A5033363764- Orthopedic Infections and Treatments
- Intestinal and Peritoneal Adhesions
- Surgical Sutures and Adhesives
- Hernia repair and management
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 Clinical Research Studies
- Cystic Fibrosis Research Advances
- Long-Term Effects of COVID-19
- Tissue Engineering and Regenerative Medicine
- SARS-CoV-2 and COVID-19 Research
- Ethics in Clinical Research
- Cardiac electrophysiology and arrhythmias
- Cancer Research and Treatments
- Wound Healing and Treatments
- Tendon Structure and Treatment
- Peripheral Artery Disease Management
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Osteomyelitis and Bone Disorders Research
- Bone fractures and treatments
- Infective Endocarditis Diagnosis and Management
- 3D Printing in Biomedical Research
University Medical Centre Mannheim
2023-2025
Heidelberg University
2014-2025
University Hospital Heidelberg
2014-2025
University of Regensburg
2017-2024
University Hospital Regensburg
2017-2024
Heidelberg University
2024
Medizinische Fakultät Mannheim
2024
University Medical Center
2013-2024
University of Mannheim
2024
Johannes Gutenberg University Mainz
2010-2021
Interleukin (IL)-17A is regarded as an important cytokine to drive psoriasis, inflammatory skin disease marked by increased cardiovascular mortality. We aimed test the hypothesis that overproduction of IL-17A in leading dermal inflammation may systemically cause vascular dysfunction psoriasis-like disease.Conditional overexpression keratinocytes caused severe mice (K14-IL-17A(ind/+) mice), associated with reactive oxygen species formation and circulating CD11b(+) leukocytes blood,...
Recently, we demonstrated that gene ablation of mitochondrial manganese superoxide dismutase and aldehyde dehydrogenase-2 markedly contributed to age-related vascular dysfunction oxidative stress. The present study has sought investigate the extent oxidant formation in glutathione peroxidase-1–deficient ( GPx-1 −/− ) mice during aging process with special emphasis on dysregulation (uncoupling) endothelial NO synthase. a C57 black 6 (C57BL/6) background at 2, 6, 12 months age were used....
Primary ciliary dyskinesia (PCD) is a heterogeneous genetic condition. European and North American diagnostic guidelines recommend transmission electron microscopy (TEM) as one of combination tests to confirm diagnosis. However, there no definition what constitutes defect or consensus on reporting terminology. The aim this project was provide an internationally agreed ultrastructural classification for PCD diagnosis by TEM. A guideline developed experts representing 18 centres in 14...
The potential toxicity of nanoparticles has currently provoked public and scientific discussions, attempts to develop generally accepted handling procedures for are under way. investigation the impact on human health is overdue reliable test systems accounting special properties nanomaterials must be developed. Nanoparticular zinc oxide (ZnO) may internalised through ambient air or topical application cosmetics, only name a few, with unpredictable effects. Therefore, we analysed determinants...
Curcumin has anti-inflammatory effects and qualifies as a potential candidate for the treatment of osteoarthritis (OA). However, curcumin limited bioavailability. Extracellular vesicles (EVs) are released by multiple cell types act molecule carrier during intercellular communication. We assume that EVs can maintain bioavailability stability after encapsulation. Here, we evaluated modulatory curcumin-primed human (h)BMSC-derived (Cur-EVs) on IL-1β stimulated osteoarthritic chondrocytes...
Atrial fibrillation (AF) and heart failure often coexist, but their interaction is poorly understood. Clinical data indicate that the arrhythmic component of AF may contribute to left ventricular (LV) dysfunction. This study investigates effects molecular mechanisms on human LV. Ventricular myocardium from patients with aortic stenosis preserved LV function sinus rhythm or rate-controlled was studied. showed no differences in fibrosis. In functional studies, systolic Ca2+ transient amplitude...
Fracture-related infection (FRI) is a major complication in orthopedic and trauma surgery. The management choice of treatment can be difficult depending on multiple factors. Therefore, we implemented weekly multidisciplinary team discussion to determine diagnostic strategies FRI patients aimed analyze its effect clinical outcomes.Clinical outcomes treated before after implementation structured (MDT) approach with case were compared at follow-up 12 months.In total, n = 117 eligible for...
In Brief Background The human regulatory macrophage (Mreg) has emerged as a promising cell type for use cell-based adjunct immunosuppressive therapy in solid organ transplant recipients. this brief report, dehydrogenase/reductase 9 (DHRS9) is identified robust marker of Mregs. Methods cognate antigen mouse monoclonal antibody raised against Mregs was DHRS9 by immunoprecipitation and MALDI-MS sequencing. Expression within panel monocyte-derived macrophages investigated quantitative PCR,...
After many years of controversy, there is now recent and solid evidence that classical Borna disease virus 1 (BoDV-1) can infect humans. On the basis six brain autopsies, we provide first systematic overview on BoDV-1 tissue distribution lesion pattern in fatal BoDV-1-induced encephalitis. All brains revealed a non-purulent, lymphocytic sclerosing panencephalomyelitis with detection BoDV-1-typical eosinophilic, spherical intranuclear Joest–Degen inclusion bodies. While composition...
The poor healing capacity of tendons is known to worsen in the elderly. During tendon aging and degeneration, endogenous human stem/progenitor cells (hTSPCs) experience profound pathological changes. Here, we explored a rejuvenation strategy for hTSPCs derived from aged/degenerated Achilles (A-TSPCs) by providing three-dimensional (3D) nanofiber hydrogels comparing them young/healthy TSPCs (Y-TSPCs). RADA peptide hydrogel has self-assembling ability, forms nanofibrous 3D niche can be further...
In 2019, the EPMA celebrated its 10th anniversary at 5th World Congress in Pilsen, Czech Republic. The history of International Professional Network dedicated to Predictive, Preventive and Personalised Medicine (PPPM / 3PM) is rich achievements. Facing coronavirus COVID-19 pandemic it getting evident globally that predictive approach, targeted prevention personalisation medical services optimal paradigm healthcare demonstrating high potential save lives benefit society as a whole. Supplement...
Abstract Between April and June 2020, i.e., during the first wave of pandemic coronavirus disease 2019 (COVID-19), 55 patients underwent long-term treatment in intensive care unit at University Hospital Regensburg. Most them were transferred from smaller hospitals, often due to need for an extracorporeal membrane oxygenation system. Autopsy was performed 8/17 COVID-19-proven after (mean: 33.6 days). revealed that typical pathological changes occurring early stages (e.g., thrombosis,...
One of the most important complications heart transplantation is organ rejection, which diagnosed on endomyocardial biopsies by pathologists. Computer-based systems could assist in diagnostic process and potentially improve reproducibility. Here, we evaluated feasibility using deep learning predicting degree cellular rejection from pathology slides as defined International Society for Heart Lung Transplantation (ISHLT) grading system.
Fracture-related infection (FRI) is a devastating complication in orthopedic surgery. A recent study showed that FRI causes more severe and further delays healing osteoporotic bone. Moreover, bacterial biofilm formed on implants cannot be eradicated by systemic antibiotics, warranting novel treatments. Here, we developed DNase I Vancomycin hydrogel delivery vehicle to eradicate Methicillin-resistant Staphylococcus aureus (MRSA) vivo. was encapsulated liposomes,...
Survivin is described as a bifunctional protein inhibiting apoptosis and regulating mitosis. However, the biological functions contributions to cancer progression of survivin splice variants are controversially discussed. We here show that intracellular localization these depends on Crm1-dependent nuclear export signal (NES) present in survivin, surviving(-2B) survivin(-3B), but absent survivin(-deltaEx3) survivin(-2alpha). isoforms lack an active import able enter nucleus by passive...
We recently demonstrated that a blunt chest trauma, strong inducer of the posttraumatic systemic inflammatory response and one most critical injuries in polytrauma patients, significantly delayed fracture healing rats, possibly by interaction inflammation with early regeneration processes locally at site. The underlying cellular mechanisms, however, have as yet remained unknown. Therefore, aim this study was to analyze morphologic composition callus after trauma.Rats received an osteotomy...