A5060484072- Psoriasis: Treatment and Pathogenesis
- Asthma and respiratory diseases
- Venous Thromboembolism Diagnosis and Management
- Dermatology and Skin Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Inflammation biomarkers and pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Religion, Theology, History, Judaism, Christianity
- Atherosclerosis and Cardiovascular Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Biomarkers in Disease Mechanisms
- Cardiovascular Disease and Adiposity
- Renin-Angiotensin System Studies
- Chemokine receptors and signaling
- S100 Proteins and Annexins
- Thermoregulation and physiological responses
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune cells in cancer
- Antiplatelet Therapy and Cardiovascular Diseases
- Mast cells and histamine
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Climate Change and Health Impacts
- Muscle Physiology and Disorders
- Sodium Intake and Health
- Telomeres, Telomerase, and Senescence
University Medical Center of the Johannes Gutenberg University Mainz
2018-2024
Johannes Gutenberg University Mainz
2018-2024
University Hospital of Bern
2023
University of Bern
2023
German Centre for Cardiovascular Research
2022
University of Cologne
2020
Abstract Aim Recent evidence suggests that arterial hypertension could be alternatively explained as a physiological adaptation response to water shortage, termed aestivation, which relies on complex multi‐organ metabolic adjustments prevent dehydration. Here, we tested the hypothesis chronic loss across diseased skin leads similar adaptive conservation responses observed in experimental renal failure or high salt diet. Methods We studied mice with keratinocyte‐specific overexpression of...
Traffic noise may play an important role in the development and deterioration of ischaemic heart disease. Thus, we sought to determine mechanisms cardiovascular dysfunction inflammation induced by aircraft a mouse model myocardial infarction (MI) humans with incident MI.C57BL/6J mice were exposed alone (average sound pressure level 72 dB; peak 85 dB) for up 4 days, resulting pro-inflammatory aortic gene expression myeloid cell adhesion/diapedesis pathways. The promoted adhesion infiltration...
Abstract Aims Heart failure (HF) ensuing myocardial infarction (MI) is characterized by the initiation of a systemic inflammatory response. We aimed to elucidate impact myelomonocytic cells and their activation angiotensin II on vascular endothelial function in mouse model HF after MI. Methods results was induced male C57BL/6J mice permanent ligation left anterior descending coronary artery. Compared sham, had significantly impaired accompanied enhanced mobilization Sca-1+c-Kit+...
Heart failure (HF) coincides with cardiomyocyte telomere shortening. Arterial hypertension is the most prominent risk factor for HF. Both HF and arterial are associated dysregulation of neurohormonal axis. How activation linked to shortening in pathogenesis incompletely understood. Cardiomyocyte length was assessed a mouse model hypertensive induced by excess (AngII [angiotensin II] infusion, high salt diet, uninephrectomy), AngII-stimulated cardiomyocytes endomyocardial biopsies from...
The cytokine interleukin-6 (IL-6) plays a central role in the inflammation cascade as well cardiovascular disease progression. Since myeloid cells are primary source of IL-6 formation, we aimed to generate mouse model study cell-derived vascular disease.
Abstract The role of leukocytes in deep vein thrombosis (DVT) resolution is incompletely understood. We determined how depletion lysozyme positive (LysM + ) cells and a switched-off type 1 immune response influences thrombus resolution. DVT was induced 12-week-old male mice by inferior vena cava (IVC) stenosis. Toxin mediated myeloid improved with Cre-inducible expression the diphtheria toxin receptor LysM cells. This correlated decreased CD45 cells, population shift Gr-1 to − CD11b...
Activated perivascular mast cells (MCs) participate in different cardiovascular diseases. Many factors provoking MC degranulation have been described, while physiological counterregulators are barely known. Endothelial CNP (C-type natriuretic peptide) participates the maintenance of vascular barrier integrity, but target and mechanisms unclear. Here, we studied whether MCs regulated by CNP. Approach Results: In cultured human murine MCs, activated its specific GC (guanylyl cyclase)-B...
Psoriasis is an immune-mediated inflammatory skin disease driven by interleukin-17A (IL-17A) and associated with cardiovascular dysfunction. We used a severe psoriasis mouse model of keratinocyte IL-17A overexpression (K14-IL-17Aind/+ , IL-17Aind/+ control mice) to investigate the activity neutrophils potential cellular interconnection between vasculature. Levels dermal reactive oxygen species (ROS) their release were measured lucigenin-/luminol-based assays, respectively. Quantitative...
Background: Psoriasis is hallmarked by vascular dysfunction, arterial hypertension, and an increased risk for cardiovascular diseases. We have shown recently that skin-driven interleukin (IL)-17A expression promotes psoriasis-like disease in mice, this associated with inflammation, hypertension. As intensive risk-factor reduction recommended psoriasis patients, we aimed to elucidate the impact of angiotensin II receptor type 1 (AT1) antagonist telmisartan a mouse model severe skin disease....
Cells of the innate immune system, including monocytes and neutrophils, are key players in process venous thrombosis. T lymphocytes have recently been implicated thrombus resolution but role B thrombosis is unknown. The present study was conducted to address this question using a mouse model partial ligation inferior vena cava. Although only very low number cells found thrombi wild-type mice, cell-deficient JHT mutant mice developed larger than controls. Consistent with enhanced...
Background: Psoriasis is a systemic inflammatory disorder, primarily characterized by skin plaques. It linked to co-morbidities including cardiovascular disease and metabolic syndrome. Several studies demonstrate that dietary habits can influence psoriasis development severity. However, the effect of different protein levels on severity poorly understood. In this study, we examine psoriasis-like in mice. Methods: We fed male C57BL/6J mice with regular, low high chow for 4 weeks. Afterwards,...
Abstract Background Ischemic heart failure (HF) ensuing myocardial infarction (MI) leads to impaired left ventricular function, reduced cardiac output and counterregulatory activation of angiotensin II (AngII) levels. Furthermore, it is characterized by the initiation a systemic inflammatory response. Objective We aimed elucidate impact myelomonocytic cells their on vascular endothelial function in mouse model HF after MI. Results was induced male C57BL/6J mice permanent ligation anterior...
Abstract Background Psoriasis is the most common chronic skin disease worldwide. Furthermore, it an independent cardiovascular risk factor. Several genetic and inducible murine models reproduce specific aspects of human disease. In mice genetically overexpressing IL-17A in keratinocytes or dendritic cells, we coulod show both disease: cutaneous hallmarks vascular phenotype. The popular model consists topical application Imiquimod (IMQ), a Toll-like receptor 7/8 agonist. this model, have not...