A5081324908- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Gut microbiota and health
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Immunodeficiency and Autoimmune Disorders
- Liver Disease and Transplantation
- Clostridium difficile and Clostridium perfringens research
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Immune Cell Function and Interaction
- Systemic Sclerosis and Related Diseases
- HIV Research and Treatment
- Adolescent and Pediatric Healthcare
- Gastrointestinal motility and disorders
- Microscopic Colitis
- Diet and metabolism studies
- HIV-related health complications and treatments
- Dysphagia Assessment and Management
- Cancer Treatment and Pharmacology
- Immune responses and vaccinations
- Mycobacterium research and diagnosis
- Chemotherapy-induced cardiotoxicity and mitigation
- Drug Transport and Resistance Mechanisms
- Biliary and Gastrointestinal Fistulas
Oslo University Hospital
2015-2024
University of Oslo
2013-2023
<h3>Objective</h3> Gut microbiota could influence gut, as well hepatic and biliary immune responses. We therefore thoroughly characterised the gut in primary sclerosing cholangitis (PSC) compared with healthy controls (HC) patients ulcerative colitis without liver disease. <h3>Design</h3> prospectively collected 543 stool samples. After a stringent exclusion process, bacterial DNA was submitted for 16S rRNA gene sequencing. PSC HC were randomised to an exploration panel or validation panel,...
Common variable immunodeficiency (CVID) is the most common symptomatic primary characterized by low immunoglobulin (Ig)G and IgA, and/or IgM. In addition to bacterial infections, a large subgroup has noninfectious inflammatory autoimmune complications. We performed 16S ribosomal RNA-based profiling of stool samples in 44 CVID patients, 45 patients with bowel disease (disease controls), 263 healthy controls. measured plasma lipopolysaccharide (LPS) markers immune cell activation (i.e.,...
To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. We therefore aimed to characterize the genetic potential of gut PSC compared healthy controls (HCs) inflammatory bowel (IBD).Fecal DNA from 2 cohorts (1 Norwegian 1 German), total comprising 136 (58% IBD), 158 HCs, 93 IBD without PSC, were subjected metagenomic shotgun sequencing, generating...
Objective To compare faecal microbial composition in patients with systemic sclerosis (SSc) from 2 independent cohorts controls and to determine whether certain genera are associated SSc-gastrointestinal tract (GIT) symptoms. Design Adult SSc the University of California, Los Angeles (UCLA) Oslo Hospital (OUH) healthy participated this study (1:1:1). All participants provided stool specimens for 16S rRNA sequencing. Linear discriminant analysis effect size demonstrated differential...
Single-centre studies reported alterations of faecal microbiota in patients with primary sclerosing cholangitis (PSC). As regional factors may affect microbial communities, it is unclear if a signature PSC exists across different geographical regions.To identify robust independent geography and environmental influences.We included 388 individuals (median age, 47 years; range, 15-78) from Germany Norway the study, 137 (n = 75 colitis), 118 ulcerative colitis (UC) 133 healthy controls. Faecal...
Abstract Aims Recent reports have suggested that patients with heart failure (HF) an altered gut microbiota composition; however, associations diet remain largely uninvestigated. We aimed to explore differences in the between HF reduced ejection fraction and healthy controls, focusing on disease severity. Methods results The composition of two cross‐sectional cohorts (discovery, n = 40 validation, 44) systolic controls ( 266) was characterized by sequencing bacterial 16S rRNA gene. overall...
Objective Conflicting microbiota data exist for primary sclerosing cholangitis (PSC) and experimental models. Goal: define the function of complex resident microbes their association relevant to PSC patients by studying germ-free (GF) antibiotic-treated specific pathogen-free (SPF) multidrug-resistant 2 deficient ( mdr2 −/− ) mice microbial profiles in patient cohorts. Design We measured weights, liver enzymes, RNA expression, histological, immunohistochemical fibrotic biochemical...
Abstract Background & Aims One important hypothesis in primary sclerosing cholangitis pathophysiology suggests that bacterial products from an inflamed leaky gut lead to biliary inflammation. We aimed investigate whether circulating markers of translocation were associated with survival a Norwegian cohort. Methods Serum levels zonulin, intestinal fatty acid binding protein, soluble CD14, lipopolysaccharide and lipopolysaccharide‐binding protein measured 166 patients 100 healthy controls....
A substantial proportion of patients with common variable immunodeficiency (CVID) have inflammatory and autoimmune complications unknown etiology. We previously shown that systemic inflammation in CVID correlates their gut microbial dysbiosis. The microbiota dependent metabolite trimethylamine N-oxide (TMAO) has been linked to several metabolic disorders, but hitherto not investigated relation CVID. hypothesized TMAO is involved To explore this, we measured plasma concentrations TMAO,...
HIV infection and type 2 diabetes are associated with altered gut microbiota, chronic inflammation, increased cardiovascular risk. We aimed to investigate the combined effect of these diseases on microbiota composition related metabolites, a potential relation endothelial dysfunction in individuals HIV-infection only (n = 23), 16) or both conditions 21), as well controls 24). Fecal was analyzed by Illumina sequencing 16 S rRNA gene. Markers (asymmetric dimethylarginine [ADMA]), tryptophan...
Several characteristic features of the fecal microbiota have been described in primary sclerosing cholangitis (PSC), whereas data on mucosal are less consistent. We aimed to use a large colonoscopy cohort investigate key knowledge gaps, including role gut PSC with inflammatory bowel disease (IBD), effect liver transplantation (LT), and whether recurrent (rPSC) may be used define consistent irrespective LT.We included 84 51 transplanted patients (PSC-LT) 40 healthy controls (HCs) performed...
Abstract Common variable immunodeficiency (CVID) patients have reduced gut microbial diversity compared to healthy controls. The is associated with leakage, increased systemic inflammation and ten “key” bacteria that capture the dysbiosis (dysbiosis index) in CVID. Rifaximin a broad-spectrum non-absorbable antibiotic known reduce leakage (lipopolysaccharides, LPS) liver disease. In this study, we explored as ‘proof of concept’ altering composition could inflammation, using CVID disease...
Abstract The gut microbiome contributes to the variation of blood lipid levels, and secondary bile acids are associated with effect statins. Yet, our knowledge how statins, one most common drug groups, affect human is scarce. We aimed characterize rosuvastatin on composition inferred genetic content in stool samples from a randomized controlled trial ( n = 66). No taxa were significantly altered by during study. However, rosuvastatin-treated participants showed reduction collective potential...
Abstract Obesity-related diseases (e.g. type 2 diabetes mellitus and cardiovascular disorders) represent an increasing health problem worldwide. NLRP3 inflammasome activation may underlie obesity-induced inflammation insulin resistance, deficient mice exposed to high fat diet (HFD) appear be protected from left ventricle (LV) concentric remodeling. Herein, we investigated if these beneficial effects were associated with alterations in plasma metabolites, using metabolomic lipidomic analysis,...
Background Trimethylamine‐ N ‐oxide (TMAO) is produced in the liver from trimethylamine, which exclusively generated by gut bacteria. Objective The objective of this article to investigate relationship between TMAO and primary sclerosing cholangitis (PSC) its clinical characteristics. Methods Serum was measured 305 PSC patients, 90 ulcerative colitis patients 99 healthy controls. Results In with normal function ( n = 197), higher reaching transplantation or death during follow‐up than those...
Abstract Background Human immunodeficiency virus (HIV)–infected immunological nonresponders (INRs) fail to reconstitute their CD4+ T-cell pool after initiation of antiretroviral therapy, and prognosis is inferior that responders (IRs). A prevailing hypothesis the INR phenotype caused by a persistently disrupted mucosal barrier, but assessments gut immunology in different anatomical compartments are scarce. Methods We investigated circulating markers dysfunction, immune activation, Th17 Th22...