A5028012680- Noise Effects and Management
- Nitric Oxide and Endothelin Effects
- Air Quality and Health Impacts
- Eicosanoids and Hypertension Pharmacology
- Climate Change and Health Impacts
- Diabetes Treatment and Management
- Advanced Glycation End Products research
- Diet, Metabolism, and Disease
- Renin-Angiotensin System Studies
- Receptor Mechanisms and Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Electron Spin Resonance Studies
- Sulfur Compounds in Biology
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Imaging and Diagnostics
- Neuropeptides and Animal Physiology
- Atherosclerosis and Cardiovascular Diseases
- Pancreatic function and diabetes
- Neuroscience and Neuropharmacology Research
- Metabolism and Genetic Disorders
- Antioxidant Activity and Oxidative Stress
- Smoking Behavior and Cessation
- Air Quality Monitoring and Forecasting
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
Johannes Gutenberg University Mainz
2015-2025
University Medical Center of the Johannes Gutenberg University Mainz
2015-2025
German Centre for Cardiovascular Research
2021-2023
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2023
University Medical Center
2020
In diabetes, vascular dysfunction is characterized by impaired endothelial function due to increased oxidative stress. Empagliflozin, as a selective sodium-glucose co-transporter 2 inhibitor (SGLT2i), offers novel approach for the treatment of type diabetes enhancing urinary glucose excretion. The aim present study was test whether with empagliflozin improves in I diabetic rats via reduction glucotoxicity and associated stress.Type Wistar induced an intravenous injection streptozotocin (60...
Aims: Oxidative stress is involved in the development of cardiovascular disease. There a growing body evidence for crosstalk between different enzymatic sources oxidative stress. With present study, we sought to determine underlying mechanisms, role mitochondrial permeability transition pore (mPTP), and its link endothelial dysfunction. Results: NADPH oxidase (Nox) activation (oxidative burst translocation cytosolic Nox subunits) was observed response reactive oxygen species (mtROS)...
Abstract Aims Electronic (e)-cigarettes have been marketed as a ‘healthy’ alternative to traditional combustible cigarettes and an effective method of smoking cessation. There are, however, paucity data support these claims. In fact, e-cigarettes are implicated in endothelial dysfunction oxidative stress the vasculature lungs. The mechanisms underlying side effects remain unclear. Here, we investigated e-cigarette vapour on vascular function smokers experimental animals determine mechanisms....
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has forced the implementation of unprecedented public health measures strategies which might also have a significant impact on spreading other viral pathogens such as influenza and Respiratory Syncytial Virus (RSV) . present study compares incidences most relevant viruses before during SARS-CoV-2 in emergency room patients. We analyzed results total 14,946 polymerase chain reaction point-of-care tests...
Worldwide, up to 8.8 million excess deaths/year have been attributed air pollution, mainly due the exposure fine particulate matter (PM). Traffic-related noise is an additional contributor global mortality and morbidity. Both health risk factors substantially contribute cardiovascular, metabolic neuropsychiatric sequelae. Studies on combined are rare urgently needed because of frequent co-occurrence both in urban industrial settings. To study synergistic effects PM noise, we used system...
Environmental stressors such as traffic noise represent a global threat, accounting for 1.6 million healthy life years lost annually in Western Europe. Therefore, the noise-associated health side effects must be effectively prevented or mitigated. Non-pharmacological interventions physical activity balanced diet are effective due to activation of adenosine monophosphate-activated protein kinase (α1AMPK). Here, we investigated first time murine model aircraft noise-induced vascular...
Abstract Aims Epidemiology links noise to increased risk of metabolic diseases like diabetes and obesity. Translational studies in humans experimental animals showed that causes reactive oxygen species (ROS)–mediated cardiovascular damage. The interaction between diabetes, specifically potential additive adverse effects, remains be determined. Methods results C57BL/6 mice were treated with streptozotocin (i.p. injections, 50 mg/kg/day for 5 days) induce type 1 mellitus, S961 (subcutaneous...
Noise pollution is a known health risk factor and evidence for cardiovascular diseases associated with traffic noise growing. At least 20% of the European Union’s population lives in noise-polluted areas exposure levels exceeding recommended limits World Health Organization, which considered unhealthy by Environment Agency. This results annual loss 1.6 million healthy life years. Here, we investigated protective effects drug interventions against aircraft noise-mediated complications such as...
Cardiovascular disease is the leading cause of burden and death worldwide fueled by vascular inflammation. CD40L-CD40-TRAF signaling involved in progression atherosclerosis drives development coronary heart (CHD). The present study investigates whether CD40L-CD40-TRAF6 pathway with focus on immune cells adipocytes could be a therapeutic target arterial hypertension. Arterial hypertension was induced WT (C57BL6/J) cell-specific CD40(L) knockout mice (AdipoqCre x CD40 fl/fl, CD4Cre CD19Cre...
We hypothesized that TSH-receptor (TSHR) stimulating antibodies (TSAbs) are involved in oxidative stress mechanisms patients with Graves disease (GD). Nicotinamide adenine dinucleotide phosphate oxidase, isoform 2 (NOX2); parameters; and burst were measured serum, urine, whole blood from GD control subjects. Superoxide production was investigated human embryonic kidney (HEK)-293 cells stably overexpressing the TSHR. Lipid peroxidation determined by immunodot-blot analysis for protein-bound...
The neutrophil recruiting cytokine Interleukin-17A (IL-17A) is a key component in vascular dysfunction and arterial hypertension. Moreover, IL-17A has central role for the infiltration of myeloid cells into wall Angiotensin II-induced inflammation. intention our study was to analyze impact T cell-derived on hypertension, function, Chronic overexpression (CD4-IL-17Aind/+ mice) resulted elevated reactive oxygen species peripheral blood significant compared control mice. seen CD4-IL-17Aind/+...
Transportation noise is recognized as an important cardiovascular risk factor. Key mechanisms are noise-triggered vascular inflammation and oxidative stress with subsequent endothelial dysfunction. Here, we test for adaptation or tolerance in mice response to chronic exposure. C57BL/6J were exposed aircraft 0, 4, 7, 14 28d at a mean sound pressure level of 72 dB(A) peak levels 85 dB(A). Chronic exposure up caused persistent dysfunction elevation blood pressure. Likewise, reactive oxygen...
Vascular oxidative stress, inflammation, and subsequent endothelial dysfunction are consequences of traditional cardiovascular risk factors, all which contribute to disease. Environmental stressors, such as traffic noise air pollution, may also facilitate the development progression metabolic diseases. In our previous studies, we investigated influence aircraft exposure on molecular mechanisms, identifying stress inflammation central players in mediating vascular function. The present study...
Arterial hypertension is one of the major health risk factors leading to coronary artery disease, stroke or peripheral disease.Dietary uptake inorganic nitrite (NO 2 -) and nitrate 3 via vegetables leads enhanced vascular NO bioavailability provides antihypertensive effects.The present study aims understand underlying vasoprotective effects nutritional -and -co-therapy in mice with angiotensin-II (AT-II)-induced arterial hypertension.High-dose AT-II (1 mg/kg/d, 1w, s. c.) was used induce...
Abstract Electronic cigarettes (E-cigarettes) have recently become a popular alternative to traditional tobacco cigarettes. Despite being marketed as healthier alternative, increasing evidence shows that E-cigarette vapour could cause adverse health effects. It has been postulated degradation products of liquid, mainly reactive aldehydes, are responsible for those Previously, we demonstrated exposure causes oxidative stress, inflammation, apoptosis, endothelial dysfunction and hypertension...
Background: Large epidemiological studies point towards a link between the incidence of arterial hypertension, ischaemic heart disease, metabolic disease and exposure to traffic noise, supporting role noise as an independent cardiovascular risk factor. We characterised underlying molecular mechanisms leading noise-dependent adverse effects on vasculature myocardium in animal model aircraft identified oxidative stress inflammation central players mediating vascular cardiac dysfunction. Here,...
Glutathione (γ-L-glutamyl-L-cysteinyl-glycine, GSH) is a tripeptide that part of the antioxidant defense system and contributes to numerous redox-regulatory processes. In vivo, reduced GSH oxidized glutathione disulfide (GSSG) are present in redox equilibrium their ratio provides important information on cellular state. Here, we compared three different methods for vivo quantification tissues hypertensive rats, an accepted animal model oxidative stress. study, used rats (infusion 1 mg/kg/d...
Doxorubicin (DOX) is an important drug for the treatment of various tumor entities. However, occurrence heart failure limits its application. This study investigated differential gene expression profiles in left and right ventricles DOX treated mice with either preserved or impaired myocardial function. We provide new mechanistic insights into pathophysiology DOX-induced have discovered pathways that counteract cardiotoxicity. used total 48 male applied a chronic low dose administration (5...