A5065909814- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Adrenal and Paraganglionic Tumors
- Parathyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- Ophthalmology and Eye Disorders
- Glioma Diagnosis and Treatment
- Astronomical Observations and Instrumentation
- TGF-β signaling in diseases
- Pancreatic and Hepatic Oncology Research
- Thyroid and Parathyroid Surgery
- Bone health and osteoporosis research
- Bone health and treatments
- Neuroendocrine Tumor Research Advances
- Photodynamic Therapy Research Studies
- Cerebrospinal fluid and hydrocephalus
- Nanoplatforms for cancer theranostics
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Hypoxia, and Metabolism
- Pancreatitis Pathology and Treatment
- Astronomy and Astrophysical Research
- Myasthenia Gravis and Thymoma
- Cancer Immunotherapy and Biomarkers
- Vitamin D Research Studies
- Thyroid Cancer Diagnosis and Treatment
Oslo University Hospital
2016-2025
University of Oslo
2015-2024
Manchester University NHS Foundation Trust
2019
Children's Specialized Hospital
2013
Akershus University Hospital
2007
Medizinisches Laserzentrum Lübeck (Germany)
1994
This European expert consensus statement provides recommendations for the diagnosis and management of primary hyperparathyroidism (PHPT), chronic hypoparathyroidism in adults (HypoPT), parathyroid disorders relation to pregnancy lactation. Specified areas interest unmet needs identified by experts at second ESE Educational Program Parathyroid Disorders (PARAT) 2019, were discussed during two virtual workshops 2021, subsequently developed working groups with specified areas. PHPT is a common...
Summary Context Somatotroph adenomas have been classified into densely granulated (DG) and sparsely (SG) tumours with a transitional, intermediate group. Gsp oncogenes are activating mutations in the Gsα subunit gene, found approximately 40% of somatotroph adenomas. Objectives To explore granulation pattern presence gsp oncogene acromegaly correlations to clinical biochemical variables effect treatment somatostatin analogues (SA), as well describe without SA pretreatment....
Primary, preoperative medical treatment is an option in selected patients with acromegaly, but a subset of respond poorly. Valid prediction response to somatostatin analogues (SA) might thus alter stratification. The aims this study were assess whether T2 signal intensity could determine long-term first-line SA and clinical biochemical baseline characteristics, as well histological subtype relation the magnetic resonance imaging (MRI) appearances.In 45 newly diagnosed patients, T2-weighted...
Context: Reduced expression of somatostatin receptors (SSTRs) in somatotroph adenomas and their potential down-regulation after medical treatment may explain the unsatisfactory response to octreotide particular acromegalic patients. The SSTRs other than SSTR2a has not been studied large, unselected cohorts using novel rabbit monoclonal antibodies. Objective: We aimed determine 1, 2a, 3, 5 adenomas, correlate with clinical characteristics octreotide, ascertain whether preoperative affected...
Mild primary hyperparathyroidism (PHPT) is a common disease especially in middle-aged and elderly women. The diagnosis frequently made incidentally treatment strategies are widely discussed. To study the effect of parathyroidectomy (PTX) compared with observation (OBS) on biochemistry, safety, bone mineral density (BMD), new fractures. Prospective, randomized controlled (SIPH study), 5-year follow-up. was conducted at multicenter, tertiary referral centers. Of 191 patients mild PHPT,...
Mild primary hyperparathyroidism (PHPT) is known to affect the skeleton, even though patients usually are asymptomatic. Treatment strategies have been widely discussed. However, long-term randomized studies comparing parathyroidectomy observation lacking. The objective was study effect of (PTX) compared with (OBS) on bone mineral density (BMD) in g/cm2 and T-scores biochemical markers turnover (P1NP CTX-1) a prospective controlled mild PHPT after 5 years follow-up. Of 191 either PTX or OBS,...
Insulin resistance and dysglycemia are associated with physical inactivity adiposity, may be improved by exercise.Investigate the effect of exercise on insulin sensitivity, body composition adipose depots in sedentary men (n = 11) or without overweight dysglycemia.Euglycemic-hyperinsulinemic clamp, ankle-to-neck MRI, MRS, muscle tissue biopsies before after 12 weeks combined strength endurance exercise.Insulin VO2max, strength, whole-body fat content, abdominal were obvious differences...
Primary hyperparathyroidism (PHPT) is a common endocrine disorder associated with increased risk for fractures, cardiovascular disease, kidney and cancer mortality. In mild PHPT modest hypercalcemia without known morbidities, parathyroidectomy (PTX) debated because no long-term randomized trials have been performed.To examine the effect of PTX on regard to mortality (primary end point) key morbidities (secondary point).Prospective controlled trial. (ClinicalTrials.gov: NCT00522028).Eight...
Bone turnover is increased in acromegaly. Despite normalization of bone after treatment, the risk for vertebral fractures remains increased. Gonadal status, but not BMD, correlated with fractures. Trabecular score (TBS) related to microarchitecture.The aim this study assess longitudinal change TBS and BMD following treatment DESIGN, SETTING, PATIENTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: This included 48 patients acromegaly between 2005 2015. TBS, markers (P1NP CTX-1) were measured at...
ABSTRACT Primary hyperparathyroidism (PHPT) was previously considered a disease presenting with multiorgan involvement and wide range of symptoms. Today, the presents no symptoms or mild symptomatology in most patients. Data regarding nonspecific such as pain, fatigue, memory loss, depression, other neuropsychiatric signs have been ambiguous, results from prospective long-term randomized control trials are lacking. The Scandinavian Investigation on Hyperparathyroidism (SIPH) is controlled...
ABSTRACT Mild or asymptomatic disease is now the dominating presentation of primary hyperparathyroidism (PHPT). However, bone involvement with decreased mineral density (BMD) and an increased risk fractures has been demonstrated. Indications for parathyroidectomy (PTX) in mild PHPT have debated years. There a need long‐term randomized studies comparing PTX observation without intervention (OBS). Here, we present health data from Scandinavian Investigation Primary Hyperparathyroidism (SIPH),...
Abstract Background and purpose In acromegaly, growth hormone (GH) excess pituitary tumours are typically managed through transsphenoidal surgery, often in combination with somatostatin receptor ligands (SRLs) given either before or following surgery. Although first-generation SRLs (lanreotide octreotide) efficacious many patients, some exhibit resistance. Methods We present the efficacy of second-generation SRL, pasireotide, six patients anticipated to be resistant SRLs. The had large,...
<b><i>Background/Aims:</i></b> Adipose tissue (AT) distribution is closely related to metabolic disease risk. Growth hormone (GH) reduces visceral and total body fat mass induces whole-body insulin resistance. Our aim was assess the effects of AT (VAT) derived adipokines on systemic resistance lipid metabolism in acromegaly. <b><i>Methods:</i></b> Seventy adult patients with active acromegaly (43 males, age 49 ± 14 years) were evaluated before...
Abstract Background Cushing’s syndrome (CS) is associated with an hypercoagulable state and increased risk of venous thromboembolism (VTE). Evidence-based guidelines on thromboprophylaxis strategies in patients CS are currently lacking. We aimed to map the current clinical practice for management across reference centers (RCs) European Reference Network Rare Endocrine Conditions (Endo-ERN), which endorsed specifically diagnosis treatment CS. Using EU survey tool, a primary screening survey,...
Somatostatin analogs (SA) have been established as the first line medical treatment for acromegaly, but following long-term treatment, SA normalizes GH and IGF-I levels in only 40-60% of patients. The epithelial marker E-cadherin plays a crucial role mesenchymal transition (EMT) is associated with poor response to treatment. We hypothesized that characterization transcripts regulated by somatotroph adenomas high low expression may identify signaling pathways mediators can explain performed...
Mild primary hyperparathyroidism has been associated with increased body fat mass and unfavorable cardiovascular risk factors.To assess the effect of parathyroidectomy on mass, glucose lipid metabolism.119 patients previously randomized to observation (OBS; n = 58) or (PTX; 61) within Scandinavian Investigation Primary Hyperparathyroidism (SIPH) trial, an open multicenter study, were included. Main outcome measures for this study differences in markers metabolism between OBS PTX 5 years...
Recent data have shown a decreasing overall mortality in acromegaly over the last decades. However, cancer incidence and cancer-related still appear to be increased. Our aim was obtain updated epidemiological from Norway clinically well-defined cohort with complete register-based follow-up.Patients diagnosed South-Eastern between 1999-2019 (n = 262) age sex matched population controls (1:100) were included 26,200). Mortality obtained Norwegian Cause of Death Cancer Registry. compared by...
Abstract Objective Active acromegaly is subject to sex differences in growth hormone (GH) and Insulin like factor 1 (IGF‐I) patterns as well clinical features but whether this also pertains controlled disease unclear. Design In a cross‐sectional, multi‐centre study, 84 patients with ( F = 43, M 41), who were considered after surgery alone n 23) or during continued somatostatin receptor ligand (SRL) treatment 61), examined. Methods Serum concentrations of GH, insulin, glucose free fatty acid...
Discordant GH and IGF-I values are frequent in acromegaly. The clinical significance its dependence on treatment modality of glucose-suppressed (GHnadir) measurements remain uncertain.To evaluate the effects targeting either or during somatostatin analogue (SA) treatment.84 patients with controlled acromegaly after surgery (n = 23) SA 61) underwent a profile including an OGTT, at baseline 12 months. were randomized to monitoring according 33) GHnadir 28). dose escalation was allowed 6...