A5071135585- Glioma Diagnosis and Treatment
- Virology and Viral Diseases
- Viral Infections and Vectors
- Radiomics and Machine Learning in Medical Imaging
- Rabies epidemiology and control
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Glycosylation and Glycoproteins Research
- Medical Imaging Techniques and Applications
- Cell Image Analysis Techniques
- Brain Metastases and Treatment
- Multiple Sclerosis Research Studies
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- MRI in cancer diagnosis
- Neurofibromatosis and Schwannoma Cases
- Mosquito-borne diseases and control
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- AI in cancer detection
- Ubiquitin and proteasome pathways
- Brain Tumor Detection and Classification
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
University of Augsburg
2022-2025
Technical University of Munich
2017-2024
University Hospital Augsburg
2024
Klinikum rechts der Isar
2017-2022
München Klinik
2021
Ludwig-Maximilians-Universität München
2012-2016
Klinik für Frauenheilkunde
2013-2015
Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
2015
Changes in gut microbiota composition and a diverse role of B cells have recently been implicated multiple sclerosis (MS), central nervous system (CNS) autoimmune disease. Immunoglobulin A (IgA) is key regulator at the mucosal interface. However, whether shape IgA responses what IgA+ neuroinflammation are unknown. Here, we identify IgA-bound taxa MS show that IgA-producing specific for MS-associated traffic to inflamed CNS, resulting strong, compartmentalized enrichment active other...
Objective The number of diagnosed fatal encephalitis cases in humans caused by the classical Borna disease virus (BoDV‐1) has been increasing, ever since it was proved that BoDV‐1 can cause human infections. However, awareness this entity is low, and a specific imaging pattern not yet identified. We therefore provide first comprehensive description morphology encephalitis, with histopathological verification abnormalities. Methods In an institutional review board‐approved multicenter study,...
Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor in adults. Despite extensive therapy prognosis for GBM patients remains poor extraordinary resistance has been attributed to intertumoral heterogeneity of glioblastoma. Different prognostic relevant subtypes have identified based on their molecular profile. This approach, however, neglects within individual tumors, that is, intratumoral heterogeneity. Here, we detected regional immunoreactivity by...
The aim of the current study was to enlighten evolution prostate-specific membrane antigen (PSMA) expression in glioblastoma between initial diagnosis and recurrence order provide preliminary insight for further clinical investigations into innovative PSMA-directed treatment concepts neuro-oncology.Patients who underwent resection de-novo (GBM) had a re-resection case recurrent tumor following radiochemotherapy subsequent chemotherapy were included (n = 16). Histological immunohistochemical...
Abstract Background The aim of this clinical trial was to compare Fluorescein-stained intraoperative confocal laser endomicroscopy (CLE) intracranial lesions and evaluation by a neuropathologist with routine frozen section (FS) assessment neuropathology. Methods In phase II noninferiority, prospective, multicenter, nonrandomized, off-label (EudraCT: 2019-004512-58), patients above the age 18 years any lesion scheduled for elective resection were included. diagnostic accuracies both CLE FS...
After many years of controversy, there is now recent and solid evidence that classical Borna disease virus 1 (BoDV-1) can infect humans. On the basis six brain autopsies, we provide first systematic overview on BoDV-1 tissue distribution lesion pattern in fatal BoDV-1-induced encephalitis. All brains revealed a non-purulent, lymphocytic sclerosing panencephalomyelitis with detection BoDV-1-typical eosinophilic, spherical intranuclear Joest–Degen inclusion bodies. While composition...
Abstract Purpose Imaging glioma biology holds great promise to unravel the complex nature of these tumors. Besides well-established imaging techniques such O-(2-[18F]fluoroethyl)- l -tyrosine (FET)-PET and dynamic susceptibility contrast (DSC) perfusion imaging, amide proton transfer–weighted (APTw) has emerged as a promising novel MR technique. In this study, we aimed better understand relation between biomarkers how well they capture cellularity vascularity in newly diagnosed gliomas....
BACKGROUND: Glioblastoma (GBM) is the most malignant primary brain tumor. Relapse occurs regularly, and clinical behavior seems to be due a therapy-resistant subpopulation of glioma-initiating cells that belong group cancer stem cells. Aldehyde dehydrogenase (ALDH) has been identified as marker for this cell population, we have shown previously ALDH1A3-positive GBM are more resistant against temozolomide (TMZ) treatment. However, it still unclear how ALDH expression mediates chemoresistance....
We present three cases fulfilling diagnostic criteria of hemorrhagic variants acute disseminated encephalomyelitis (acute encephalomyelitis, AHEM) occurring within 9 days after the first shot ChAdOx1 nCoV-19. AHEM was diagnosed using magnetic resonance imaging, cerebrospinal fluid analysis and brain biopsy in one case. The close temporal association with vaccination, immune-related nature disease as well lack other canonical precipitating factors suggested that a vaccine-related adverse...
Diffusion tensor imaging (DTI), and fractional-anisotropy (FA) maps in particular, have shown promise predicting areas of tumor recurrence glioblastoma. However, analysis peritumoral edema, where most recurrences occur, is impeded by free-water contamination. In this study, we evaluated the benefits a novel, deep-learning-based approach for correction (FWC) DTI data prediction later recurrence. We investigated 35 glioblastoma cases from our prospective glioma cohort. A preoperative MR image...
Abstract Medulloblastomas (MBs) are malignant pediatric brain tumors that molecularly and clinically heterogenous. The application of omics technologies—mainly studying nucleic acids—has significantly improved MB classification stratification, but treatment options still unsatisfactory. proteome their N-glycans hold the potential to discover relevant phenotypes targetable pathways. We compile a harmonized dataset 167 MBs integrate findings with DNA methylome, transcriptome N-glycome data....
Despite the availability of various therapy options and being a widely focused research area, prognosis glioblastoma (GBM) still remains very poor due to resistance, genetic heterogeneity diffuse infiltration pattern. The recently described non-apoptotic form cell death ferroptosis may, however, offer novel opportunities for targeted therapies. Hence, aim this study was investigate potential role in GBM, including impact treatment on expression two ferroptosis-associated players...
Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB) are neurodegenerative disorders alpha-synuclein (α-syn) aggregation pathology. Different strains of α-syn unique properties suggested to cause distinct clinical pathological manifestations resulting in PD, MSA, or DLB. To study individual spreading patterns, we injected fibrils amplified from brain homogenates two MSA patients PD into the brains C57BI6/J mice. Antibody staining against pS129-α-syn...
Temozolomide (TMZ) is standard treatment for glioblastoma (GBM); nonetheless, resistance and tumor recurrence are still major problems. In addition to its association with recurrent GBM TMZ resistance, ALDH1A3 has a role in autophagy-dependent ferroptosis activation. this study, we treated TMZ-resistant LN229 human cells the inducer RSL3. Remarkably, clones were also resistant induction, although lipid peroxidation was induced by By using Western blotting, able determine that down-regulated...
Abstract Background For recurrent glioblastoma (GB) patients, several therapy options have been established over the last years such as more aggressive surgery, re-irradiation or chemotherapy. Age and Karnofsky Performance Status Scale (KPSS) are used to make decisions for these patients prognostic factors in initial diagnosis of GB. This study’s aim was evaluate preoperative patient comorbidities by using age-adjusted Charlson Comorbidity Index (ACCI) a factor GB patients. Methods In this...
Despite the addition of immune checkpoint blockade to first-line chemotherapy, prognosis for patients with small cell lung cancer (SCLC) is still devastating. For subset SCLC somatostatin receptor (SSTR) overexpression, radiopharmaceutical therapy (RPT) might be an effective future treatment option. <b>Methods:</b> Here, we present case a heavily pretreated stage IV patient showing exceptional response SSTR-directed RPT. A comprehensive translational work-up consisting histopathologic,...
Abstract Infectious encephalitis in children can be caused by several pathogens, very rarely this bornaviruses (BoDV-1). Due to the recent discovery of disease humans and small number cases, especially pediatric infections, knowledge about pathology as well therapeutic options is limited. Therefore, review shall help raise awareness rare mostly fatal disease, promote an early diagnosis, present current possible treatment options.
Manual segmentation of histopathological images is both resource-intensive and prone to human error, particularly when dealing with challenging tumor types like Glioblastoma (GBM), an aggressive highly heterogeneous brain tumor. The fuzzy borders GBM make it especially difficult segment, requiring models strong generalization capabilities achieve reliable results. In this study, we leverage the Medical Open Network for Artificial Intelligence (MONAI) framework segment tissue from hematoxylin...