A5072783490- Thyroid Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Thyroid and Parathyroid Surgery
- Breast Lesions and Carcinomas
- BRCA gene mutations in cancer
- Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Neuroendocrine Tumor Research Advances
- Epigenetics and DNA Methylation
- Medical Imaging and Pathology Studies
- Cancer Cells and Metastasis
- Head and Neck Anomalies
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Reconstructive Surgery and Microvascular Techniques
- Parathyroid Disorders and Treatments
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Breast Implant and Reconstruction
- Genetic Syndromes and Imprinting
- Advanced Breast Cancer Therapies
- Cancer Immunotherapy and Biomarkers
- Hedgehog Signaling Pathway Studies
- Neutropenia and Cancer Infections
Yokohama City University
2015-2025
Kanagawa Cancer Center
2012-2022
Kanagawa Prefectural Hospital Organization
2008-2022
Saitama Cancer Center
2019
Tokyo Metropolitan Komagome Hospital
2019
Shikoku Cancer Center
2019
Chiba Cancer Center
2019
Yokohama City University Hospital
2008-2017
Ito Hospital
2012
Wake Forest University
2007
The prognostic value of the sixth edition AJCC/UICC TNM classification is currently unclear.The aim was to evaluate edition.We retrospectively assessed 354 primary differentiated thyroid carcinomas (77 men and 277 women; age, 51.2 yr; follow-up, 107.6 months) between 1964 2003. Sixty percent patients underwent lobectomy, 40% subtotal/total thyroidectomy, only 2% were given radioiodine. There 153, 104, 86, 11 in fifth stages I, II, III, IV, 175, 76, 14, 68, 10, IVA, IVB, IVC, respectively.New...
Anaplastic thyroid cancer (ATC) is a rare and extremely aggressive malignancy, with median survival of less than 6 months due to rapid progression resistance multimodal therapies. Effective treatment strategies have not been identified. A prospective clinical study was performed objectively evaluate outcomes paclitaxel.An investigator-initiated, multicenter, nonrandomized, open-label, single-arm the feasibility efficacy weekly paclitaxel (80 mg/m(2)) administration for patients...
Anaplastic thyroid cancer (ATC) is associated with an extremely poor prognosis and resistant to the majority of chemotherapies. In 2015, lenvatinib was approved for treating ATC in Japan. The present study aimed evaluate overall survival (OS) patients treated lenvatinib. A total 23 a definitive histological diagnosis who were at Kanagawa Cancer Center (Yokohama, Kanagawa. Japan) enrolled. Surgical treatment possible 10 (including one debulking surgery), postoperatively started. remaining 13...
The tumor-node-metastasis (TNM) classification system to categorized anaplastic thyroid cancer (ATC) was revised.The revised evaluated using a large database of ATC patients.A total 757 patients were analyzed. proportion and median overall survival values (OS: months) for each T category T1 (n = 8, 1.1%, 12.5), T2 43, 5.7%, 10.9), T3a 117, 15.5%, 5.7), T3b 438, 57.9%, 3.9), T4 151, 19.9%, 5.0). OS the N0 N1 5.9 4.3, respectively (log-rank p < 0.01). Sixty-three (58.3%) migrated from stage IV...
Abstract Background Mixed medullary and follicular cell-derived thyroid carcinoma (MMFCC) is characterized by the coexistence of C cell–derived tumour cell populations within same lesion. Due to its rarity, etiology clinical course remain unclear, treatment for advanced or recurrent cases has not been established. Case presentation We report a case MMFCC treated with selpercatinib. The patient was 69-year-old male presenting tumors in right lobe upper mediastinum. Fine-needle aspiration...
OBJECTIVE To investigate the differences in pattern of glucose transporter (GLUT) gene expression between normal and tumour tissues among histological subtypes renal cell carcinomas (RCCs), as malignant cells are characterized by increased uptake use. MATERIALS AND METHODS Enhanced probably depends on overexpression GLUT, usually GLUT1 and/or GLUT3, but there few comprehensive studies to evaluate relative level GLUT kidney tissues, especially recently identified genes. In all, 71 surgical...
Abstract Some patients with differentiated thyroid cancer (DTC) may require an initial low dose (LD) of lenvatinib. However, few studies have investigated the efficacy LD We compared and tolerability lenvatinib at to those standard 24 mg in DTC. In this cross-sectional study, records DTC treated were retrospectively reviewed. Patients divided into 2 groups based on lenvatinib: a full-dose (FD) group that received mg/d less than mg/d. Categorical variables Fisher exact test continuous Student...
Background Breast cancer is the most common form of in Japan; genetic background and hereditary breast ovarian (HBOC) are implicated. The key to HBOC diagnosis involves screening identify high-risk individuals. However, medicine still developing; thus, many patients who may potentially benefit from have not yet been identified. Objective This study’s objective develop a chatbot system that uses augmented intelligence for determine whether meet National Comprehensive Cancer Network (NCCN)...
Thyroid dysfunction is occasionally reported after the administration of nivolumab. We report on incidence and risk factors for nivolumab-induced thyroid in patients with non-small lung cancer.A total 82 who received nivolumab between January 2016 December at Kanagawa Cancer Center were included. Prior to treatment, 72 had normal function.Among function prior was 19.5%. There no significant differences whom occurred regarding sex, age, dose, or administration. However, number doses...
Enhancer of zeste homolog 2 (EZH2) is a member the polycomb group genes, which are key factors in regulation cell proliferation and differentiation. EZH2 overexpressed many malignancies. We analyzed protein expression levels different histological subtypes thyroid cancer to examine its utility as prognostic factor.We examined by immunohistochemistry tissue samples from 67 cases poorly differentiated (PDTC) 48 anaplastic carcinoma (ATC), adjacent normal (DTC). differences among various types...
Anaplastic thyroid cancer (ATC) is an orphan disease with extremely poor prognosis. In particular, unresectable stage IVC ATC difficult to treat and associated a survival of only few months, even when treated irradiation and/or chemotherapy. 2015, lenvatinib was approved for the treatment in Japan. The aim present study evaluate efficacy ATC. A total 32 patients pathologically confirmed who were at Kanagawa Cancer Center between 2011 2018 included study, whom 16 (L group). remaining received...
In patients with distant metastasis, treatment for differentiated thyroid cancer (DTC) includes complete total thyroidectomy, followed by radioactive iodine (RAI) therapy metastatic lesions. Tyrosine kinase inhibitor (TKI) is the final option lesions, which incurable surgery/RAI therapy. The present study examined whether outcomes DTC in metastasis improved following TKI treatment. This included 147 (median age, 71; range, 33‑91 years) who underwent surgery our hospitals and were diagnosed...
Herein, we report two extremely rare cases of differentiated thyroid carcinoma (DTC) with extended tumor thrombus or mediastinum lymph node metastasis (LNM) involving the superior vena cava (SVC), causing SVC syndrome. Both these patients were successfully treated radical resection and reconstruction using autologous tissue instead an expanded polytetrafluoroethylene (ePTFE) graft. The left brachiocephalic vein was used to reconstruct in a papillary patient LNM pericardial patch follicular...
In metastatic breast cancer, the status of estrogen receptor (ER), progesterone (PR), and human epidermal growth factor 2 (HER2), as well Ki-67 index sometimes change between primary lesions. However, in expression levels enhancer zeste homolog (EZH2) lesions has not been determined cancer. Ninety-six cancer patients had biopsies or resections September 1990 February 2014 at Kanagawa Cancer Center. We evaluated ER, PR, HER2, Ki-67, EZH2 their corresponding using immunohistochemistry....
Abstract Background Parathyroid carcinoma is a rare disease with frequency of 0.005% all malignancies [1, 2]. Various aspects its pathogenesis, diagnosis, and treatment remain poorly understood. Furthermore, cases secondary hyperparathyroidism are fewer. In this case report, we describe left parathyroid hyperparathyroidism. Case presentation The patient was 54-year-old woman who had been on hemodialysis since the age 40 years. At 53 years age, her calcium levels were high, she diagnosed...
As Asians are more vulnerable to febrile neutropenia (FN) than Caucasians, evaluations of FN incidence and risk factors in important for the appropriate use primary pegfilgrastim (PEG-G).Japanese breast cancer patients receiving standard adjuvant chemotherapies were prospectively enrolled multicenter institutions from August 2015 July 2017. was evaluated 2 treatment policies: true (T-FN): ≥37.5 °C, grade 4 neutropenia, mandatory hospital visit (visiting); surrogate (S-FN): oral antibiotic,...