A5072286749- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
German Centre for Cardiovascular Research
2022
Universitätsmedizin Göttingen
2021
Atrial fibrillation (AF) and heart failure often coexist, but their interaction is poorly understood. Clinical data indicate that the arrhythmic component of AF may contribute to left ventricular (LV) dysfunction. This study investigates effects molecular mechanisms on human LV. Ventricular myocardium from patients with aortic stenosis preserved LV function sinus rhythm or rate-controlled was studied. showed no differences in fibrosis. In functional studies, systolic Ca2+ transient amplitude...
Introduction: The effects of atrial fibrillation (AF) on left ventricular (LV) function are poorly understood. Clinical data indicate that the arrhythmic component AF may contribute to LV dysfunction. This study investigated human LV. Methods and Results: myocardium from patients with preserved (EF>50%) sinus rhythm (SR, n=31) or rate-controlled (n=24) obtained during surgery for aortic stenosis was studied. were mostly balanced without changes in remodeling. SR showed no fibrosis. In...