (GDM) is a significant risk factor for cardiovascular disease (CVD) in later life, but the mechanism remains unclear. The aim of study was to investigate indices glucose metabolism, dyslipidemia, and arterial stiffness (as measured by pulse wave velocity (PWV)), women with without history GDM, using both old WHO new IADPSG diagnostic criteria, at 5 years after index pregnancy. Dyslipidemia PWV were used as surrogate markers CVD risk. population-based prospective...
Abstract Common variable immunodeficiency (CVID) patients have reduced gut microbial diversity compared to healthy controls. The is associated with leakage, increased systemic inflammation and ten “key” bacteria that capture the dysbiosis (dysbiosis index) in CVID. Rifaximin a broad-spectrum non-absorbable antibiotic known reduce leakage (lipopolysaccharides, LPS) liver disease. In this study, we explored as ‘proof of concept’ altering composition could inflammation, using CVID disease...
The epithelial marker E-cadherin plays a crucial role in epithelial-mesenchymal transition (EMT). Decreased protein content somatotroph adenomas has been associated with increased tumor size, invasion, and poor response to somatostatin analog (SA) treatment, but the potential mechanisms of EMT progression these are lacking.We hypothesized that characterization EMT-related transcripts could identify novel therapeutic targets individuals SA treatment provide more knowledge mechanism...
Glucose intolerance in pregnancy predicts an increased risk of future type 2 diabetes.The aim the study was to evaluate glucose metabolism women with and without gestational diabetes mellitus (GDM) at 5 years follow-up identify factors associated disturbed post-partum.This included 300 consecutively enrolled from a previous population-based cohort study. The participants underwent oral tolerance test under study, addition dual-energy X-ray absorptiometry study.Fifty-two (17.7%) were found...
Background Maternal obesity is increasing worldwide but the consequences for maternal physiology and fetal growth are not fully understood. Objective To study whether changes in glucose lipid metabolism during pregnancy differ between women with normal weight overweight/obesity, investigate which of these metabolic factors associated birthweight. Design Prospective, longitudinal study. Setting Department Obstetrics, Oslo University Hospital, Rikshospitalet. Population 1031 healthy pregnant...
Preeclampsia, a hypertensive pregnancy disorder, links to increased long-term maternal cardiovascular disease (CVD). The risk is further with early-onset preeclampsia (EPE) and delivery of growth-restricted child. We hypothesized that circulating biomarkers associated CVD differed between subtypes controls. compared EPE; n=37, <week 34, late-onset (LPE); n=29, ≥week normotensive controls (n=49) using Olink Proseek multiplex I assay (targeting 92 biomarkers). stratified analysis...