A5061882106- Cellular Mechanics and Interactions
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Force Microscopy Techniques and Applications
- Tendon Structure and Treatment
- Spectroscopy Techniques in Biomedical and Chemical Research
- Optical Coherence Tomography Applications
- Shoulder Injury and Treatment
- Laser Applications in Dentistry and Medicine
- Lipid Membrane Structure and Behavior
- Nanofabrication and Lithography Techniques
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced Fluorescence Microscopy Techniques
- Veterinary Equine Medical Research
- Metal and Thin Film Mechanics
- Photoacoustic and Ultrasonic Imaging
- Microfluidic and Bio-sensing Technologies
- Knee injuries and reconstruction techniques
- Diamond and Carbon-based Materials Research
- Bone Tissue Engineering Materials
- Caveolin-1 and cellular processes
- Polymer Surface Interaction Studies
- Cell Adhesion Molecules Research
- Bone fractures and treatments
- RNA Interference and Gene Delivery
Ludwig-Maximilians-Universität München
2019-2021
Center for NanoScience
2019-2021
Munich University of Applied Sciences
2019-2021
The poor healing capacity of tendons is known to worsen in the elderly. During tendon aging and degeneration, endogenous human stem/progenitor cells (hTSPCs) experience profound pathological changes. Here, we explored a rejuvenation strategy for hTSPCs derived from aged/degenerated Achilles (A-TSPCs) by providing three-dimensional (3D) nanofiber hydrogels comparing them young/healthy TSPCs (Y-TSPCs). RADA peptide hydrogel has self-assembling ability, forms nanofibrous 3D niche can be further...
Tendon stem/progenitor cells (TSPC) are potential targets for regenerative medicine and the treatment of tendon injuries. The frequency such injuries increases in elderly patients while proportion functional TSPCs tissue decreases, protracting repair. Using atomic force microscopy (AFM), we show that cell stiffness size increase isolated from (A-TSPC) compared to younger (Y-TSPC). Additionally, two-photon excited fluorescence (TPEF) revealed a denser, well-structured actin cytoskeleton...
Intranasal drug delivery is a promising approach for the of drugs to CNS, but too heterogenous, unprecise methods without standardization decrease quality many studies in rodents. Thus, lack precise and region-specific application technique mice major drawback. In this study, previously developed catheter-based refined was validated against conventional pipette-based method used specifically reach olfactory or respiratory nasal regions. This study successfully demonstrated administration at...
Abstract Following biomaterial implantation, a failure to resolve inflammation during the formation of fracture hematoma can significantly limit biomaterial's ability facilitate bone regeneration. This study aims combine immunomodulatory and osteogenic effects BMP‐7 IL‐10 with regenerative capacity collagen‐hydroxyapatite (CHA) scaffolds enhance in vitro mineralization hematoma‐like environment. Incubation CHA human whole blood leads rapid adsorption fibrinogen, significant stiffening...
Hyaluronan (HA), a natural component of the extracellular matrix, is supposed to have regulatory function in stem cell niche. Bone marrow-derived human mesenchymal cells (hMSCs) are known express all three hyaluronan synthases (HASes), which responsible for HA production. extruded into but also stays bound plasma membrane forming pericellular coat, plays key role during early adhesion. Since HAS isoenzymes, HAS1, HAS2 and HAS3, produce with different molecular weights, difference their...
The utilization of lasers in dentistry expands greatly recent years. For instance, fs-lasers are effective for both drilling and caries prevention, while cw-lasers useful adhesive hardening. A cutting-edge application is the debonding veneers. While there pre-existing tools this purpose, still potential improvement. Initial efforts to investigate laser assisted mechanisms with measurements optical mechanical properties teeth prosthetic ceramics presented. Preliminary tests conducted a system...
Abstract: The Prospective Instruments MPX-series is a turnkey compact multimodal microscope enabling advanced multiphoton imaging without requiring laboratory or optical bench. One of the key design features ultrafast fiber laser engine integrated into free moving scan head, which lightweight, rugged, and allows ultimate flexibility. A modular concept user to explore wide variety biological applications measurements, compromising performance, in any indoor working space. In contrast,...
Abstract The sample preparation and, in certain cases, the nanoindenter itself have an impact on measurement results of a nanoindentation process electropolished aluminum surfaces. In this work, indentation hardness and modulus recrystallized ultra-pure were determined. To end, surfaces prepared by electrolysis. Two sources influence investigated respectively: (roughness deformed layer) (influence edge damage to caused measuring head). Very smooth ( R < 1 nm) could be generated. A...