A5028819689- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Blood Pressure and Hypertension Studies
- Diabetes Treatment and Management
- Receptor Mechanisms and Signaling
- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Adipose Tissue and Metabolism
- Sodium Intake and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Ion Transport and Channel Regulation
- Nephrotoxicity and Medicinal Plants
- Potassium and Related Disorders
- Dialysis and Renal Disease Management
- Lipoproteins and Cardiovascular Health
- Diabetes Management and Research
- Eicosanoids and Hypertension Pharmacology
- Heart Failure Treatment and Management
- Apelin-related biomedical research
- Pharmacology and Obesity Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- COVID-19 Clinical Research Studies
Yokohama City University
2016-2025
Kirin (Japan)
2023
Naval Hospital Yokosuka Japan
2023
Yokohama Minami Kyosai Hospital
2023
Yokohama City University Hospital
2023
RELX Group (United States)
2020
Akita University
2010-2014
Kumamoto University
2013
Tokyo Medical and Dental University
2013
Tulane University
2013
We reported previously that ATP2B1 was one of the genes for hypertension receptivity in a large-scale Japanese population, which has been replicated recently Europeans and Koreans. encodes plasma membrane calcium ATPase isoform 1, plays critical role intracellular homeostasis. In addition, it is suggested major vascular smooth muscle contraction. Because knockout (KO) mouse embryo-lethal, we generated mice with cell-specific KO using Cre-loxP system to clarify relationship between...
Abstract Tumor necrosis factor (TNF)-α is a potent mediator of inflammation and involved in the pathophysiology chronic kidney disease (CKD). However, effects TNF-α inhibition on progression fibrosis have not been fully elucidated. We examined by etanercept (ETN) mice with aristolochic acid (AA) nephropathy as model fibrosis. C57BL/6 J were administered AA for 4 weeks, followed 4-week remodeling period. The exhibited fibrosis, functional decline, albuminuria concomitant increases renal mRNA...
Activation of tissue angiotensin II (Ang II) type 1 receptor (AT1R) plays an important role in the development vascular remodelling. We have shown that AT1R-associated protein (ATRAP/Agtrap), a specific binding AT1R, functions as endogenous inhibitor to prevent pathological activation renin-angiotensin system. In this study, we investigated effects ATRAP on Ang II-induced remodelling.Transgenic (Tg) mice with pattern aortic vascular-dominant overexpression were obtained, and or vehicle was...
Angiotensin II type 1 receptor (AT1R)–associated protein (ATRAP) promotes AT1R internalization along with suppression of pathological activation tissue signaling. However, the functional significance ATRAP in renal sodium handling and blood pressure regulation under stimuli is not fully resolved. Here we show mice a gene-targeted disruption was comparable to that wild-type at baseline. ATRAP-knockout mice, angiotensin II–induced hypertension exacerbated extent positive balance increased by...
Abstract Background We investigated the effects of sacubitril/valsartan, a first-in-class angiotensin receptor neprilysin inhibitor (ARNI), on 24-hour blood pressure (BP) and safety for 12 weeks in Japanese patients with non-dialysis advanced chronic kidney disease (CKD). Methods conducted prospective, single-arm exploratory study. Patients CKD stage G4-5 (estimated glomerular filtration (eGFR) <30 mL/min/1.73 m2) who did not achieve their BP goals blocker (ARB) administration, were...
We cloned a novel molecule interacting with angiotensin II type 1 receptor, which we named ATRAP (for receptor-associated protein). Previous in vitro studies showed that significantly promotes constitutive internalization of the receptor and further attenuates II-mediated hypertrophic responses cardiomyocytes. The present study was designed to investigate putative functional role cardiac hypertrophy by infusion vivo. first examined effect on endogenous expression heart C57BL/6J wild-type...
We have previously shown that angiotensin II type 1 receptor-associated protein (ATRAP/ Agtrap ) interacts with the receptor and promotes constitutive internalization of so as to inhibit pathological activation its downstream signaling but preserve baseline physiological activity. The present study was designed investigate role renal ATRAP in II–dependent hypertension. generated transgenic mice dominantly expressing tubules, including distal tubules. exhibited no significant change blood...
Background Metabolic disorders with visceral obesity have become a major medical problem associated the development of hypertension, type 2 diabetes, and dyslipidemia and, ultimately, life‐threatening cardiovascular renal diseases. Adipose tissue dysfunction has been proposed as cause obesity‐related metabolic disorders, moving toward proinflammatory phenotype. Methods Results Here we first report that adipose tissues from patients mice exhibit decreased expression ATRAP / Agtrap , which is...
The renin-angiotensin system has a pivotal role in the pathophysiology of visceral obesity. Angiotensin II type 1 receptor (AT1R) is major player signal transduction system, and overactivation this signaling contributes to progression We have shown that AT1R-associated protein (ATRAP) promotes AT1R internalization from cell surface into cytoplasm along with suppression tissue signaling. In study, we examined whether enhancement adipose ATRAP expression could efficiently prevent diet-induced...
Abstract Background The Y-AIDA study was designed to investigate the renal- and home blood pressure (BP)-modulating effects of add-on dapagliflozin treatment in Japanese individuals with type 2 diabetes mellitus (T2DM) albuminuria. Methods We conducted a prospective, multicenter, single-arm study. Eighty-six patients T2DM, HbA1c 7.0–10.0%, estimated glomerular filtration rate (eGFR) ≥ 45 mL/min/1.73 m , urine albumin-to-creatinine ratio (UACR) 30 mg/g creatinine (gCr) were enrolled, 85 these...
The kidney is one of the most susceptible organs to age-related impairments. Generally, renal aging accompanied by fibrosis, which final common pathway chronic diseases. Aristolochic acid (AA), a nephrotoxic agent, causes AA nephropathy (AAN), characterized progressive fibrosis and functional decline. Although associated with aging, whether induces remains unclear. aim present study investigate potential use AAN as model aging. Here, we examined senescence-related factors in models...
To compare the therapeutic effects of glucose-dependent insulinotropic polypeptide (GIP)/ glucagon-like peptide-1 receptor agonists (GLP-1RAs) or GLP-1RAs in Japanese patients with type 2 diabetes (T2D).We systematically searched PubMed, MEDLINE, EMBASE, and Cochrane Library up to July 2023. Randomized controlled trials (RCTs) that compared GIP/GLP-1RAs T2D were selected. A network meta-analysis was conducted indirectly treatments, focusing on efficacy reducing glycated haemoglobin (HbA1c)...
Abstract We evaluated the effectiveness of a mobile health (mHealth) intervention for diabetic kidney disease patients by conducting 12-month randomized controlled trial among 126 type 2 diabetes mellitus with moderately increased albuminuria (urinary albumin-to-creatinine ratio (UACR): 30-299 mg/g creatinine) recruited from eight clinical sites in Japan. Using Theory Planned Behavior (TPB) behavior change theory framework, provides detailed information order to improve patient control over...
We have recently cloned a novel molecule that interacts with the angiotensin II type 1 receptor (AT1R)-associated protein (ATRAP). In this study, we tested hypothesis ATRAP modulates II-induced responses in vascular smooth muscle cells. The results of immunoprecipitation and bioluminescence resonance energy transfer assay demonstrated direct interaction between AT1R at baseline showed enhanced these proteins >2-fold. immunofluorescence analysis also >65% constitutively colocalized an...