A5003031707- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Neural dynamics and brain function
- Genetic Associations and Epidemiology
- Immune Response and Inflammation
- Child and Adolescent Psychosocial and Emotional Development
- Functional Brain Connectivity Studies
- Cystic Fibrosis Research Advances
- Bacterial biofilms and quorum sensing
- Pharmacovigilance and Adverse Drug Reactions
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Child Abuse and Trauma
- Diet and metabolism studies
- Antibiotic Resistance in Bacteria
- Youth Substance Use and School Attendance
- Stress Responses and Cortisol
- COVID-19 Clinical Research Studies
- Neuroscience and Music Perception
- Obsessive-Compulsive Spectrum Disorders
- Clinical Reasoning and Diagnostic Skills
- Regulation of Appetite and Obesity
- Genetics, Aging, and Longevity in Model Organisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Oslo University Hospital
2020-2024
University of Oslo
2020-2024
University Hospital Regensburg
2018-2024
Weatherford College
2024
University of Regensburg
2015-2021
Institute of Medical Microbiology and Hygiene
2015-2020
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic challenges national health systems and the global economy. Monitoring of infection rates seroprevalence can guide public measures to combat pandemic. This depends on reliable tests active former infections. Here, we set out develop validate a specific sensitive enzyme linked immunosorbent assay (ELISA) for detection anti-SARS-CoV-2 antibody levels.In our ELISA, used SARS-CoV-2 receptor-binding domain (RBD) stabilized...
Abstract Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) increases the risk of cardiovascular disease (CVD). However, mechanisms underlying relationship between loneliness, SMDs, CVD factors remain unknown. Here we explored overlapping genetic architecture loci shared factors. We analyzed large independent genome-wide association study data on schizophrenia (SCZ), bipolar disorder (BD), major depression (MD), using bivariate...
Abstract Several lines of evidence implicate immune abnormalities in the pathophysiology severe mental disorders (SMD) and comorbid disorders. Here, we use data from genome-wide association studies (GWAS) autoimmune diseases phenotypes associated with SMD to disentangle genetic susceptibilities SMD. We included 1004 patients 947 healthy controls (HC) measured plasma levels IL-1Ra, sIL-2R, gp130, sTNFR-1, IL-18, APRIL, ICAM-1. Polygenic risk scores (PRS) six disorders, CRP, 10 SMD-related...
Adequate perception of immunologically important pathogen-associated molecular patterns like lipopolysaccharide and bacterial lipoproteins is essential for efficient innate adaptive immune responses. In the context Gram-negative infection, bactericidal/permeability-increasing protein (BPI) neutralizes endotoxic activity lipopolysaccharides, thus prohibits hyperactivation. So far, no immunological function BPI has been described in Gram-positive infections. Here we show a significant...
Low-grade inflammation has been implicated in the pathophysiology of severe mental disorders (SMDs) and a link between immune activation clinical characteristics is suggested. However, few studies have investigated how patterns across markers are related to diagnosis illness course.
Impulsivity is a transdiagnostic feature linked to severe clinical expression and potential target for psychopharmacological strategies. Biological underpinnings are largely unknown, but involvement of immune dysregulation has been indicated, the effects agents vary. We investigated if impulsivity was associated with circulating marker levels range treatment regimens in mental disorders.Impulsivity assessed sample (N = 657) patients schizophrenia or schizophreniform disorder (SCZ) 116)...
Low-grade inflammation may be part of the underlying mechanism schizophrenia and bipolar disorder. We investigated if genetic susceptibility, infections or autoimmunity could explain immune activation. Seven markers were selected based on indicated associations to severe mental disorders (IL-1Ra, sIL-2R, IL-18, sgp130, sTNFR-1, APRIL, ICAM-1) measured in plasma patients with (SCZ, N = 732) spectrum (BD, 460) healthy controls (HC, 938). Information rate autoimmune diseases obtained from...
Gram-negative sepsis driven by lipopolysaccharide (LPS) has detrimental outcomes, especially in neonates. The neutrophil-derived bactericidal/permeability-increasing protein (BPI) potently neutralizes LPS. Interestingly, polymorphism of the BPI gene at position 645 (rs4358188) corresponds to a favorable survival rate these patients presence least one allele A as opposed G. When we exploited existing X-ray crystal structure, corresponding amino acid 216 was revealed surface exposed and...
Agitation is a challenging clinical feature in severe mental disorders, but its biological correlates are largely unknown. Inflammasome-related abnormalities have been linked to disorders and implicated animal models of agitation. We investigated if levels circulating inflammasome-related immune markers were associated with agitation disorders.Individuals psychotic or affective disorder (N = 660) underwent blood sampling characterization. Plasma interleukin (IL)-18, IL-18 binding protein...
Neutrophil-derived bactericidal/permeability-increasing protein (BPI) is known for its bactericidal activity against gram-negative bacteria and neutralization of lipopolysaccharide. Here, we define BPI as a potent activator murine dendritic cells (DCs). As shown in GM-CSF-cultured, bone-marrow-derived (BMDCs), induces distinct stimulation profile including IL-2, IL-6, tumor necrosis factor expression. Conventional DCs also respond to BPI, while M-CSF-cultivated or peritoneal lavage...
Individuals with schizophrenia and bipolar disorder are at an increased risk of cardiovascular disease (CVD), a range biomarkers related to CVD have been found be abnormal in these patients. Common genetic factors putative underlying mechanism, alongside lifestyle antipsychotic medication. However, the extent which altered involved is unknown. In sample including 699 patients schizophrenia, 391 disorder, 822 healthy controls, we evaluated 8 biomarkers, BMI, fasting plasma levels from...
Classical and plasmacytoid dendritic cells (DC) play important roles in the defense against murine human infections with herpes simplex virus (HSV). So far, CD8α expression has only been reported for DC. CD8α(+) DC have prominent cross-presenting activities, which are enhanced by PDC. The orthologue of DC, CD141 (BDCA3)(+) mainly cross-present after TLR3 ligation. We report here serendipitous finding that a subset PDC upregulates upon HSV-1 stimulation, as shown gene array flow cytometry...
Chronic pulmonary infection is a hallmark of cystic fibrosis (CF) and requires continuous antibiotic treatment. In this context, Pseudomonas aeruginosa ( Pa ) special concern since colonizing strains frequently acquire multiple drug resistance (MDR). Bactericidal/permeability-increasing protein (BPI) neutrophil-derived, endogenous with high bactericidal potency against Gram-negative bacteria. However, significant range people CF (PwCF) produce anti-neutrophil cytoplasmic antibodies BPI...
People with severe mental disorders (SMDs) show an increased prevalence of tobacco smoking compared to the general population. Tobacco and other adult adverse health behaviors have been associated traumatic experiences in childhood. In present study we investigated relationship between childhood trauma people SMDs, including possible mediating role cognitive- personality characteristics, i.e. cognitive control, impulsiveness, affective lability self-esteem. Enrolled were 871 participants...
Serological testing is crucial in detection of previous infection and monitoring convalescent vaccine-induced immunity. During the Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) pandemic, numerous assay platforms have been developed marketed for clinical use. Several studies recently compared performance a limited number serological tests, but broad comparative evaluation currently missing. Within this study, panel 161 sera from SARS-CoV-2 infected, seasonal CoV-infected naïve...
Abstract Background Cardiometabolic risk is increased in severe mental disorders (SMDs), and there appears to be a relationship between childhood trauma cardiometabolic risk, possibly related adverse health behavior. The current study examined the association serum lipids adiposity SMDs potential mediating role of cognitive personality characteristics. Methods Participants with schizophrenia bipolar spectrum ( N = 819) were included, factors , body mass index waist circumference) measured,...
Background: Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) associated with elevated cardiovascular disease (CVD) risk, including obesity. Leptin adiponectin secreted by adipose tissue, pro- anti-inflammatory properties, respectively. The second generation antipsychotics (AP) olanzapine, clozapine, quetiapine have been high leptin levels in SMI. However, the link between inflammatory dysregulation of CVD risk SMI, how this is influenced body mass AP...
Abstract Objective Low total cholesterol has been linked with adverse mental symptoms such as aggression and impulsivity in severe disorders (SMDs). This putative association may affect the clinician's decision making about lowering this patient group. Here, we investigated associations between levels, aggression, a large representative sample of in‐ outpatients SMD. Methods Patients schizophrenia‐ or bipolar spectrum ( N = 1 001) underwent thorough clinical characterization blood sampling...
BAKGRUNN Pasienter i Norge har siden 1. mars 2010 hatt mulighet til å melde bivirkninger Statens legemiddelverk. Formålet med denne studien var kartlegge disse bivirkningsmeldingene. MATERIALE OG METODE Innholdet bivirkningsmeldinger mottatt fra pasienter perioden og 31. desember 2013 ble klassifisert ut alder, kjønn, mistenkt legemiddel bivirkning. Deretter funnene pasientmeldingene sammenliknet helsepersonell samme tidsperiode. RESULTATER I den aktuelle tidsperioden det 755 meldinger 9 629...
Adverse effects of antipsychotics (AP) contribute to cardiovascular disease (CVD) risk in patients with severe mental disorders (SMD). We investigated sex differences AP-related CVD factors and the role metabolic hormones.Patients SMD (N = 1791) receiving AP different were recruited grouped into olanzapine and/or clozapine 532), other APs 744) or no use 515). Associations between factor (total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density (LDL-C), triglycerides (TG),...
Abstract Background and Hypothesis The auditory cortex (AC) may play a central role in the pathophysiology of schizophrenia hallucinations (AH). Previous studies report thinner AC impaired function, as indicated by decreased N100 amplitude evoked potential. However, whether these structural functional alterations link to AH remain poorly understood. Study Design Patients with spectrum disorder (SCZspect), including patients lifetime experience (AH+), without (AH−), healthy controls underwent...