A5071575645- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Chronic Kidney Disease and Diabetes
- Diabetes Treatment and Management
- Blood Pressure and Hypertension Studies
- Dialysis and Renal Disease Management
- Sodium Intake and Health
- Adipokines, Inflammation, and Metabolic Diseases
- COVID-19 Clinical Research Studies
- Nephrotoxicity and Medicinal Plants
- Adipose Tissue and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Renal Diseases and Glomerulopathies
- Acute Kidney Injury Research
- Apelin-related biomedical research
- Receptor Mechanisms and Signaling
- Pharmacology and Obesity Treatment
- Diabetes Management and Research
- Heart Failure Treatment and Management
- Lipoproteins and Cardiovascular Health
- Metabolism, Diabetes, and Cancer
- Potassium and Related Disorders
- Ion Transport and Channel Regulation
- Digital Mental Health Interventions
- Gout, Hyperuricemia, Uric Acid
Yokohama City University
2016-2025
Abstract Tumor necrosis factor (TNF)-α is a potent mediator of inflammation and involved in the pathophysiology chronic kidney disease (CKD). However, effects TNF-α inhibition on progression fibrosis have not been fully elucidated. We examined by etanercept (ETN) mice with aristolochic acid (AA) nephropathy as model fibrosis. C57BL/6 J were administered AA for 4 weeks, followed 4-week remodeling period. The exhibited fibrosis, functional decline, albuminuria concomitant increases renal mRNA...
To compare the therapeutic effects of glucose-dependent insulinotropic polypeptide (GIP)/ glucagon-like peptide-1 receptor agonists (GLP-1RAs) or GLP-1RAs in Japanese patients with type 2 diabetes (T2D).We systematically searched PubMed, MEDLINE, EMBASE, and Cochrane Library up to July 2023. Randomized controlled trials (RCTs) that compared GIP/GLP-1RAs T2D were selected. A network meta-analysis was conducted indirectly treatments, focusing on efficacy reducing glycated haemoglobin (HbA1c)...
Ischemia reperfusion injury (IRI) is a major cause of acute kidney (AKI) and ultimately leads to renal fibrosis, primarily via the transforming growth factor-β (TGF-β) pathway. Leucine-rich alpha-2-glycoprotein 1 (LRG1), novel modulator TGF-β pathway, has been implicated in modulation fibrosis by affecting TGF-β/Smad3 signaling axis. However, role LRG1 transition from AKI chronic disease (CKD) remains unclear. This study aimed investigate functional during remodeling phase post-IRI....
Abstract Background We investigated the effects of sacubitril/valsartan, a first-in-class angiotensin receptor neprilysin inhibitor (ARNI), on 24-hour blood pressure (BP) and safety for 12 weeks in Japanese patients with non-dialysis advanced chronic kidney disease (CKD). Methods conducted prospective, single-arm exploratory study. Patients CKD stage G4-5 (estimated glomerular filtration (eGFR) <30 mL/min/1.73 m2) who did not achieve their BP goals blocker (ARB) administration, were...
The renin-angiotensin system has a pivotal role in the pathophysiology of visceral obesity. Angiotensin II type 1 receptor (AT1R) is major player signal transduction system, and overactivation this signaling contributes to progression We have shown that AT1R-associated protein (ATRAP) promotes AT1R internalization from cell surface into cytoplasm along with suppression tissue signaling. In study, we examined whether enhancement adipose ATRAP expression could efficiently prevent diet-induced...
Abstract Background The Y-AIDA study was designed to investigate the renal- and home blood pressure (BP)-modulating effects of add-on dapagliflozin treatment in Japanese individuals with type 2 diabetes mellitus (T2DM) albuminuria. Methods We conducted a prospective, multicenter, single-arm study. Eighty-six patients T2DM, HbA1c 7.0–10.0%, estimated glomerular filtration rate (eGFR) ≥ 45 mL/min/1.73 m , urine albumin-to-creatinine ratio (UACR) 30 mg/g creatinine (gCr) were enrolled, 85 these...
Background Increasing physical activity improves glycemic control in patients with type 2 diabetes (T2D). Mobile health (mHealth) interventions have been proven to increase exercise, but engagement often fades time. As the use of behavior theory mHealth design can effectiveness, we developed StepAdd, an intervention based on constructs social cognitive (SCT). StepAdd exercise self-efficacy and self-regulation through goal-setting, barrier-identifying, barrier-coping strategies, as well...
The kidney is easily affected by aging-associated changes, including glomerulosclerosis, tubular atrophy, and interstitial fibrosis. Particularly, renal tubulointerstitial fibrosis a final common pathway in most forms of progressive disease. Angiotensin II type 1 receptor (AT1R)-associated protein (ATRAP), which was originally identified as molecule that binds to AT1R, highly expressed the kidney. Previously, we have shown ATRAP suppresses hyperactivation AT1R signaling, but does not affect...
The kidney is one of the most susceptible organs to age-related impairments. Generally, renal aging accompanied by fibrosis, which final common pathway chronic diseases. Aristolochic acid (AA), a nephrotoxic agent, causes AA nephropathy (AAN), characterized progressive fibrosis and functional decline. Although associated with aging, whether induces remains unclear. aim present study investigate potential use AAN as model aging. Here, we examined senescence-related factors in models...
Abnormal angiogenesis plays a major role in the development of early stage diabetic nephropathy. Vascular endothelial growth factor (VEGF) is classical proangiogenic that regulates abnormal glomerular linked to hypertrophy Leucine-rich α -2-glycoprotein-1 (LRG1) was recently reported as novel expressed cells and promotes by modulating transforming factor- β signaling pathway. However, pathophysiology LRG1 nephropathy remains largely unknown. In present study, we investigated intrarenal...
Outcomes in acute decompensated heart failure (ADHF) have remained poor. Worsening renal function (WRF) is common among patients with ADHF. However, the impact of WRF on prognosis controversial. We hypothesized that ADHF, achievement concomitant decongestion would diminish signal for harm associated WRF.We performed a systematic search PubMed, EMBASE, and Cochrane Library up to December 2019 studies assessed signs during ADHF admission. The primary outcome was all-cause mortality...
Considering the prevalence of obesity and global aging, consumption a high-protein diet (HPD) may be advantageous. However, an HPD aggravates kidney dysfunction in patients with chronic disease (CKD). Moreover, effects on function healthy individuals are controversial. In this study, we employed remnant mouse model as CKD aimed to evaluate injury under conditions non-CKD CKD. Mice were divided into four groups: sham surgery (sham) + normal (ND) group, 5/6 nephrectomy (Nx) ND group Nx group....
A third dose of SARS-CoV-2 mRNA vaccine has been administered in several countries.1,2 Patients with end-stage kidney disease have a weak immune response to 2-sessional doses the vaccine.3–7 Because patients undergoing hemodialysis (HD) are at high risk for COVID-19 severity and death, they prioritized vaccination programs worldwide.8,9
Aim: Peripheral artery disease (PAD) severely impairs patient prognosis and quality of life (QOL). Although lipoprotein apheresis (LA) has been applied to patients with PAD elevated serum atherogenic lipoproteins, we hypothesized that LA can be effective for treating even in controlled lipoproteins through pleiotropic anti-atherosclerotic effects beyond removal. This study aimed evaluate the efficacy treatment-resistant focusing on QOL.
Abstract Enhancement of AT1 receptor-associated protein (ATRAP) in adipose tissue improves high fat diet (HFD)-induced visceral obesity and insulin resistance, suppresses oxidative stress. However, HFD loading is not a direct stimulatory factor for receptor. In the present study, we investigated effect chronic, low-dose angiotensin II (Ang II) stimulation on glucose lipid metabolism mice functional role ATRAP. ATRAP expression was higher (5–10-fold) skeletal muscle (approximately 1.6-fold)...