A5081793444- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Blood Pressure and Hypertension Studies
- Receptor Mechanisms and Signaling
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Pharmacological Effects of Natural Compounds
- Sodium Intake and Health
- Chronic Kidney Disease and Diabetes
- Pharmacology and Obesity Treatment
- Regulation of Appetite and Obesity
- Traditional Chinese Medicine Studies
- Heart Rate Variability and Autonomic Control
- Ion Transport and Channel Regulation
- Cardiovascular Health and Disease Prevention
- Plant-based Medicinal Research
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Apelin-related biomedical research
- Nephrotoxicity and Medicinal Plants
- Phytochemistry and biological activity of medicinal plants
- Lipoproteins and Cardiovascular Health
- Diabetes Management and Research
- Diet and metabolism studies
Fukushima Medical University
2021-2025
Yokohama City University
2015-2024
Kumamoto University
2013
Tokyo Medical and Dental University
2013
Tulane University
2013
Abstract Aim We aimed to elucidate the present clinical situation, future challenges, and potential need for diagnostic support software in Kampo medicine. Methods conducted an online survey (comprising 28 questions) of Japanese physicians from 23 24 January 2024 via MedPeer . The participants' responses were stratified according their age distribution. Results evaluated data 652 respondents. most common respondent groups those 30s 40s. specialty respondents was internal medicine (43.7%)....
Drug-induced pseudoaldosteronism is a typical adverse effect of Kampo formulas. Previous research described the potential risks formula-linked pseudoaldosteronism. However, few studies assessed risk factors using real-world database and data-mining approach. Using Japanese Adverse Drug Event Report database, we extracted reports for 148 formulas covered by national health insurance. events were decided according to preferred terminology Medical Dictionary Regulatory Activities/Japanese...
Activation of tissue angiotensin II (Ang II) type 1 receptor (AT1R) plays an important role in the development vascular remodelling. We have shown that AT1R-associated protein (ATRAP/Agtrap), a specific binding AT1R, functions as endogenous inhibitor to prevent pathological activation renin-angiotensin system. In this study, we investigated effects ATRAP on Ang II-induced remodelling.Transgenic (Tg) mice with pattern aortic vascular-dominant overexpression were obtained, and or vehicle was...
Angiotensin II type 1 receptor (AT1R)–associated protein (ATRAP) promotes AT1R internalization along with suppression of pathological activation tissue signaling. However, the functional significance ATRAP in renal sodium handling and blood pressure regulation under stimuli is not fully resolved. Here we show mice a gene-targeted disruption was comparable to that wild-type at baseline. ATRAP-knockout mice, angiotensin II–induced hypertension exacerbated extent positive balance increased by...
Abstract Aim This study aims to assess the motivation, capability, and working environment of Japanese traditional (Kampo) medicine (JTM) specialists certified physicians affiliated with Japan Society for Oriental Medicine regarding clinical research. Their awareness perception COVID‐19 studies their interest in research based on JTM diagnostic concepts are explored. Methods An online survey was conducted between May 20 June 30, 2024, using Google Forms, targeting 2146 Medicine‐certified...
Abstract Aim We conducted a web‐based survey of physician members the Japan Society for Oriental Medicine (JSOM) to investigate trends in Kampo formulas prescribed by specialists. Methods JSOM were surveyed using Microsoft Forms from December 1, 2022 January 27, 2023. Respondents subjectively ranked their top five formulas, commenting on each formula. Results There 475 respondents, representing 6.4% all members. The respondents had similar sex and age distributions affiliation regions most...
We have previously shown that angiotensin II type 1 receptor-associated protein (ATRAP/ Agtrap ) interacts with the receptor and promotes constitutive internalization of so as to inhibit pathological activation its downstream signaling but preserve baseline physiological activity. The present study was designed investigate role renal ATRAP in II–dependent hypertension. generated transgenic mice dominantly expressing tubules, including distal tubules. exhibited no significant change blood...
Background Metabolic disorders with visceral obesity have become a major medical problem associated the development of hypertension, type 2 diabetes, and dyslipidemia and, ultimately, life‐threatening cardiovascular renal diseases. Adipose tissue dysfunction has been proposed as cause obesity‐related metabolic disorders, moving toward proinflammatory phenotype. Methods Results Here we first report that adipose tissues from patients mice exhibit decreased expression ATRAP / Agtrap , which is...
The renin-angiotensin system has a pivotal role in the pathophysiology of visceral obesity. Angiotensin II type 1 receptor (AT1R) is major player signal transduction system, and overactivation this signaling contributes to progression We have shown that AT1R-associated protein (ATRAP) promotes AT1R internalization from cell surface into cytoplasm along with suppression tissue signaling. In study, we examined whether enhancement adipose ATRAP expression could efficiently prevent diet-induced...
The kidney is one of the most susceptible organs to age-related impairments. Generally, renal aging accompanied by fibrosis, which final common pathway chronic diseases. Aristolochic acid (AA), a nephrotoxic agent, causes AA nephropathy (AAN), characterized progressive fibrosis and functional decline. Although associated with aging, whether induces remains unclear. aim present study investigate potential use AAN as model aging. Here, we examined senescence-related factors in models...
To compare the therapeutic effects of glucose-dependent insulinotropic polypeptide (GIP)/ glucagon-like peptide-1 receptor agonists (GLP-1RAs) or GLP-1RAs in Japanese patients with type 2 diabetes (T2D).We systematically searched PubMed, MEDLINE, EMBASE, and Cochrane Library up to July 2023. Randomized controlled trials (RCTs) that compared GIP/GLP-1RAs T2D were selected. A network meta-analysis was conducted indirectly treatments, focusing on efficacy reducing glycated haemoglobin (HbA1c)...
The kidney is easily affected by aging-associated changes, including glomerulosclerosis, tubular atrophy, and interstitial fibrosis. Particularly, renal tubulointerstitial fibrosis a final common pathway in most forms of progressive disease. Angiotensin II type 1 receptor (AT1R)-associated protein (ATRAP), which was originally identified as molecule that binds to AT1R, highly expressed the kidney. Previously, we have shown ATRAP suppresses hyperactivation AT1R signaling, but does not affect...
Accumulating evidence indicates that metabolic dysfunction with visceral obesity is a major medical problem associated the development of hypertension, type 2 diabetes (T2DM) and dyslipidemia, ultimately severe cardiovascular renal disease. Therefore, an effective anti-obesity treatment concomitant improvement in profile important for obesity. Bofu-tsu-shosan (BOF) one oriental herbal medicine clinically available to treat Japan. Although BOF candidate as novel therapeutic strategy improve...
Abnormal angiogenesis plays a major role in the development of early stage diabetic nephropathy. Vascular endothelial growth factor (VEGF) is classical proangiogenic that regulates abnormal glomerular linked to hypertrophy Leucine-rich α -2-glycoprotein-1 (LRG1) was recently reported as novel expressed cells and promotes by modulating transforming factor- β signaling pathway. However, pathophysiology LRG1 nephropathy remains largely unknown. In present study, we investigated intrarenal...