A5014603629- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- Neuroendocrine Tumor Research Advances
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- BRCA gene mutations in cancer
- Parathyroid Disorders and Treatments
- Cancer Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Bone health and treatments
- Cancer-related Molecular Pathways
- Ovarian cancer diagnosis and treatment
- Radiation Dose and Imaging
- Bone health and osteoporosis research
- Salivary Gland Tumors Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Breast Cancer Treatment Studies
- Inflammatory Biomarkers in Disease Prognosis
- Vitamin D Research Studies
- Genetic Syndromes and Imprinting
- Pancreatic and Hepatic Oncology Research
Ito Hospital
2016-2025
Shibuya (Japan)
2015-2025
Akita University Hospital
2021
Nippon Medical School
2015
Yokohama City University
1988-2002
Keio University
1996-2002
Yokohama City University Medical Center
2002
Hiroshima University
1989-2001
Kawasaki Medical School
1992
Hiratsuka Kyosai Hospital
1989-1990
To determine the frequency and pattern of lymph node metastasis (LNM) from papillary thyroid microcarcinoma (PTMC) results dissection, to establish optimal strategy for neck dissection in these patients.Most PTMCs carry a favorable prognosis, but few present with palpable lymphadenopathy. Patients LNM are at risk nodal recurrence, although they do not have higher mortality. The PTMC well established.The 259 were analyzed according size location primary tumor. Of 259, 24 nodes underwent...
Most patients with thyroid carcinoma have a good prognosis. Due to the small number of fatal cases, it has not been clarified what conditions result in death for carcinoma. To provide appropriate management advanced patients, we analyzed causes 161 cases. Clinical characteristics and immediate (final) based on pathological were 62 anaplastic carcinomas 99 differentiated carcinomas. Single could be specified 55 patients. In remaining 106 respiratory insufficiency (43%) was most common...
Anaplastic thyroid carcinoma (ATC) is a malignancy with one of the highest fatality rates. Here we report retrospective study treatment and other factors associated its outcomes.The medical records 100 patients diagnosed ATC at Ito Hospital between 1993 2009 were reviewed pertinent information was extracted analyzed.There 80 women 20 men, their median age diagnosis 68 years (range, 41-90 years). Thirteen had history well-differentiated carcinoma. Six small focus within differentiated All...
Although lenvatinib is the preferred treatment for unresectable radioactive iodine-refractory differentiated thyroid cancer (RR-DTC), this agent exerts considerable toxicities, which can lead to frequent dose interruptions and modifications. The adoption of planned drug holidays has been recently suggested as one means minimizing or avoiding these severe adverse events. Our retrospective study demonstrated that appear be a promising strategy continuing lenvatinib. However, benefits in...
A high prevalence of the activating BRAF mutation, BRAFT1796A, is observed in adult papillary thyroid carcinomas (PTCs). The prognosis childhood PTCs generally fairly good despite fact that distant metastases are often documented these cases. To investigate differences between characteristics and PTCs, we analyzed both BRAFT1796A RAS mutations 31 Japanese 48 post-Chernobyl Ukrainian carcinomas. In cases, was found only one instance (3.2%), no were detected. subjects, 15 33 adolescent young...
Distant metastases are more common in patients with follicular thyroid carcinoma (FTC) than papillary carcinoma, and the outcome is often poorer distant metastases. In this study, we attempted to identify risk factors for FTC.Between 1989 1997, 134 FTC underwent initial surgery, their median follow-up period was 12.5 years. Seventeen had widely invasive FTC, 117 minimally FTC. were observed 36 (26.9%). Thirteen of these at time surgery (M1), other 23 diagnosed during periods. Risk...
Background: Radioiodine ablation after total thyroidectomy is the generally accepted treatment for patients with widely invasive follicular thyroid carcinoma (FTC). The therapeutic strategy minimally FTC, on other hand, still a matter of controversy. histological diagnosis FTC often made lobectomy. aim this study was to determine factors associated development distant metastases in FTC. Methods: Between 1989 and 2006, 251 underwent initial surgery at our hospital. Their median follow-up...
The objective was to evaluate the clinical behavior and outcome of 202 papillary thyroid cancers in Graves' disease patients during period 1994-2004.This a retrospective, non-randomized case-control study.Since 1994, we have included an ultrasonogram neck initial examination who consult our outpatient clinic. We evaluated tumor status long-term with cancer age- size-matched euthyroid as controls. Serum TSH receptor antibody (TRAb) measured group.A total 154 were diagnosed treated surgically....
Background: Methimazole (MMI) is usually used at an initial dose of 30 mg/day for severe Graves' disease (GD) hyperthyroidism, but adverse effects are more frequent this than MMI 15 mg/day. Objectives: We designed a regimen to address the lack primary therapeutic effect by combining it with inorganic iodine 38.2 Our aim was compare two regimens (MMI mg+inorganic (M15+I) vs. (M30)) in terms effect, effects, and remission rate. Design Patients: In prospective study, 310 patients untreated GD...
To control hyperthyroidism due to Graves' disease, antithyroid drugs should be administered. Several studies have shown that exposure methimazole (MMI) during the first trimester of pregnancy increases incidence specific congenital anomalies are collectively referred as MMI embryopathy. Congenital associated with propylthiouracil (PTU) also recently been reported.This study investigated whether substituting potassium iodide (KI) for in would result a lower major than continuing treatment...
Abstract Lenvatinib is a substrate of cytochrome P450 (CYP) 3A and ATP-binding cassette (ABC) transporters. In this study, we aimed to evaluate how CYP3A4/5 ABC transporter polymorphisms affected the mean steady-state dose-adjusted plasma trough concentrations (C 0 ) lenvatinib in cohort 40 Japanese patients with thyroid cancer. CYP3A4 20230G > A ( *1G ), CYP3A5 6986A G *3 ABCB1 1236C T, 2677G T/A, 3435C ABCC2 −24C ABCG2 421C genotypes were determined using polymerase chain...
Abstract Context The specific characteristics of pediatric and adolescent differentiated thyroid cancer (DTC) is the more frequent occurrence distant metastasis (DM) compared with adult DTC. Objective To investigate clinical outcomes DM in this population analyze risk factors related to DM. Design, Setting, Participants Medical records 171 patients DTC < 19 years old, who underwent initial surgery between 1979 2014 were retrospectively reviewed. Main Outcome Measure Clinical responses...
Background: In the recent American Thyroid Association (ATA) guidelines for adult differentiated thyroid carcinoma (DTC) patients, risk stratification is clearly defined and lobectomy acceptable low-risk DTC. However, children with DTC in ATA pediatric rather unclear, total thyroidectomy recommended all patients any risk. The aim of this study was to attempt based on our experience consider appropriate extent thyroidectomy, especially population. Patients Methods: subjects were 153 ≤18 years...
The management of papillary thyroid carcinoma (PTC), particularly in cases with clinically apparent lateral neck lymph node metastasis (cN1b), remains an area debate. surgical options for PTC, including total thyroidectomy and lobectomy, have distinct impacts on patients' outcomes quality life.