A5013853415- Orthopedic Infections and Treatments
- Infective Endocarditis Diagnosis and Management
- Transplantation: Methods and Outcomes
- Molecular Biology Techniques and Applications
- Cardiovascular Function and Risk Factors
- Antimicrobial Resistance in Staphylococcus
- Hematological disorders and diagnostics
- Cancer-related molecular mechanisms research
- Musculoskeletal Disorders and Rehabilitation
- Cardiac Valve Diseases and Treatments
- Microbial infections and disease research
- Osteomyelitis and Bone Disorders Research
- Mitochondrial Function and Pathology
- Cardiac Imaging and Diagnostics
- COVID-19 diagnosis using AI
University Hospital Regensburg
2021-2024
University Medical Centre Mannheim
2024
Heidelberg University
2024
University Hospital Heidelberg
2024
University of Regensburg
2022-2024
One of the most important complications heart transplantation is organ rejection, which diagnosed on endomyocardial biopsies by pathologists. Computer-based systems could assist in diagnostic process and potentially improve reproducibility. Here, we evaluated feasibility using deep learning predicting degree cellular rejection from pathology slides as defined International Society for Heart Lung Transplantation (ISHLT) grading system.
Osteomyelitis is a difficult-to-treat disease with high chronification rates. First studies suggest increases in mitochondrial fission and dysfunction as possible contributors to the accumulation of intracellular reactive oxygen species thereby cell death infected bone cells. The aim present study analyze ultrastructural impact bacterial infection on osteocytic osteoblastic mitochondria. Human tissue samples were visualized via light microscopy transmission electron microscopy. Osteoblasts,...
The pathophysiological role of intracellular bacteria in osteomyelitis is still a matter debate. Here, we demonstrate for the first time presence Staphylococcus aureus internalized into osteoblasts human tissue samples case with chronic using ultrastructural transmission electron microscope analysis.
Abstract Background and Aims One of the most important complications heart transplantation is organ rejection, which diagnosed on endomyocardial biopsies by pathologists. Computer-based systems could assist in diagnostic process potentially improve reproducibility. Here, we evaluated feasibility using deep learning predicting degree cellular rejection from pathology slides as defined International Society for Heart Lung Transplantation (ISHLT) grading system. Methods We collected 1079...
Background: Mitochondria play a crucial role in adapting to fluctuating energy demands, particularly various heart diseases. This study investigates mitochondrial morphology near intercalated discs left ventricular (LV) tissues, comparing samples from patients with sinus rhythm (SR), atrial fibrillation (AF), dilated cardiomyopathy (DCM), and ischemic (ICM). Methods: Transmission electron microscopy was used analyze mitochondria within 0–3.5 μm 3.5–7 of 9 SR, 10 AF, DCM, 8 ICM patient...
Multidisciplinary team (MDT) meetings have emerged as a promising approach for the treatment of cancer patients. These involve healthcare professionals from different disciplines working together to develop holistic, patient-centered treatment. Although MDT are well established in oncology, they play minor role other diseases. Recent evidence suggests that implementation can improve patient outcomes musculoskeletal infections. The aim this retrospective, observational study was present...