A5038934355- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Polish Legal and Social Issues
- Local Governance and Planning
- Polish Law and Legal System
- Nonmelanoma Skin Cancer Studies
- Mast cells and histamine
- Urticaria and Related Conditions
- Food Allergy and Anaphylaxis Research
- Spondyloarthritis Studies and Treatments
- Systemic Sclerosis and Related Diseases
- Nail Diseases and Treatments
- Genetic and rare skin diseases.
- Retinoids in leukemia and cellular processes
- Autoimmune Bullous Skin Diseases
- Leadership, Behavior, and Decision-Making Studies
- Heme Oxygenase-1 and Carbon Monoxide
- Immune responses and vaccinations
- Porphyrin Metabolism and Disorders
- Dermatologic Treatments and Research
- Psychological Well-being and Life Satisfaction
- Systemic Lupus Erythematosus Research
- Hidradenitis Suppurativa and Treatments
University Medical Center of the Johannes Gutenberg University Mainz
2014-2025
Johannes Gutenberg University Mainz
2014-2025
University Hospital and Clinics
2025
University Medical Center
2025
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2020-2022
Hautklinik Heidelberg
2022
University of Łódź
2020
Nicolaus Copernicus University
2017
Institute for Molecular Medicine
2014
Universitätsklinikum Erlangen
2014
Interleukin (IL)-17A is regarded as an important cytokine to drive psoriasis, inflammatory skin disease marked by increased cardiovascular mortality. We aimed test the hypothesis that overproduction of IL-17A in leading dermal inflammation may systemically cause vascular dysfunction psoriasis-like disease.Conditional overexpression keratinocytes caused severe mice (K14-IL-17A(ind/+) mice), associated with reactive oxygen species formation and circulating CD11b(+) leukocytes blood,...
Abstract Aim Recent evidence suggests that arterial hypertension could be alternatively explained as a physiological adaptation response to water shortage, termed aestivation, which relies on complex multi‐organ metabolic adjustments prevent dehydration. Here, we tested the hypothesis chronic loss across diseased skin leads similar adaptive conservation responses observed in experimental renal failure or high salt diet. Methods We studied mice with keratinocyte‐specific overexpression of...
<title>Abstract</title> Morphea (limited scleroderma) is a chronic, autoimmune disease of connective tissue that has been known for many years. However, the etiology still not fully understood. The study was conducted on group 88 people, including 59 patients with morphea and 29 people qualified control group. We attempted to assess gene expression plasma concentration IL-1β, IL-18 IL-33. In morphea, lower IL1 beta IL18 genes observed in PBMC compared group, no significant differences...
ABSTRACT Background Afamelanotide 16 mg (SCENESSE) is the first approved treatment for erythropoietic protoporphyria (EPP). EPP a rare autosomal recessive inherited disorder of haem biosynthesis pathway, where patients experience severe and debilitating acute phototoxicity. It affects at least one in 140,000 European population. A postauthorisation safety study (PASS) disease registry were imposed as conditions marketing authorisation. Objectives Evaluate short‐ long‐term clinical...
Psoriasis is a frequent systemic inflammatory autoimmune disease characterized primarily by skin lesions with massive infiltration of leukocytes but frequently also presents cardiovascular comorbidities. Especially polymorphonuclear neutrophils (PMNs) abundantly infiltrate psoriatic the cues that prompt PMNs to home are not well defined. To identify PMN surface receptors may explain homing in psoriasis patients, we screened 332 antigens on primary human blood from healthy donors and...
Hidradenitis suppurativa is a chronic inflammatory disease with high burden. Treatment options are often unsatisfactory. We assessed the effect of combination therapy intense pulsed light (IPL) and radiofrequency (RF).The explorative study included 47 patients was performed as prospective, monocentric, randomized, three-arm parallel-group design trial prior 12 weeks observation period. arms were IPL RF monotherapies or + therapy. After weeks, all received for additional (cross-over). Primary...
Background Psoriasis is a frequent chronic inflammatory cytokine‐mediated skin disease and was identified to be an independent risk factor for the occurrence of myocardial infarction (MI). However, data about impact psoriasis on mortality other in‐hospital adverse events in setting MI are sparse inconsistent. Methods Results The nationwide German inpatient sample years 2005 2016 used statistical analysis. Hospitalized patients with were stratified presence investigated. Overall, 3 307 703...
LL37 alone and in complex with self-DNA triggers inflammatory responses myeloid cells plays a crucial role the development of systemic autoimmune diseases, like psoriasis lupus erythematosus. We demonstrated that LL37/self-DNA complexes induce long-term metabolic epigenetic changes monocytes, enhancing their responsiveness to subsequent stimuli. Monocytes trained those derived from psoriatic patients exhibited heightened glycolytic oxidative phosphorylation rates, elevated release...
Zusammenfassung Hintergrund Chronische Entzündungserkrankungen (engl. „immune-mediated inflammatory diseases“ [IMID]) sind mit einer erheblichen Krankheitslast verbunden. Diese ist umso ausgeprägter, sofern diese gleichzeitig bei Patienten auftreten oder z. B. weitere Komorbiditäten bestehen. Die Versorgung der IMID komplex und involviert diverse medizinische Fachdisziplinen. Ziel Arbeit Beschreibung aktuellen Arzneimittelversorgung IMID. Material Methoden retrospektive Querschnittanalyse...
Psoriasis is one of the most common chronic inflammatory skin diseases and at same time a risk factor for cardiovascular disease. Interleukin-17A (IL-17A)-mediated inflammation in psoriasis may lead to vascular dysfunction. This study aimed investigating whether anti-inflammatory treatment by tumor necrosis (TNF)-α blockade alters function patients. A total 11 patients with who underwent either adalimumab (n = 8) or etanercept 3), 10 healthy control individuals 14 coronary artery disease...
Background: Standard treatment options for urticaria are second-generation antihistamines; however, their effect on sleep is uncertain. This study measures the influence of different antihistamines biologic pattern patients and relevance in patients. Methods: Ten with chronic spontaneous (CSU) uncontrolled symptoms under a single dose were included. Two nights monitored: first night after 5 days dosage second fourfold dosage. Patient-rated questionnaires used was monitored using polygraphy....
The aim of the paper is to identify key functions performed by leaders in organisations, and study how positive affect their teams results achieved subordinates. analyses, through lens leadership, importance motivation, communication between organisational members, as well delegation transfer responsibility manifested classical theories leadership. literature survey main data collection technique applied achieve paper.
Abstract Graft‐versus‐host disease (GvHD) is a major complication following stem‐cell or solid‐organ transplantation. Accurate diagnosis of cutaneous GvHD challenging, given that drug eruptions and viral rashes may present with similar clinical/histological manifestations. Specific markers are not available. We performed the histological examination biopsy samples from acute (aGvHD; n = 54), Stevens‐Johnson syndrome/toxic epidermal necrolysis (SJS/TEN; 27), maculopapular eruption (MDE; 26)...
Zusammenfassung Einleitung Die Prävalenz atopischer Erkrankungen ist weiterhin hoch. Erste Studien deuten darauf hin, dass die Primärprävention mit regelmäßiger Basispflege das Auftreten von Dermatitis bei Säuglingen beeinflussen könnte, allerdings Datenlage nicht ganz eindeutig. Hebammen spielen eine wichtige Rolle der Betreuung Frauen in Peripartalzeit und damit auch Beratung zu Themen wie Hautpflege, Stillen Ernährung des Neugeborenen jungen Säuglings. Ziel dieser Studie war es,...
Background: Disseminated superficial actinic porokeratosis (DSAP) is a rare dermatologic disorder of the epidermis. Often misdiagnosed as chronic UV-damage or keratoses, patients are treated for years with different therapeutic options little success. Current treatment include imiquimod, ingenol mebutate, cryosurgery, photodynamic therapy and topical systemic retinoids. Since those approaches show only success come along major side effects, alternatives strongly requested. Methods: We report...
Abstract Objective Treatment of recalcitrant moderate‐to‐severe psoriasis can be challenging. Combination therapy biologics and immunosuppressive agents a new strategy for treating therapy‐resistant cases with comorbidities, where many systemic medications are contraindicated. Case presentation We report case 62‐year‐old diabetic man 30‐year history severe plaque psoriatic arthritis cirrhosis nephropathy that was treated successfully in combination apremilast etanercept after multiple...
On 1 June 2017, a major amendment to the Code of Administrative Procedure came into force. The article deals with mediation incorporated as new institution administrative proceedings. authors presented advantages and disadvantages in public matters discussed theoretical foundations this construction. They analysed effectiveness conducted proceedings before courts, pointing that entrusting professional mediators (by amending Act 7 April 2017) was justified. regulation provides for is...