A5043931842- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Thyroid Disorders and Treatments
- Mobile Health and mHealth Applications
- Diabetes Management and Research
- Thyroid Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Physical Activity and Health
- Pregnancy and preeclampsia studies
- Telemedicine and Telehealth Implementation
- Cardiovascular Health and Risk Factors
- Diabetes and associated disorders
- Digital Mental Health Interventions
- Behavioral Health and Interventions
- Ophthalmology and Eye Disorders
- COVID-19 and healthcare impacts
- Diet, Metabolism, and Disease
- Blood Pressure and Hypertension Studies
- Regulation of Appetite and Obesity
- Neurological and metabolic disorders
- Bone health and osteoporosis research
- Ultrasound Imaging and Elastography
- Muscle and Compartmental Disorders
- Medication Adherence and Compliance
- RNA modifications and cancer
University of Tokyo Hospital
2020-2025
Ito Hospital
2024-2025
National Center For Child Health and Development
2023-2025
Kyoto University
2017-2021
Kurashiki Central Hospital
2014-2016
The aim of this study was to identify the main influencing factor shear wave velocity (SWV) kidneys measured by acoustic radiation force impulse elastography.The SWV in 14 healthy volunteers and 319 patients with chronic kidney disease. estimated glomerular filtration rate calculated serum creatinine concentration age. As an indicator arteriosclerosis large vessels, brachial-ankle pulse 183 patients.Compared degree interobserver intraobserver deviation, a variance values observed Shear right...
Gastric inhibitory polypeptide receptor (GIPR) directly induces energy accumulation in adipose tissue vitro. However, the importance of direct effect GIPR signaling on vivo remains unclear. In current study, we generated tissue–specific knockout (GIPRadipo−/−) mice and investigated actions GIP tissue. Under high-fat diet (HFD)-fed conditions, GIPRadipo−/− had significantly lower body weight lean mass compared with those floxed (GIPRfl/fl) mice, although fat volume was not different between...
Free fatty acid receptors GPR120 and GPR40 are involved in the secretion of gut hormones. expressed enteroendocrine K cells, their activation induces incretin glucose-dependent insulinotropic polypeptide (GIP). However, role these fat-induced GIP vivo associated mechanisms unclear. In this study, we investigated corn oil–induced GPR120-knockout (GPR120−/−) GPR40-knockout (GPR40−/−) mice. Oil-induced was reduced by 50% 80% GPR120−/− GPR40−/− mice, respectively, compared with wild-type This...
Abstract We evaluated the effectiveness of a mobile health (mHealth) intervention for diabetic kidney disease patients by conducting 12-month randomized controlled trial among 126 type 2 diabetes mellitus with moderately increased albuminuria (urinary albumin-to-creatinine ratio (UACR): 30-299 mg/g creatinine) recruited from eight clinical sites in Japan. Using Theory Planned Behavior (TPB) behavior change theory framework, provides detailed information order to improve patient control over...
Abstract Aims/Introduction Glucagon‐like peptide‐1 ( GLP ‐1) secreted from enteroendocrine L cells is an incretin that potentiates insulin secretion and already applied in therapies for type 2 diabetes. However, detailed examination of throughout the gastrointestinal tract remains unclear, because difficulties purifying scattered other cells. In present study, we identified characteristics upper small intestine UI ), lower LI ) colon using glucagon‐green fluorescent protein‐expressing mice...
Incretin hormone glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide (GIP) plays a key role in high-fat diet-induced obesity and insulin resistance. GIP is strongly secreted from enteroendocrine K cells by oil ingestion. G protein-coupled receptor (GPR)120 GPR40 are two major receptors for long chain fatty acids, expressed cells. In the present study, we investigated effect of on oil-induced secretion using GPR120- GPR40-double knockout (DKO) mice.Global mice GPR120...
Agranulocytosis is a serious adverse effect of methimazole (MMI) and propylthiouracil (PTU), although there have been reports suggesting dose-dependent incidence in relation to both drugs, the evidence has not conclusive. The objective our study was determine whether incidences agranulocytosis induced by MMI PTU exhibit dose-dependency. subjects were 27,784 patients with untreated Graves' disease, 22,993 whom on an antithyroid drug treatment regimen for more than 90 days. Within this subset,...
There are few reports of subacute thyroiditis (SAT) during pregnancy. This study aimed to clarify the clinical characteristics SAT in pregnant patients.
<sec> <title>UNSTRUCTURED</title> Reduced or delayed medical follow-ups have been reported during the COVID-19 pandemic, which may lead to worsening clinical outcomes for patients with diabetes. The Japanese government granted special permission institutions use telephone consultations and other remote communication modes pandemic. We aimed evaluate changes in frequency of outpatient consultations, glycemic control, renal function among type 2 diabetes before This is a retrospective...
Abstract Purpose The purpose was to investigate i) whether the occurrence of newly diagnosed thyroid cancer is increased after radioactive iodine therapy (RAIT) for Graves’ disease (GD), and ii) following RAIT has poor prognosis. Methods A total 13,874 eligible patients with untreated GD were retrospectively analyzed. incidence rates developed by each treatment method evaluated using person-year method. Among 23,179 who underwent GD, including those recurrent or a history prior Logistic...
Pregnant women with Graves' disease (GD) who have undergone thyroidectomy or radioactive iodine therapy can high levels of thyroid-stimulating hormone (TSH) receptor antibodies, which are transferred to the fetus via placenta, posing a risk for fetal GD. This retrospective observational study, conducted at two high-level perinatal medical centers in Tokyo and Osaka, Japan, aimed identify predictors GD pregnant had therapy. In total, 65 were included, 79 singleton pregnancies fetuses...
Glucose-dependent insulinotropic polypeptide (GIP) is released during meals and promotes nutrient uptake storage. GIP receptor knockout mice are protected from diet induced weight gain thus antagonists have been proposed as a treatment for obesity. In this study, we assessed the role of in hyperphagia obesity metabolic abnormalities leptin deficient (Lepob/ob) mice. We crossbred GIP-GFP knock-in homozygous (GIPgfp/gfp) that complete knockout, heterozygous ob mutation (Lepob/+) to generate...
Both high-fat (HFD) and high-carbohydrate (ST) diets are known to induce weight gain. Glucose-dependent insulinotropic polypeptide (GIP) is secreted mainly from intestinal K cells upon stimuli by nutrients such as fat glucose, it potentiates glucose-induced insulin secretion. GIP well contribute HFD-induced obesity. In this study, we analyzed the effect of ST feeding on secretion metabolic parameters explore role in ST-induced wild-type (WT) receptor deficient ( GiprKO) mice were fed normal...
Long-chain triglycerides (LCTs) intake strongly stimulates GIP secretion from enteroendocrine K cells and induces obesity insulin resistance partly due to hypersecretion. In this study, we found that medium-chain (MCTs) inhibit after single LCT ingestion clarified the mechanism underlying MCT-induced inhibition of secretion. MCTs reduced CCK effect in wild-type (WT) mice, a agonist completely reversed vitro studies showed fatty acids (MCFAs) long-chain acid (LCFA)-stimulated increase...
Gastric inhibitory polypeptide (GIP) is an incretin secreted from enteroendocrine K cells and potentiates insulin secretion pancreatic β-cells. GIP also enhances long-chain triglyceride (LCT) diet-induced obesity resistance. Long-term intake of medium-chain (MCT) diet known to induce less body weight fat mass gain than that LCT diet. However, the effect MCT feeding on under diet-feeding condition are unknown. In this study, we evaluated single oil administration compared long-term in...
Background Diabetic kidney disease (DKD) is one of the main complications type 2 diabetes mellitus (T2DM). DKD a known risk factor for end-stage renal disease, cardiovascular and all-cause death. Effective intervention early-stage vital to slowing down progression improve prognoses. Mobile health (mHealth) reportedly effective in supporting patients’ self-care improving glycemic control, but impact mHealth on has yet be shown. Objective The purpose this study evaluate efficacy standard...
Fat accumulation with aging is a serious problem; glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide (GIP) an incretin that plays important role in fat accumulation. GIP receptor knockout mice show reduced mass and improved insulin sensitivity associated aging. Therefore, involved resistance However, age-related changes of secretion remain unclear. The present study aimed to elucidate enteroendocrine K cells using reporter [GIP-green fluorescent protein (GFP)...
Cholecystokinin (CCK) is secreted from enteroendocrine I cells in response to fat, carbohydrate, and protein ingestion. Gene expression of nutrient-sensing molecules remains unclear, primarily due the difficulty distinguishing intestinal epithelial vivo. In this study, we generated CCK reporter male mice which red fluorescence tdTomato (Tomato) produced by activation native murine Cck promoter. Fluorescence microscopy revealed presence Tomato-positive upper small intestine (SI), lower SI,...
High blood pressure (BP) and physical inactivity are the major risk factors for cardiovascular diseases. Mobile health is expected to support patients' self-management improving health; development of fully automated systems necessary minimize workloads care providers.The objective our study was evaluate preliminary efficacy, feasibility, perceived usefulness an intervention using a novel smartphone-based system (DialBetes Step) in increasing steps per day among workers with high BP.On basis...
Objective This study assessed the efficacy of machine learning in predicting thyrotoxicosis and hypothyroidism [thyroid-stimulating hormone >10.0 mIU/L] by leveraging age sex as variables integrating biochemical test parameters used Japan Society Health Evaluation Promotion (JHEP) Ningen Dock (JND). Methods Our included 20,653 untreated patients with Graves' disease, 3,435 painless thyroiditis, 4,266 healthy individuals, 18,937 Hashimoto's thyroiditis. Machine was conducted using Prediction...
A 37-year-old, never-smoker, pregnant woman diagnosed with Graves' disease who had stable thyroid eye (TED) before pregnancy presented aggravated proptosis and eyelid swelling at 13 weeks of pregnancy. Despite the administration local triamcinolone 3 cycles corticosteroid pulse therapy from 25 to 28 weeks, patient's visual acuity decline necessitated postpartum orbital decompression surgery. Although TSH receptor antibody (TRAb) levels decreased during mid- late term pregnancy, TED worsened....