A5021753154- Psoriasis: Treatment and Pathogenesis
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Sodium Intake and Health
- Infective Endocarditis Diagnosis and Management
- Transplantation: Methods and Outcomes
- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
- Actinomycetales infections and treatment
- Venous Thromboembolism Diagnosis and Management
- Mechanical Circulatory Support Devices
- Sepsis Diagnosis and Treatment
- Inflammation biomarkers and pathways
- Cardiac Imaging and Diagnostics
- Thermoregulation and physiological responses
- Signaling Pathways in Disease
- Respiratory Support and Mechanisms
- Acute Ischemic Stroke Management
- Hormonal Regulation and Hypertension
- Cardiac Fibrosis and Remodeling
- Neuroinflammation and Neurodegeneration Mechanisms
- Therapeutic Uses of Natural Elements
- S100 Proteins and Annexins
- Coronary Interventions and Diagnostics
- Dietary Effects on Health
University Medical Center of the Johannes Gutenberg University Mainz
2018-2024
Johannes Gutenberg University Mainz
2017-2024
German Centre for Cardiovascular Research
2019-2024
Universitätsklinikum Gießen und Marburg
2024
Philipps University of Marburg
2024
Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie
2019-2023
Zero to Three
2023
Wildlife Information Liaison Development
2018
University Hospital of Zurich
2014-2015
Universitätsklinikum Erlangen
2014
Extracorporeal membrane oxygenation (ECMO) is considered a life-saving treatment option for patients in cardiogenic shock or cardiac arrest undergoing cardiopulmonary resuscitation (CPR) due to acute pulmonary embolism (PE). We sought analyze use and outcome of ECMO with without adjunctive strategies PE.We retrospectively analyzed data on patient characteristics, treatments, in-hospital outcomes all PE (ICD-code I26) Germany between 2005 2018.At total 1,172,354 were hospitalized PE; those,...
Sodium-glucose cotransporter 2 inhibitors are believed to improve cardiac outcomes due their osmotic diuretic potential. The goal of this study was test the hypothesis that vasopressin-driven urine concentration overrides effect glucosuria induced by dapagliflozin treatment. DAPA-Shuttle1 (Hepato-renal Regulation Water Conservation in Heart Failure Patients With SGLT-2 Inhibitor Treatment) a single-center, double-blind, randomized, placebo-controlled trial, which patients with chronic heart...
We have reported earlier that a high salt intake triggered an aestivation-like natriuretic-ureotelic body water conservation response lowered muscle mass and increased blood pressure. Here, we tested the hypothesis similar adaptive occurs in experimental chronic renal failure.In four subsequent experiments Sprague Dawley rats, used surgical 5/6 reduction (5/6 Nx) to induce failure. studied solute excretion 24-hour metabolic cage experiments, pressure by radiotelemetry, adjustment liver...
Abstract Aim Recent evidence suggests that arterial hypertension could be alternatively explained as a physiological adaptation response to water shortage, termed aestivation, which relies on complex multi‐organ metabolic adjustments prevent dehydration. Here, we tested the hypothesis chronic loss across diseased skin leads similar adaptive conservation responses observed in experimental renal failure or high salt diet. Methods We studied mice with keratinocyte‐specific overexpression of...
Traffic noise may play an important role in the development and deterioration of ischaemic heart disease. Thus, we sought to determine mechanisms cardiovascular dysfunction inflammation induced by aircraft a mouse model myocardial infarction (MI) humans with incident MI.C57BL/6J mice were exposed alone (average sound pressure level 72 dB; peak 85 dB) for up 4 days, resulting pro-inflammatory aortic gene expression myeloid cell adhesion/diapedesis pathways. The promoted adhesion infiltration...
We examined the cardiovascular effects of celiac disease (CeD) in a humanized mouse model, with focus on vascular inflammation, endothelial dysfunction, and oxidative stress. NOD.DQ8 mice genetically predisposed to CeD were subjected diet regime oral gavage induce (gluten group vs. control). tested function, confirmed indicators, evaluated inflammation stress various tissues. Plasma proteome profiling was also performed. markers gluten group, indicating increased blood pressure impaired...
Abstract Aims Heart failure (HF) ensuing myocardial infarction (MI) is characterized by the initiation of a systemic inflammatory response. We aimed to elucidate impact myelomonocytic cells and their activation angiotensin II on vascular endothelial function in mouse model HF after MI. Methods results was induced male C57BL/6J mice permanent ligation left anterior descending coronary artery. Compared sham, had significantly impaired accompanied enhanced mobilization Sca-1+c-Kit+...
Despite major advances in acute interventions for myocardial infarction (MI), adverse cardiac remodeling and excess fibrosis after MI causing ischemic heart failure (IHF) remain a leading cause of death worldwide. Here we identify profibrotic coagulation signaling pathway that can be targeted improved function following with persistent ischemia. Quantitative phosphoproteomics tissue revealed an upregulated mitogen-activated protein kinase (MAPK) human IHF. Intervention this trametinib...
The neutrophil recruiting cytokine Interleukin-17A (IL-17A) is a key component in vascular dysfunction and arterial hypertension. Moreover, IL-17A has central role for the infiltration of myeloid cells into wall Angiotensin II-induced inflammation. intention our study was to analyze impact T cell-derived on hypertension, function, Chronic overexpression (CD4-IL-17Aind/+ mice) resulted elevated reactive oxygen species peripheral blood significant compared control mice. seen CD4-IL-17Aind/+...
Background Psoriasis is a frequent chronic inflammatory cytokine‐mediated skin disease and was identified to be an independent risk factor for the occurrence of myocardial infarction (MI). However, data about impact psoriasis on mortality other in‐hospital adverse events in setting MI are sparse inconsistent. Methods Results The nationwide German inpatient sample years 2005 2016 used statistical analysis. Hospitalized patients with were stratified presence investigated. Overall, 3 307 703...
Intensive care units (ICU) capacities are one of the most critical determinants in health-care management COVID-19 pandemic. Therefore, we aimed to analyze ICU-admission and case-fatality rate as well characteristics outcomes patient admitted ICU order identify predictors associated conditions for worsening this ill patient-group.We used German nationwide inpatient sample all hospitalized patients with confirmed diagnosis Germany between January December 2020. All infection during year 2020...
The cytokine interleukin-6 (IL-6) plays a central role in the inflammation cascade as well cardiovascular disease progression. Since myeloid cells are primary source of IL-6 formation, we aimed to generate mouse model study cell-derived vascular disease.
To investigate the contemporary use of extracorporeal membrane oxygenation (ECMO) in conjunction with reperfusion strategies high-risk pulmonary embolism (PE).
Summary Increased consumption of sodium is a risk factor for hypertension and cardiovascular diseases. In vivo studies indicated that high dietary may have direct negative influence on endothelium. We investigated the effects endothelial activation during early steps atherogenesis. Endothelial cells (HUVECs) grown in model arterial bifurcations were exposed to shear stress presence normal or (+ 30 mmol/l) sodium. Adherent THP-1 cells, adhesion molecule expression quantified. Sodium channel...
Aims: Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a cornerstone of drug therapy after myocardial infarction (MI) and improve left ventricular function survival. We aimed to elucidate the impact early treatment with ACE inhibitor ramipril on hematopoietic response MI, as well chronic systemic vascular inflammation. Methods Results: In mouse model induced by permanent ligation anterior descending artery, immediate initiation (10 mg/k/d via drinking water) reduced cardiac...
Abstract Objective parameters to quantify psoriatic inflammation are needed for interdisciplinary patient care, as well preclinical experimental models. This study evaluates neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) in psoriasis patients five murine models of psoriasis-like skin disease based on topical imiquimod application overexpression IL-17A under different promotors. We performed a single-center prospective observational German population, investigating...
Aims: Patients suffering from viral pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are at risk of developing distress (ARDS). ARDS is a serious complication COVID-19 that requires early recognition and comprehensive management. Little known about the concomitant prevalence both entities in Germany. Thus, we sought to analyze predictors regional trends case fatality patients with Methods: We analyzed data on characteristics, comorbidities...
Pulmonary embolism (PE) is a potentially life-threatening condition. Admission and treatment in the intensive care unit (ICU) an important element critically ill PE patients.
Abstract Aims Assessment of endothelial function in humans by measuring flow-mediated dilation (FMD) risk-stratifies individuals with established cardiovascular disease, whereas its predictive value is limited primary prevention. We therefore aimed to establish and evaluate novel markers FMD at the population level. Methods results In order identify targets that were negatively correlated investigate their contribution vascular function, we performed a genome-wide association study (GWAS)...
<b><i>Background:</i></b> An atherosclerotic disease burden sufficient to put lung transplant candidates at risk for end-organ after transplantation is considered be a relative contraindication transplantation. <b><i>Objectives:</i></b> The aim of this study was assess our current practice cardiac workup by coronary angiography in ≥50 years age. <b><i>Methods:</i></b> We retrospectively analyzed 50 consecutive age which...
Psoriasis is an immune-mediated inflammatory skin disease driven by interleukin-17A (IL-17A) and associated with cardiovascular dysfunction. We used a severe psoriasis mouse model of keratinocyte IL-17A overexpression (K14-IL-17Aind/+ , IL-17Aind/+ control mice) to investigate the activity neutrophils potential cellular interconnection between vasculature. Levels dermal reactive oxygen species (ROS) their release were measured lucigenin-/luminol-based assays, respectively. Quantitative...
(1) Background: Knowledge about predictors for the long-time patency of recanalized chronic total coronary occlusions (CTOs) is limited. Evidence from invasive follow-up in absence acute syndrome (routine surveillance angiography) scarce. (2) Methods: In a monocentric-retrospective analysis, we obtained baseline as well periprocedural data patients undergoing routine follow-up. We defined target vessel failure (TVF) combined primary endpoint, consisting re-occlusion, restenosis, and...