A5035018795- Circadian rhythm and melatonin
- Genetic Neurodegenerative Diseases
- Photoreceptor and optogenetics research
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- Child Development and Digital Technology
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Autism Spectrum Disorder Research
- Mast cells and histamine
- Neuropeptides and Animal Physiology
- Retinal Development and Disorders
- Hepatitis C virus research
- Receptor Mechanisms and Signaling
- Hypothalamic control of reproductive hormones
- Psychological and Temporal Perspectives Research
- Regulation of Appetite and Obesity
- Hepatitis B Virus Studies
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
University of California, Los Angeles
2014-2025
Neurobehavioral Systems
2016-2025
Chinese PLA General Hospital
2017-2024
RELX Group (United States)
2020
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by the abnormal expansion of CGG repeats in fragile mental retardation 1 (FMR1) gene. Many FXS patients experience sleep disruptions, and we sought to explore these symptoms along with possible benefits scheduled feeding intervention using Fmr1 knockout (KO) mouse model. These mutants displayed clear evidence for circadian disturbances including delay onset fragmented activity rhythms increases cycle-to-cycle variability....
In Huntington's disease (HD), the uninterrupted CAG repeat length, but not polyglutamine predicts onset. However, underlying pathobiology remains unclear. Here, we developed bacterial artificial chromosome (BAC) transgenic mice expressing human mutant huntingtin (mHTT) with uninterrupted, and somatically unstable, repeats that exhibit progressive disease-related phenotypes. Unlike prior mHTT models stable, CAA-interrupted, polyglutamine-encoding repeats, BAC-CAG show robust...
Huntington’s disease (HD) patients suffer from a progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction. Disturbances sleep/wake cycles are common among HD with reports of delayed sleep onset, frequent bedtime awakenings, fatigue during the day. The heterozygous Q175 mouse model has been shown to phenocopy many core symptoms including circadian dysfunctions. Because dysfunction manifests early both models, we sought determine if...
The female reproductive cycle is gated by the circadian timing system and may be vulnerable to disruptions in system. Prior work suggests that vasoactive intestinal peptide (VIP)-expressing neurons suprachiasmatic nucleus (SCN) are one pathway which clock can influence estrous cycle, but impact of loss this on reproduction has not been assessed. In present study, we first examine genetic neuropeptide VIP success mice. Significantly, mutant females produce about half offspring their wild-type...
Huntington's disease (HD) patients suffer from progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction. Disturbances sleep-wake cycles are common among HD with reports of delayed sleep onset, frequent bedtime awakenings, excessive fatigue. The BACHD mouse model exhibits many core symptoms including circadian Because dysfunction manifests early the both models, we sought to determine if interventions improve rhythmicity could benefit delay...
Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by the abnormal expansion of CGG repeats in fragile mental retardation 1 (FMR1) gene. Many FXS patients experience sleep disruptions, and we sought to explore these symptoms along with possible benefits scheduled feeding intervention using Fmr1 knockout (KO) mouse model. These mutants displayed clear evidence for circadian disturbances including delay onset fragmented activity rhythms increases cycle-to-cycle variability....
Patients with Huntington's disease (HD) exhibit movement disorders, psychiatric disturbance and cognitive impairments as the progresses. Abnormal sleep/wake cycles are common among HD patients reports of delayed sleep onset, fatigue during day, a pattern melatonin secretion all which suggest circadian dysfunction. Mouse models confirm disrupted rhythms pathophysiology found in central clock (suprachiasmatic nucleus). Importantly, dysfunction manifests early disease, even before classic motor...
While Huntington's disease (HD) is classified as a neurological disorder, HD patients exhibit high incidence of cardiovascular events leading to heart failure and death. In this study, we sought better understand the phenotype using BACHD mouse model. The age-related decline in function was assessed by echocardiograms, electrocardiograms, histological microarray analysis. We found that structural functional differences between WT hearts start at 3 months age continue throughout life. aged...
Nighttime light pollution is linked to metabolic and cognitive dysfunction. Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycle, may be particularly vulnerable the impact of circadian disruptors. In this study, we examined exposure dim at night (DLaN, 5 lx) a model ASD: contactin associated protein-like 2 knock out (Cntnap2 KO) mice. DLaN was sufficient disrupt locomotor activity rhythms, exacerbate excessive grooming diminish social preference...
Abstract Huntington's disease ( HD ) is an autosomal dominant, neurodegenerative disorder characterized by motor as well nonmotor symptoms for which there currently no cure. The Q175 mouse model of recapitulates many the identified in patients including disruptions sleep/wake cycle. In this study, we sought to determine if daily administration histamine‐3 receptor (H3R) antagonist/inverse agonist 6‐[(3‐cyclobutyl‐2,3,4,5‐tetrahydro‐1H‐3‐benzazepin‐7‐yl)oxy]‐N‐methyl‐3‐pyridinecarboxamide...
Mice lacking a functional Biogenesis of Lysosome-related Organelles Complex 1 (BLOC-1), such as those the pallid line, display cognitive and behavioural impairments reminiscent presented by individuals with intellectual developmental disabilities. Although disturbances in sleep/wake cycle are commonly lamented these individuals, underlying mechanisms, including possible role circadian timing system, still unknown. In this paper, we have explored sleep/circadian malfunctions mechanisms...
Balance between metabolic and reproductive processes is important for survival, particularly in mammals that gestate their young. How the nervous system coordinates this balance an active area of study. Herein, we demonstrate somatostatin (SST) neurons tuberal hypothalamus alter feeding a manner sensitive to states mice. Whereas chemogenetic activation SST increased food intake across sexes, ablation decreased only female mice during proestrus. This effect was apparent animals with low body...
Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycles, and they may be particularly vulnerable to the impact of circadian disruptors. We have previously shown that a 2-weeks exposure dim light at night (DLaN) disrupts diurnal rhythms, increases repetitive behaviors reduces social interactions contactin-associated protein-like 2 knock out (Cntnap2 KO) mice. The deleterious effects DLaN mediated by intrinsically photosensitive retinal ganglion cells...
To observe the recurrence condition of hepatitis B in different risk groups after liver transplantation an attempt to provide useful information on whether discontinue immunoglobulin (HBIG) future at early stage.
Abstract Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by the abnormal expansion of CGG repeats in fragile mental retardation 1 (FMR1) gene. Many FXS patients experience sleep disruptions, and we sought to explore these symptoms along with possible benefits scheduled feeding intervention using Fmr1 knockout (KO) mouse model. These mutants displayed clear evidence for circadian disturbances including delay onset fragmented activity rhythms increases cycle-to-cycle...
Abstract Many patients with autism spectrum disorders (ASD) show disturbances in their sleep/wake cycles, and may be particularly vulnerable to the impact of circadian disruptors. We have previously shown that exposure dim light at night (DLaN) contactin associated protein-like 2 knock out ( Cntnap2 KO) mice disrupts diurnal rhythms, increases repetitive behaviors while reducing social interactions. These negative effects DLaN mediated by intrinsically photosensitive retinal ganglion cells...