A5016915411- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal motility and disorders
- Advanced X-ray and CT Imaging
- Cardiovascular Function and Risk Factors
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Advanced Radiotherapy Techniques
- Cardiovascular Disease and Adiposity
- Atomic and Subatomic Physics Research
- Bone health and osteoporosis research
- Radiation Dose and Imaging
- Medical Image Segmentation Techniques
- Infectious Diseases and Tuberculosis
- Nutrition and Health in Aging
- Cardiac Valve Diseases and Treatments
- Systemic Sclerosis and Related Diseases
- Cardiovascular Effects of Exercise
- Cardiac Arrhythmias and Treatments
- Adipose Tissue and Metabolism
- Music Therapy and Health
- Thermoregulation and physiological responses
- Hepatocellular Carcinoma Treatment and Prognosis
A*STAR-NUS Clinical Imaging Research Centre
2015-2023
Bournemouth University
2021-2023
National University of Singapore
2017-2023
Agency for Science, Technology and Research
2015-2019
Guy's and St Thomas' NHS Foundation Trust
2014
University of Nottingham
2007-2013
King's College London
2009-2011
King's College Hospital
2005-2009
King's College School
2008
Queens University
2008
Background: Deficits characteristic of attention deficit/hyperactivity disorder (ADHD), including poor and inhibitory control, are at least partially alleviated by factors that increase engagement attention, suggesting a hypodopaminergic reward deficit. Lapses associated with attenuated deactivation the default mode network (DMN), distributed brain system normally deactivated during tasks requiring to external world. Task-related DMN has been shown be in ADHD relative controls. We...
Sodium-glucose cotransporter 2 inhibitors are believed to improve cardiac outcomes due their osmotic diuretic potential. The goal of this study was test the hypothesis that vasopressin-driven urine concentration overrides effect glucosuria induced by dapagliflozin treatment. DAPA-Shuttle1 (Hepato-renal Regulation Water Conservation in Heart Failure Patients With SGLT-2 Inhibitor Treatment) a single-center, double-blind, randomized, placebo-controlled trial, which patients with chronic heart...
Cardiovascular magnetic resonance (CMR) allows non-invasive phase contrast measurements of flow through planes transecting large vessels. However, some clinically valuable applications are highly sensitive to errors caused by small offsets measured velocities if these not adequately corrected, for example the use static tissue or phantom correction offset error. We studied severity uncorrected velocity across sites and CMR systems. In a multi-centre, multi-vendor study, breath-hold...
To investigate the association between intra-abdominal adiposity and individual components of metabolic syndrome (MS) in adolescent males females.Cross-sectional study a population-based cohort.Saguenay Youth Study, Quebec, Canada.A total 324 adolescents, aged 12 to 18 years.Measures were compared females with "high" or "low" fat (IAF).Intra-abdominal was quantified magnetic resonance imaging. Primary outcome measures blood pressure (BP) fasting serum glucose, insulin, lipids, C-reactive...
Substantial water fluxes across the small intestine occur during digestion of food, but so far measuring these has required invasive intubation techniques. This paper describes a non-invasive magnetic resonance imaging (MRI) technique for bowel content which been validated using naso-duodenal infusion. Eighteen healthy volunteers were intubated, with tube position being verified by MRI. After baseline MRI scan, each volunteer had eight 40 ml boluses non-absorbable mannitol and saline...
An emerging body of evidence indicates that short-term immersion in cold water facilitates positive affect and reduces negative affect. However, the neural mechanisms underlying these effects remain largely unknown. For first time, we employed functional magnetic resonance imaging (fMRI) to identify topological clusters networks coupled with behavioural changes after a 5 min cold-water immersion. Perceived were associated feeling more active, alert, attentive, proud, inspired, whilst...
Eddy current induced velocity offsets are of concern for accuracy in cardiovascular magnetic resonance (CMR) volume flow quantification. However, currently known theoretical aspects eddy behavior have not led to effective guidelines the optimization quantification sequences. This study is aimed at identifying correlations between protocol parameters and resulting error clinical CMR measurements a multi-vendor study. Nine 1.5T scanners three different types/vendors were studied. Measurements...
The emptying of the gall bladder in response to feeding is pivotal for digestion fat, but role various food ingredients contracting postprandially not well understood. We hypothesized that different ingredients, when consumed, will have a effect on stimulating emptying. To investigate this we designed two randomized, investigator-blind, cross-over studies healthy subjects using magnetic resonance imaging (MRI) measure volumes serially and non-invasively. Study 1: exploratory study evaluating...
This study aimed to investigate image quality for a comprehensive set of isotopes ((18)F, (11)C, (89)Zr, (124)I, (68)Ga, and (90)Y) on 2 clinical scanners: PET/CT scanner PET/MR scanner.Image spatial resolution were tested according NU 2-2007 the National Electrical Manufacturers Association. An image-quality phantom was used measure contrast recovery, residual bias in cold area, background variability. Reconstruction methods available scanners compared, including point-spread-function...
To compare Dixon-based MRI techniques for intramuscular fat quantification at 3 T with MR spectroscopy (MRS) in vitro and vivo.
This study aimed to compare the associations of positron emission tomography (PET), magnetic resonance (MR), and infrared thermography (IRT) imaging modalities with energy expenditure (EE) after brown adipose tissue (BAT) activation using capsinoid ingestion cold exposure.Twenty participants underwent PET-MR, IRT imaging, whole-body calorimetry exposure. Standardized uptake values (SUV) fat fraction (FF) supraclavicular regions were estimated. The anterior temperature (Tscv) from at baseline...
The diagnosis of osteoporosis is mainly based on clinical examination and bone mineral density assessments. present pilot study compares the plasma lipid polar metabolite profiles in blood 95 Singaporean-Chinese (SC) menopausal women with normal low (BMD) using an untargeted metabolomic approach. primary finding this was association between lipids femoral neck BMD SC women. Twelve were identified to be associated by orthogonal partial least squares (OPLS) model. Plasma concentrations eight...
The aim of the study was to adapt methodology established for dynamic CT measurements hepatic perfusion index (HPI) MRI, and assess potential role MRI HPI in detecting regional alterations liver between patients with colorectal metastases normal controls. evaluated from serial T(1) volume acquisitions acquired over course a Gd-DTPA bolus injection. Time-course data regions interest liver, spleen aorta were used calculate HPI; control subjects compared known metastases. Significant...
Head motion occurring during brain PET studies leads to image blurring and bias in measured local quantities. The objective of this work was implement a correction method for data acquired with the mMR synchronous PET/MR scanner. Methods: A list-mode-based motion-correction approach has been designed. developed rebinner chronologically reads recorded events from Siemens list-mode file, applies estimated geometric transformations, frames detected counts into sinograms. rigid-body parameters...
Aging | doi:10.18632/aging.202374. Lei Feng, Rafael Romero-Garcia, John Suckling, Jasmine Tan, Anis Larbi, Irwin Cheah, Glenn Wong, Maurine Tsakok, Bernard Lanskey, Darius Lim, Jialiang Li, Joanna Yang, Benjamin Goh, Tristan Gwee Chen Teck, Allan Ho, Xiu Wang, Jin-Tai Yu, Can Zhang, Crystal Michelle Chua, Junhua J Totman, Caroline Marie Loh, Roger Foo, Chay Hoon Lee Gan Rathi Mahendran, Brian K. Kennedy, Ee-Heok Kua
5-HT(3) antagonists have been shown to be effective in relieving the symptoms of irritable bowel syndrome with diarrhoea (IBS-D). Using a recently validated magnetic resonance imaging (MRI) method, we demonstrated reduced fasting small water content (SBWC) IBS-D associated accelerated transit. We hypothesized that slowing transit ondansetron would lead an increase SBWC by inhibiting motility.To assess effects compared placebo healthy volunteers on and motility two different groups subjects,...
Metabolic disruption commonly follows Anterior Cruciate Ligament Reconstruction (ACLR) surgery. Brief exposure to low amplitude and frequency pulsed electromagnetic fields (PEMFs) has been shown promote in vitro vivo murine myogeneses via the activation of a calcium-mitochondrial axis conferring systemic metabolic adaptations. This randomized-controlled pilot trial sought detect local changes muscle structure function using MRI, metabolism plasma biomarker analyses resulting from ACLR, with...
Abstract Background Mitochondrial dysfunction has been implicated in sarcopenia. 31 P magnetic resonance spectroscopy (MRS) enables non‐invasive measurement of adenosine triphosphate (ATP) synthesis rates to probe mitochondrial function. Here, we assessed muscle energetics older sarcopenic and non‐sarcopenic men compared with biopsy‐derived markers Methods Twenty Chinese sarcopenia (SARC, age = 73.1 ± 4.1 years) 19 healthy aged sex‐matched controls (CON, 70.3 4.2 underwent assessment...