A5076631839- COVID-19 Clinical Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Sulfur Compounds in Biology
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Birth, Development, and Health
- Tuberculosis Research and Epidemiology
- Advanced Glycation End Products research
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Circular RNAs in diseases
- Sepsis Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Pregnancy and preeclampsia studies
- RNA Research and Splicing
- Intensive Care Unit Cognitive Disorders
- Hematological disorders and diagnostics
- Clinical Nutrition and Gastroenterology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Microbial Metabolism and Applications
- Biochemical effects in animals
- Ferroptosis and cancer prognosis
- melanin and skin pigmentation
- Geophysical Methods and Applications
Fudan University
2008-2025
Guiyang Medical University
2019-2024
Affiliated Hospital of Guizhou Medical University
2024
Huadong Hospital
2020-2023
Tsinghua University
2023
Tongji Hospital
2013-2021
Tongji University
2021
University Medical Center of the Johannes Gutenberg University Mainz
2013-2020
Johannes Gutenberg University Mainz
2013-2020
Huashan Hospital
2013-2020
Interleukin (IL)-17A is regarded as an important cytokine to drive psoriasis, inflammatory skin disease marked by increased cardiovascular mortality. We aimed test the hypothesis that overproduction of IL-17A in leading dermal inflammation may systemically cause vascular dysfunction psoriasis-like disease.Conditional overexpression keratinocytes caused severe mice (K14-IL-17A(ind/+) mice), associated with reactive oxygen species formation and circulating CD11b(+) leukocytes blood,...
Since December 2019, an outbreak of Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) initially emerged in Wuhan, China, and has spread worldwide now. Clinical features patients with COVID-19 have been described. However, risk factors leading to in-hospital deterioration poor prognosis not well identified. In this retrospective, single-center cohort study, 1190 adult inpatients (≥ 18 years old) laboratory-confirmed determined...
Abstract Background Systemic reactivation of Epstein–Barr virus (EBV) may occur in novel coronavirus disease 2019 (COVID‐19) caused by the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). However, clinical consequences EBV remain uncertain. Methods In this retrospective study, we screened 1314 patients with confirmed COVID‐19 who died or were discharged between January 1, 2020 and March 12, 2020, Wuhan Infectious Disease Hospital, Wuhan, China. Patients had complete data for...
Introduction Human serum albumin (HSA) is a non-glycosylated, negatively charged, single-chain polypeptide composed of 585 amino acid residues with relative molecular mass 66.438 kD. It synthesized by the liver at rate approximately 200 mg·kg−1·day−1, half-life 21 days, and subjected to catabolism in muscles, liver, kidneys 4% per day.[1] Albumin, accounting for 60% total plasma protein, has various physiological functions,[2] such as maintaining 70% 80% effective colloid osmotic pressure,...
Forkhead box protein M1 (FOXM1) is an oncogene regulating tumor growth and metastasis. Exosome was suggested to mediate cell communication by delivering active molecules in cancers. However, the existence of FOXM1 circulating exosomes role exosome gastric cancer (GC) were not clear. This study aims investigate potential related long noncoding RNA (FRLnc1) GC.The prepared CD63 immunomagnetic beads (CD63-IMB) had characteristics good dispersity high magnetic response. The isolated presented...
Myocardial fibrosis is the predominant pathological characteristic of diabetic myocardial damage. Previous studies have indicated that hydrogen sulfide (H2S) has beneficial effects in treatment various cardiovascular diseases. However, there little research investigating effect H2S on diabetes. The present study aimed to investigate progression induced by Diabetes was rats intraperitoneal injection streptozotocin. Sodium hydrosulfide (NaHS) used as an exogenous donor H2S. After 8 weeks,...
Pentaerythritol tetranitrate is devoid of nitrate tolerance and shows no reproductive or developmental toxicity in animal studies. Recently, pentaerythritol has been demonstrated to reduce the risk intrauterine growth restriction preterm birth women with abnormal placental perfusion. This study was conducted test perinatal programming effect spontaneously hypertensive rats, a rat model genetic hypertension. Parental rats were treated (50 mg/kg per day) during pregnancy lactation periods;...
Following the pandemic in 2020, physical health has generally declined. All of this is brought on by modifications to body's immune system and consequences sequelae. The current research gap caused neglect COVID-19's after effects. In paper, relationship between changes, complications their conditions was studied, preliminary results harm prevention sequelae were obtained. system's alterations during epidemic infection its are main topics article, including cytokine storms, inflammatory...
Optimizing indoor thermal environments is crucial for enhancing human comfort, particularly in the context of global warming. By innovatively integrating metabolomics, physiological monitoring, cognitive performance analysis, and subjective comfort evaluations, this study investigated impacts three air conditioning (AC) on 20 middle-aged women volunteers. The conditions were as follows: (A) refreshing mode, (B) cooling floor heating modes, (C) mode at 24 °C with RH 50%. Evaluations included...
Throughout the dewatering process of construction slurry, geotechnical properties, including permeability and shear strength, vary with moisture content different water components in such as capillary adsorptive water. This study used thermogravimetric analysis (TGA) kinetic to identify quantify slurry following pressurised electro-osmotic (PEOD). To determine parameters accurately slurry’s components, TGA was performed on samples post-PEOD, a heating rate 9°C/min, across various (M c )...
Endoplasmic reticulum (ER) stress is critical in the occurrence and development of diabetic cardiomyopathy (DC). Hydrogen sulfide (H2S) has been found to be third gaseous signaling molecule with anti‑ER effects. Previous studies have shown that H2S acts as a potent inhibitor fibrosis heart rats. This study aimed demonstrate whether exhibits protective effects on myocardium streptozotocin (STZ)‑induced rats by suppressing ER stress. In this study, models were established intraperitoneal...
Novel components in the noncanonical Hippo pathway that mediate growth, metastasis, and drug resistance of breast cancer (BC) cells need to be identified. Here, we showed expression SAM SH3 domain-containing protein 1 (SASH1) is negatively correlated with mitogen-activated kinase 4 (MAP4K4) a subpopulation patients luminal-subtype BC. Downregulated SASH1 upregulated MAP4K4 synergistically regulated proliferation, migration, invasion BC cells. The LATS2, SASH1, YAP1 phosphorylation were by...
Cardiovascular events are important co-morbidities in patients with chronic inflammatory diseases like rheumatoid arthritis. Tristetraprolin (TTP) regulates pro-inflammatory processes through mRNA destabilization and therefore TTP-deficient mice (TTP−/− mice) develop a inflammation resembling human We used this mouse model to evaluate molecular signaling pathways contributing the enhanced atherosclerotic risk diseases. In aorta of TTP−/− we observed elevated expression known TTP targets...
Background Thymosin alpha 1 (Tα1) is widely used to treat patients with COVID-19 in China; however, its efficacy remains unclear. This study aimed explore the of Tα1 as a therapy. Methods We performed multicenter cohort five tertiary hospitals Hubei province China between December 2019 and March 2020. The patient non-recovery rate was primary outcome. Results All crude outcomes, including (65/306 vs. 290/1,976, p = 0.003), in-hospital mortality (62/306 271/1,976, intubation (31/306...