A5048477745- Immune cells in cancer
- Ethics in Clinical Research
- Radiomics and Machine Learning in Medical Imaging
- Cellular Mechanics and Interactions
- Tissue Engineering and Regenerative Medicine
- Musculoskeletal Disorders and Rehabilitation
- Cardiovascular Function and Risk Factors
- Blood properties and coagulation
- Wound Healing and Treatments
- Cancer Immunotherapy and Biomarkers
- Cardiac Valve Diseases and Treatments
- Orthopedic Infections and Treatments
- Cancer-related Molecular Pathways
- Biomedical Ethics and Regulation
- Lymphatic System and Diseases
- Medical Imaging and Pathology Studies
- Metabolism, Diabetes, and Cancer
- Genetic factors in colorectal cancer
- Hematological disorders and diagnostics
- Biosimilars and Bioanalytical Methods
- Knee injuries and reconstruction techniques
- Nerve injury and regeneration
- 3D Shape Modeling and Analysis
- Computer Graphics and Visualization Techniques
- PI3K/AKT/mTOR signaling in cancer
Heidelberg University
2023-2025
University Medical Centre Mannheim
2023-2025
University Hospital Heidelberg
2023-2025
University of Regensburg
2022-2024
University Hospital Regensburg
2022-2023
Background: The intermediate filament nestin was first described in stem and progenitor cells of neural mesenchymal origin. Additionally, it is expressed endothelial during wound healing tumorigenesis. Thus, widely regarded as a marker for proliferative endothelium. However, little known about its role lymphatic Methods: Here, we analyzed the expression endothelium ten human haemangiomas lymphangiomas situ by immunohistochemistry. This study aimed to investigate determine potential vascular...
Biobanking is essential for advancing precision medicine. However, challenges persist in raising public awareness and addressing data protection concerns. This brief report outlines dissemination strategies by the Central Biobank Regensburg (Zentrale Regensburg-ZBR) BRoTHER (Biobank Research on Telemedical Approaches Human Biobanks a European Region) network to engage relevant target groups. In this context, five key recommendations are derived: (1) tailoring communication audience needs,...
Angiogenesis is the process of new blood vessels growing from existing vasculature. Visualizing them as a three-dimensional (3D) model challenging, yet relevant, task it would be great help to researchers, pathologists, and medical doctors. A branching analysis on 3D further facilitate research diagnostic purposes. In this paper, pipeline vision algorithms elaborated visualize analyze in formalin-fixed paraffin-embedded (FFPE) granulation tissue sections with two different staining methods....
Evaluating the tumor microenvironment and its influence on clinical management therapy response is becoming increasingly important. However, only a few studies deal with spatial distribution of immune cells within tumor. This study aimed to describe topology in oral squamous cell carcinoma (OSCC) sectioned by invasion front center test their prognostic relevance regarding patient survival. A total 55 OSCC specimens were collected retrospectively. The cancer tissue was immunohistochemically...
(1) Background Oral squamous cell carcinomas (OSCC) are a common malignancy of the oral cavity and often diagnosed when they have already spread to regional lymph nodes. Advanced stages cancer characterized by development distant metastases. Angiogenesis, hallmark cancer, is known contribute progression metastasis. High microvessel density (MVD) has been linked poor clinical outcomes in various types cancer. (2) Methods: In this study, we aimed investigate spatial heterogeneity blood vessels...
Background: The anti-neoplastic activity of metformin is a subject current debate. Preclinical data have suggested that enhances PD-L1 anti-tumor effects in various cancer entities by decreasing insulin levels and inducing energetic stress. However, its impact on expression remains unclear clinical setting. Therefore, we aim to investigate the treatment type 2 diabetes mellitus (DM) patients with oral squamous cell carcinoma (OSCC). Methods: We performed retrospective analysis DM OSCC...
Background: Mitochondria play a crucial role in adapting to fluctuating energy demands, particularly various heart diseases. This study investigates mitochondrial morphology near intercalated discs left ventricular (LV) tissues, comparing samples from patients with sinus rhythm (SR), atrial fibrillation (AF), dilated cardiomyopathy (DCM), and ischemic (ICM). Methods: Transmission electron microscopy was used analyze mitochondria within 0–3.5 μm 3.5–7 of 9 SR, 10 AF, DCM, 8 ICM patient...
Multidisciplinary team (MDT) meetings have emerged as a promising approach for the treatment of cancer patients. These involve healthcare professionals from different disciplines working together to develop holistic, patient-centered treatment. Although MDT are well established in oncology, they play minor role other diseases. Recent evidence suggests that implementation can improve patient outcomes musculoskeletal infections. The aim this retrospective, observational study was present...
Cell nuclei interpretation is crucial in pathological diagnostics, especially tumor specimens. A critical step computational pathology to detect and analyze individual nuclear properties using segmentation algorithms. Conventionally, a semantic network used, where are derived after post-processing mask. In this study, we focus on showing that an object-detection-based instance network, the Mask R-CNN, integrating it with Feature Pyramidal Network (FPN), gives mature reliable results for...
Synthetic macroporous biomaterials are widely used in the field of skin tissue engineering to mimic membrane functions native dermis. Biomaterial designs can be subclassified with respect their shape fibrous designs, namely fibers, meshes or fleeces, respectively, and porous such as sponges foams. However, synthetic matrices often have limitations regarding unfavorable foreign body responses (FBRs). Severe FBRs result disintegration rejection an implant, whereas mild lead acceptable...
The anterior cruciate ligament (ACL) plays a significant role in knee stability, protects the joint under multiple loading conditions and shows complex biomechanics. Beside mechanical ACL seems to play crucial proprioception, it is well known, that injuries can cause functional deficits due decreased proprioception. However, mechanism of proprioception not completely understood yet. In this context, primary cilia (PC), which signaling between intra- extracellular space, could be interest....