A5014187053- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Thyroid Disorders and Treatments
- Mobile Health and mHealth Applications
- Bariatric Surgery and Outcomes
- Health Literacy and Information Accessibility
- Pregnancy and Medication Impact
- Breastfeeding Practices and Influences
- Thyroid Cancer Diagnosis and Treatment
- Immune Response and Inflammation
- Bone health and treatments
- Obesity, Physical Activity, Diet
- Growth Hormone and Insulin-like Growth Factors
- Asthma and respiratory diseases
- Reproductive System and Pregnancy
- Neuroscience of respiration and sleep
- Cardiovascular Issues in Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- DNA Repair Mechanisms
- Reproductive Health and Technologies
- Preterm Birth and Chorioamnionitis
- Ovarian function and disorders
- Antibiotics Pharmacokinetics and Efficacy
- Maternal and fetal healthcare
National Center For Child Health and Development
2016-2025
Adult Congenital Heart Association
2020
Kanazawa Medical University
2020
Shimane University
2020
Community Link
2020
Saiseikai Central Hospital
2020
Tokyo Medical and Dental University
2020
Mount Sinai Hospital
2016
University of Toronto
2016
Aalborg University Hospital
2016
Background Amlodipine is used for the treatment of hypertension, but reports on its use in early pregnancy are limited. Methods and Results In present study, we recruited 231 women with chronic including those who received amlodipine or other antihypertensives during pregnancy, investigated frequencies morphologic abnormalities their offspring. Specifically, evaluated 48 neonates exposed to first trimester (amlodipine group, Group A), 54 than (other antihypertensive O), 129 not...
Reports of hypothyroidism after hysterosalpingography (HSG) using lipiodol are emerging. The present study was designed to investigate the changes in serum iodine concentration (SIC), urinary concentration/creatinine excretion (UI/Cr), and thyroid function before HSG lipiodol.The prospective observation included 22 infertile euthyroid women with no previous history disease. All underwent between April 2007 August 2008 at our institution. We examined SIC, UI/Cr, HSG, 4, 8, 12, 24 weeks, 9-12...
OBJECTIVE: To evaluate the effects of age and season on menstrual cycle length basal body temperature (BBT). We also examined climate BBT, taking into account Japanese geographic social characteristics. METHODS: In this retrospective cohort study, we analyzed data from 6 million cycles entered a smartphone application 310,000 females 2016 to 2017. Only those who more than 10 in 2 years were included. Generalized estimation equations used adjust for confounding factors within-person...
DNA copy number changes are the most frequent genomic alterations in cancer cells. The ribosomal (rDNA) region is particularly vulnerable to such due its repetitive nature. Here, we demonstrate that Rad27/FEN-1, a structure-specific nuclease budding yeast, plays crucial role maintaining rDNA stability. production of extrachromosomal circles and severe chromosomal instability observed rad27∆ mutant, independently Fob1-mediated replication fork arrest double-strand break (DSB) formation rDNA....
Abstract To determine the optimal timing for influenza vaccination in pregnant women, we measured alterations types 1 and 2 T helper cell (Th1/Th2) balance during pregnancy, monitored specific immunity to inoculated antigens after with inactivated vaccine, evaluated relevance of Th1/Th2 ratio immune responses vaccination, maintenance high antibody titers until delivery transplacental transfer rate. No significant were noted 65% women among whom was lower than 9.9% first trimester. In those...
Basedow病や慢性甲状腺炎などの甲状腺疾患は妊娠可能年齢の女性に多くみられることから，甲状腺疾患の診療を行う上で妊娠中の管理にも精通しておく必要がある．Basedow病では，チアマゾールの催奇形性とPTUの重篤な副作用リスクの両者を考慮して良好な甲状腺機能のコントロールを目指す必要があり，時に甲状腺専門医，産科医および新生児科（小児科）医との連携が必要となる．慢性甲状腺炎ではレボサイロキシン量の細やかな調節が重要である．
ABSTRACT Objective To quantify the association between a combination of modifiable prepregnancy lifestyle factors and risk adverse pregnancy outcomes (APOs). Design Prospective cohort study. Setting The Japan Environment Children's Study. Population A total 79 703 pregnant Japanese women without chronic disease. Methods Maternal before was assessed using self‐administered questionnaire. healthy score (HLS, 0–5 points) calculated based on adherence to five factors: weight, high‐quality diet,...
ABSTRACT Aim To elucidate risk factors associated with adverse perinatal outcomes in early‐gestational diabetes mellitus (GDM). Materials and Methods A dataset of 385 early‐GDM cases from a prospective cohort was analyzed. Early‐GDM diagnosed if one or more the following criteria were met: fasting plasma glucose (PG) levels 92–125 mg/dL, 1‐h PG ≥180 2‐h ≥153 mg/dL during 75‐g oral tolerance test before 20 weeks gestation. Multivariate analysis used to examine associations between candidate...
ABSTRACT Aims/Introduction We evaluated a simple diagnostic gestational diabetes mellitus (GDM) strategy (Japanese COVID‐19 GDM strategy) published by the Japanese Society of Diabetes and Pregnancy using group data from Outcomes for Mother Baby (DREAMBee) study. Materials Methods The study included 803 mothers with diagnosed after 24 weeks an oral glucose tolerance test 1,356 normal (NGT) DREMBee They were reclassified strategies (COVID‐19 NGT) glycated hemoglobin (HbA1c) random plasma or...
Pregnant women with Graves' disease (GD) who have undergone thyroidectomy or radioactive iodine therapy can high levels of thyroid-stimulating hormone (TSH) receptor antibodies, which are transferred to the fetus via placenta, posing a risk for fetal GD. This retrospective observational study, conducted at two high-level perinatal medical centers in Tokyo and Osaka, Japan, aimed identify predictors GD pregnant had therapy. In total, 65 were included, 79 singleton pregnancies fetuses...
Gestational diabetes (GDM) and type 2 (T2DM) share part of pathomechanism several T2DM susceptibility genes are demonstrated to be associated with GDM. No information on the genetics GDM, however, was available in Japanese women. In this study, risk variants (45 single nucleotide polymorphisms [SNPs] from 36 genes) identified previous studies were genotyped using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry a cohort 171 women GDM 128 normal glucose tolerance...
In Japan, the increasing frequency of underweight among women reproductive age and accompanying increase in rate low birth weight (LBW) are social issues. The study aimed to establish a prospective registry system for gestational diabetes mellitus (GDM) Japan clarify actual status GDM according International Association Diabetes Pregnancy Study Groups (IADPSG) criteria.Pregnant with those normal glucose tolerance (NGT) group were enrolled Outcome Mother Baby from October 2015. Pregnant...