A5039361810- Nitric Oxide and Endothelin Effects
- Noise Effects and Management
- Air Quality and Health Impacts
- Eicosanoids and Hypertension Pharmacology
- Climate Change and Health Impacts
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adipose Tissue and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Ischemia and Reperfusion
- Redox biology and oxidative stress
- Renin-Angiotensin System Studies
- Cardiovascular Disease and Adiposity
- Heme Oxygenase-1 and Carbon Monoxide
- Diabetes Treatment and Management
- Electron Spin Resonance Studies
- Advanced Glycation End Products research
- Mitochondrial Function and Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- Antioxidant Activity and Oxidative Stress
- Health, Environment, Cognitive Aging
- Vitamin C and Antioxidants Research
- Nutritional Studies and Diet
- Cardiovascular Function and Risk Factors
- Peroxisome Proliferator-Activated Receptors
- Sulfur Compounds in Biology
German Centre for Cardiovascular Research
2016-2025
University Medical Center of the Johannes Gutenberg University Mainz
2016-2025
Johannes Gutenberg University Mainz
2016-2025
Inserm
2011-2024
Centre National de la Recherche Scientifique
2012-2024
University Medical Center
2013-2024
Institut Cochin
2011-2024
Université Paris Cité
2011-2024
University Hospital and Clinics
2024
Danish Cancer Society
2023
Ambient air pollution is a major health risk, leading to respiratory and cardiovascular mortality. A recent Global Exposure Mortality Model, based on an unmatched number of cohort studies in many countries, provides new hazard ratio functions, calling for re-evaluation the disease burden. Accordingly, we estimated excess mortality attributed Europe.The functions have been combined with ambient exposure data estimate impacts Europe 28 countries European Union (EU-28). The annual rate from 790...
Angiotensin II (ATII), a potent vasoconstrictor, causes hypertension, promotes infiltration of myelomonocytic cells into the vessel wall, and stimulates both vascular inflammatory cell NADPH oxidases. The predominant source reactive oxygen species, eg, (endothelial, smooth muscle, adventitial) versus phagocytic oxidase, role in mediating arterial hypertension have not been defined yet. (1 mg · kg(-1) d(-1) for 7 days) increased number CD11b(+)Gr-1(low)F4/80(+) macrophages...
Recruitment and activation of polymorphonuclear neutrophils (PMNs) reflects a primary immunological response to invading pathogens has also emerged as hallmark vascular inflammation. One the principal enzymes released upon PMN is myeloperoxidase (MPO), heme protein that not only generates cytotoxic oxidants but impacts deleteriously on nitric oxide-dependent signaling cascades within vasculature. Because MPO associates with membrane PMN, we evaluated whether could function an autocrine...
In diabetes, vascular dysfunction is characterized by impaired endothelial function due to increased oxidative stress. Empagliflozin, as a selective sodium-glucose co-transporter 2 inhibitor (SGLT2i), offers novel approach for the treatment of type diabetes enhancing urinary glucose excretion. The aim present study was test whether with empagliflozin improves in I diabetic rats via reduction glucotoxicity and associated stress.Type Wistar induced an intravenous injection streptozotocin (60...
Hyperglycemia associated with inflammation and oxidative stress is a major cause of vascular dysfunction cardiovascular disease in diabetes. Recent data reports that selective sodium-glucose co-transporter 2 inhibitor (SGLT2i), empagliflozin (Jardiance®), ameliorates glucotoxicity via excretion excess glucose urine (glucosuria) significantly improves mortality type diabetes mellitus (T2DM). The overarching hypothesis hyperglycemia are upstream all other complications seen aim this study was...
Aims: Oxidative stress is involved in the development of cardiovascular disease. There a growing body evidence for crosstalk between different enzymatic sources oxidative stress. With present study, we sought to determine underlying mechanisms, role mitochondrial permeability transition pore (mPTP), and its link endothelial dysfunction. Results: NADPH oxidase (Nox) activation (oxidative burst translocation cytosolic Nox subunits) was observed response reactive oxygen species (mtROS)...