A5027991480- Sodium Intake and Health
- Thermoregulation and physiological responses
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Hepatitis C virus research
- Renin-Angiotensin System Studies
- Hepatitis B Virus Studies
- Electrolyte and hormonal disorders
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Dietary Effects on Health
- Ion Transport and Channel Regulation
- Chronic Kidney Disease and Diabetes
- Nutrition and Health in Aging
- Viral-associated cancers and disorders
- Apelin-related biomedical research
- Growth Hormone and Insulin-like Growth Factors
- Abdominal vascular conditions and treatments
- Pancreatic function and diabetes
- Renal function and acid-base balance
- Erythropoietin and Anemia Treatment
Duke-NUS Medical School
2022-2024
Kagawa University
2018-2023
National University of Singapore
2023
Jikei University School of Medicine
2015-2021
Pharmac
2021
Saitama Red Cross Hospital
2016-2017
Sodium-glucose cotransporter 2 inhibitors are believed to improve cardiac outcomes due their osmotic diuretic potential. The goal of this study was test the hypothesis that vasopressin-driven urine concentration overrides effect glucosuria induced by dapagliflozin treatment. DAPA-Shuttle1 (Hepato-renal Regulation Water Conservation in Heart Failure Patients With SGLT-2 Inhibitor Treatment) a single-center, double-blind, randomized, placebo-controlled trial, which patients with chronic heart...
We have reported earlier that a high salt intake triggered an aestivation-like natriuretic-ureotelic body water conservation response lowered muscle mass and increased blood pressure. Here, we tested the hypothesis similar adaptive occurs in experimental chronic renal failure.In four subsequent experiments Sprague Dawley rats, used surgical 5/6 reduction (5/6 Nx) to induce failure. studied solute excretion 24-hour metabolic cage experiments, pressure by radiotelemetry, adjustment liver...
The kidneys are the major organs for erythropoietin (EPO) production in adults, and thus, kidney damage results reduced EPO levels anemia. Inhibitors of Hypoxia-inducible factor-prolyl hydroxylase domain-containing protein (HIF-PHD) awaited as new therapeutic options renal It can be predicted that most patients who receive HIF-PHD inhibitors have dysfunction a cause Therefore, present study, we investigated effects inhibitor molidustat on anemia when initiated after onset Male C57BL/6J mice...
Acute kidney injury (AKI) is a global public health concern with high mortality and morbidity. In ischemic reperfusion (IRI), main cause of AKI, the brush border membrane S3 proximal tubules (PT) lost to tubular lumen. How injured reconstitute lipids during renal recovery not known. Here, we identified Mfsd2a, sodium-dependent lysophosphatidylcholine (LPC) transporter, be expressed specifically in basolateral PT. Using an vivo activity probe for transport was found specific Mice...
Abstract A fixed‐dose formula that combines Ombitasvir (OBV), Paritaprevir (PTV) and Ritonavir (RTV) has been launched into the field of anti‐HCV therapy in Japan for patients infected with HCV genotypes 1 2 2015. However, little is yet known as to efficacy safety this novel on maintenance haemodialysis (HD). The present report describes a preliminary experience 10 (five males five females) who underwent HD. All them had genotype 1b, without having resistance‐associated variants at Y93 or...
The captopril challenge test (CCT) is the major confirmatory for primary aldosteronism (PA), and frequently carried out because of its convenience. However, it presents false-negative results with a certain probability, as there are many criteria CCT, not concluded yet which to use.A total 71 PA patients were evaluated. We compared CCT-positive CCT-negative in following three criteria: plasma aldosterone/renin ratio (ARR) >200 after CCT (criterion 1); aldosterone concentration (PAC) >120...
Background: Textbook teaching pretends that Na + -driven extracellular fluid and blood volume expansion may cause hypertension. We tested the alternative hypothesis, namely K loss-driven intracellular contraction causes Methods: effect of deoxycorticosterone acetate (DOCA; 25 mg pellet) in mice on low diet (0.02-0.03%) without (tap water), or with their drinking water (1% NaCl 1.44% NaHCO 3 ). measured BP radio-telemetry, analysed body , content 2, 6, 12 days after initiation DOCA treatment....
TAFRO症候群は，血小板減少（thrombocytopenia），腔水症（anasarca），発熱（fever），骨髄線維症（myelofibrosis），腎機能障害（renal dysfunction），臓器腫大（organomegaly）を特徴とする．症例は66歳，男性．7カ月前に血小板数減少を指摘され，約1カ月前より腹痛，胸腹水貯留が生じた．前医入院後に腎機能障害が出現し，当院転院となり，TAFRO症候群と診断した．比較的急峻な経過を辿るもステロイドおよびシクロスポリンによる治療で改善した．血小板減少を伴う腎機能障害の鑑別にTAFRO症候群を挙げることが肝心である．
The nonsteroidal mineralocorticoid receptor blocker esaxerenone is effective in reducing blood pressure (BP). In this study, we investigated esaxerenone-driven sodium homeostasis and its association with changes BP Dahl salt-sensitive (DSS) hypertensive rats. the different experimental setups, evaluated by a radiotelemetry system, was determined an approach of intake (food intake) excretion (urinary excretion) DSS rats low-salt diet (0.3% NaCl), high-salt (HSD, 8% HSD plus 0.001% (w/w),...
Introduction: We have recently reported that high salt intake induces the energy-intensive nature of hepatic urea osmolyte production accompanied decrease in heart rate (HR). These findings suggest decreases sympathetic nerve activity to reduce cardiovascular energy expenditure for production. Therefore, we examined effects on renal (RSNA) by using a radiotelemetry system rats. Methods: inserted into male Sprague Dawley (SD) rats recording RSNA and HR. After 2 weeks recovery, fed 0.3% NaCl...
Hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitors were developed for treatment of renal anemia. Patients applicable HIF-PHD inhibitor experience complications such as chronic kidney disease, whereby water and electrolyte homeostasis is disrupted. The effects hypoxia-inducible stabilization on salt accumulation in the setting reduced function remain unclear. In present study, we investigated effect a inhibitor, molidustat, distribution excretion rats with subtotal...
非閉塞性腸管虚血症 (non-occlusive mesenteric ischemia : NOMI) は, 腸間膜動静脈に閉塞や血栓を認めない腸管虚血症である. 血液透析 (HD) 患者におけるNOMI発症率はまれだが, 非透析患者に比べて100倍程度増加し, かつ, 致死率が極めて高く, 迅速な診断と加療を要する. 血圧低下を契機にNOMIを発症したHD2症例を経験した. 症例1はHD歴2か月の52歳男性で低左心機能に伴う低血圧を契機に発症, 症例2はHD歴5年の88歳女性で出血に伴う低血圧を契機に発症した. NOMI発症誘因として全身の低灌流状態に伴う血管攣縮が示唆されている. またHD患者のprofileとNOMIのrisk factorは酷似している. NOMIに特異的症状や検査所見はなく, HD中の血圧低下に腹痛を併発した場合にNOMIを念頭におくことが重要であり, 簡便に施行できるdynamic造影CT検査が診断に有用である. NOMIは予後不良であり, 発症予防として, 透析間体重増加の管理などの患者教育およびHD中の血圧管理が重要である.
Objective: Mineralocorticoid receptor (MR) activation is known to reduce renal Na+ elimination and increase body fluid, resulting in arterial hypertension. We have reported earlier that high salt intake, chronic failure psoriasis occur blood pressure increases initiated by water loss. Here we tested the hypothesis DOCA treatment induces a similar adaptive conservation response also causes Design method: Male C57BL/6J mice on low-salt diet (<0.1% NaCl) were divided into four groups: tap...
Objective: We reported that high salt intake decreases heart rates via a reduction in renal sympathetic activity normal Sprague Dawley rats to compensate for salt-driven catabolism. also revealed Dahl salt-sensitive (DSS) cannot reduce during because of the abnormal activation nerve activity. It is known are negatively associated with life span. Therefore, we hypothesized denervation ontributes long span salt-fed DSS rats. Design and Method: (Experiment 1) performed (n = 9) or sham operation...
Objective: Although previous studies have demonstrated the pathophysiological basis of hypertension in basic and clinical sciences, decisive mechanism essential remains to be clarified. We recently reported that 5/6 nephrectomized rats exhibited renal water loss due impaired concentration ability triggered suppression transepidermal (TEWL). This skin conservation was achieved by vasoconstriction-mediated reduction vascular mass, which increased blood pressure rats. In this study, we examined...
Recent studies suggest skin vasoconstriction and sodium (Na + ) accumulation are associated with hypertension. The has a localized renin-angiotensin system (RAS), key regulator of blood pressure (BP), but its functional role remains unclear. This study aims to investigate the RAS in Skin tissue from 32 individuals, including patients hypertension, was used evaluate association between component expression office BP. Among components, ATRAP (type-1 angiotensin II (Ang II) receptor...