A5037438061- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic function and diabetes
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Metabolism, Diabetes, and Cancer
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Adrenal and Paraganglionic Tumors
- Advanced Proteomics Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Hormonal Regulation and Hypertension
- Metastasis and carcinoma case studies
- Diabetes Treatment and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
Helmholtz Zentrum München
2016-2025
Center for Environmental Health
2020-2025
Helmholtz Association of German Research Centres
2020-2022
Technical University of Munich
2003-2016
Klinikum rechts der Isar
2013
Lantheus Medical Imaging (United States)
2013
Taipei Institute of Pathology
2012
Ludwig-Maximilians-Universität München
2006
Institute of Groundwater Ecology
2001
Kinase inhibitors are important cancer therapeutics. Polypharmacology is commonly observed, requiring thorough target deconvolution to understand drug mechanism of action. Using chemical proteomics, we analyzed the spectrum 243 clinically evaluated kinase drugs. The data revealed previously unknown targets for established drugs, offered a perspective on "druggable" kinome, highlighted (non)kinase off-targets, and suggested potential therapeutic applications. Integration phosphoproteomic...
Adrenal aldosterone excess is the most common cause of secondary hypertension and associated with increased cardiovascular morbidity. However, adverse metabolic risk in primary aldosteronism extends beyond hypertension, rates insulin resistance, type 2 diabetes, osteoporosis, which cannot be easily explained by excess.We performed mass spectrometry-based analysis a 24-hour urine steroid metabolome 174 newly diagnosed patients (103 unilateral adenomas, 71 bilateral adrenal hyperplasias)...
Uncertainty exists as to whether the glucose-dependent insulinotropic polypeptide receptor (GIPR) should be activated or inhibited for treatment of obesity. Gipr was recently demonstrated in hypothalamic feeding centers, but physiological relevance CNS remains unknown. Here we show that HFD-fed CNS-Gipr KO mice and humanized (h)GIPR knockin with CNS-hGIPR deletion decreased body weight improved glucose metabolism. In DIO mice, acute central peripheral administration acyl-GIP increases cFos...
The N-methyl-D-aspartate (NMDA) receptor is a glutamate-activated cation channel that critical to many processes in the brain. Genome-wide association studies suggest glutamatergic neurotransmission and NMDA receptor-mediated synaptic plasticity are important for body weight homeostasis
Autoimmune uveitis is a blinding disease presenting with autoantibodies against eye-specific proteins as well autoagressive T cells invading and attacking the immune-privileged target tissue retina. The molecular events enabling to invade attack have remained elusive. Changes in membrane protein expression patterns between diseased healthy stages are especially interesting because initiating of will most likely occur at membranes. Since progression accompanied break-down blood-retinal...
Abstract We present the first analytical approach to demonstrate in situ imaging of metabolites from formalin‐fixed, paraffin‐embedded ( FFPE ) human tissue samples. Using high‐resolution matrix‐assisted laser desorption/ionization Fourier‐transform ion cyclotron resonance mass spectrometry MALDI‐FT‐ICR MSI ), we conducted a proof‐of‐principle experiment comparing metabolite measurements and fresh frozen sections, found an overlap 72% amongst 1700 m/z species. In particular, observed...
Glioblastoma multiforme (GBM) is the most frequent and aggressive primary brain tumor in adults. Despite extensive therapy prognosis for GBM patients remains poor extraordinary resistance has been attributed to intertumoral heterogeneity of glioblastoma. Different prognostic relevant subtypes have identified based on their molecular profile. This approach, however, neglects within individual tumors, that is, intratumoral heterogeneity. Here, we detected regional immunoreactivity by...
Abstract Purpose: Current systems of gastric cancer molecular classification include genomic, molecular, and morphological features. Gastric based on tissue metabolomics remains lacking. This study aimed to define metabolically distinct subtypes identify their clinicopathological characteristics. Experimental Design: Spatial by high mass resolution imaging spectrometry was performed in 362 patients with cancer. K−means clustering used tumor stroma-related metabolites. The identified were...
Abstract The development of single-molecule co-agonists for the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIP) (GIPR) is considered a breakthrough in treatment obesity type 2 diabetes. But although GIPR–GLP-1R co-agonism decreases body weight with superior efficacy relative to GLP-1R agonism alone preclinical 1–3 clinical studies 4,5 , role GIP regulating energy metabolism remains enigmatic. Increasing evidence suggests that...
Excess copper causes hepatocyte death in hereditary Wilson's disease (WD). Current WD treatments by copper-binding chelators may gradually reduce overload; they fail, however, to bring hepatic close normal physiological levels. Consequently, lifelong daily dose regimens are required hinder progression. This result severe issues due nonadherence or unwanted adverse drug reactions and also switching ultimate treatment failures. study comparatively tested bacteria-derived binding...
Cancer cells convert glucose preferentially to lactate even in the presence of oxygen (aerobic glycolysis–Warburg effect). New concepts cancer treatment aim at inhibition aerobic glycolysis. Pyruvate dehydrogenase converts pyruvate acetylCoA thus preventing formation. Therefore, this study was evaluate compounds that could activate cells. We investigated effects (R)-(+)-α-lipoic acid (LPA) and dichloroacetate (DCA), possible activators dehydrogenase, on suppression glycolysis induction cell...
Individuals carrying loss-of-function gene mutations for the adipocyte hormone leptin are morbidly obese, but respond favorably to replacement therapy. Recombinant is however largely ineffective vast majority of obese individuals due resistance. One theory underlying resistance impaired transport across blood–brain-barrier (BBB). Here, we aim gain new insights into mechanisms BBB transport, and its role in We developed a novel tool visualizing using infrared fluorescently labeled leptin,...